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| | SSIL_1585 | Cell division protein FtsI/penicillin-binding protein 2. (736 aa) |
| | udk | Uridine kinase. (211 aa) |
| | mltG | Predicted periplasmic solute-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (372 aa) |
| | SSIL_1495 | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (731 aa) |
| | apt | Adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | tgt | Queuine/archaeosine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribo [...] (385 aa) |
| | queA | S-adenosylmethionine:tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (345 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | SSIL_1196 | Hypothetical protein. (388 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | accD | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | murC | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (432 aa) |
| | SSIL_0888 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (144 aa) |
| | amj | Hypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (262 aa) |
| | SSIL_0668 | Uncharacterized Fe-S protein. (377 aa) |
| | SSIL_0508 | Nucleoside-diphosphate-sugar epimerase. (338 aa) |
| | SSIL_0500 | Histone acetyltransferase HPA2. (290 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (416 aa) |
| | purH | AICAR transformylase/IMP cyclohydrolase PurH. (511 aa) |
| | purN | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (351 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is th [...] (743 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ an [...] (227 aa) |
| | yexA | Phosphoribosylformylglycinamidine synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (81 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa) |
| | SSIL_0476 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (374 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa) |
| | guaA | GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (544 aa) |
| | murF | UDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa) |
| | ddl | D-alanine-D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (357 aa) |
| | glmU | N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa) |
| | SSIL_0064 | FAD synthase. (270 aa) |
| | SSIL_0096 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (445 aa) |
| | guaB | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | dacA | Uncharacterized conserved protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (278 aa) |
| | glmS | Glucosamine 6-phosphate synthetase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (599 aa) |
| | murB | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (303 aa) |
| | coaX | Putative transcriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa) |
| | SSIL_0015 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | SSIL_3777 | Predicted phosphohydrolase. (272 aa) |
| | SSIL_3733 | D-alanyl-D-alanine carboxypeptidase. (464 aa) |
| | SSIL_3716 | Gentisate 1,2-dioxygenase. (374 aa) |
| | SSIL_3687 | FAD synthase. (261 aa) |
| | xpt | Adenine/guanine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | SSIL_3614 | Hypothetical protein. (562 aa) |
| | SSIL_3582 | Predicted phosphohydrolase. (356 aa) |
| | uppP-2 | Uncharacterized bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | uppP | Uncharacterized bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (271 aa) |
| | SSIL_3441 | Uncharacterized protein, LmbE homologs. (225 aa) |
| | SSIL_3440 | Hypothetical protein. (117 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | murA-2 | UDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (425 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | SSIL_3379 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (386 aa) |
| | atpB | F0F1-type ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (241 aa) |
| | atpE | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpF | F0F1-type ATP synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa) |
| | atpH | F0F1-type ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa) |
| | atpA | F0F1-type ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpG | F0F1-type ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (285 aa) |
| | atpD | F0F1-type ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (471 aa) |
| | atpC | F0F1-type ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa) |
| | murA | UDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (433 aa) |
| | fabZ | 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa) |
| | tagA | Teichoic acid biosynthesis protein; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. (240 aa) |
| | SSIL_3311 | Lipid A core. (496 aa) |
| | SSIL_3306 | Uncharacterized membrane protein, putative virulence factor. (505 aa) |
| | SSIL_3279 | Uncharacterized protein. (565 aa) |
| | SSIL_3275 | UDP-N-acetylglucosamine 2-epimerase. (376 aa) |
| | SSIL_3226 | Uncharacterized protein. (225 aa) |
| | SSIL_3214 | Histone acetyltransferase HPA2. (142 aa) |
| | murE-2 | UDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (489 aa) |
| | murE | UDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (493 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | SSIL_3102 | Cell division protein FtsI/penicillin-binding protein 2. (726 aa) |
| | SSIL_3101 | Cell division protein FtsI/penicillin-binding protein 2. (638 aa) |
| | mraY | UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa) |
| | murD | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (450 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (305 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa) |
| | carA | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (366 aa) |
| | carB | Carbamoylphosphate synthase large subunit; Belongs to the CarB family. (1065 aa) |
| | pyrK | 2-polyprenylphenol hydroxylase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (257 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (303 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase. (187 aa) |
| | SSIL_3019 | Predicted RNA-binding protein; Belongs to the UPF0109 family. (77 aa) |
| | fliI | Flagellar biosynthesis/type III secretory pathway ATPase. (441 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | ribC | FAD synthase; Belongs to the ribF family. (316 aa) |
| | SSIL_2843 | D-alanyl-D-alanine carboxypeptidase. (472 aa) |
| | SSIL_2830 | Hypothetical protein. (224 aa) |
| | SSIL_2813 | Uncharacterized conserved protein. (165 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa) |
| | SSIL_2777 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (324 aa) |
| | SSIL_2739 | Predicted phosphohydrolase. (252 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (337 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | SSIL_2662 | Cell division protein FtsI/penicillin-binding protein 2. (639 aa) |
| | SSIL_2643 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase. (228 aa) |
| | SSIL_2634 | Phosphoglycerol transferase; Belongs to the LTA synthase family. (633 aa) |
| | SSIL_2624 | Ribonucleotide reductase, beta subunit. (294 aa) |
| | SSIL_2612 | Pantothenate kinase, acetyl-CoA regulated. (278 aa) |
| | SSIL_2604 | Phosphopantothenoylcysteine synthetase/decarboxylase. (220 aa) |
| | SSIL_2603 | Hypothetical protein. (268 aa) |
| | SSIL_2470 | Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa) |
| | dut | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa) |
| | SSIL_2345 | Hypothetical protein. (189 aa) |
| | SSIL_2185 | Uncharacterized protein. (111 aa) |
| | SSIL_2162 | Uridine kinase. (204 aa) |
| | murG | UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (358 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (325 aa) |
| | SSIL_1924 | Adenylate kinase. (170 aa) |
| | SSIL_1822 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (148 aa) |
| | SSIL_1745 | Uncharacterized conserved protein. (179 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (632 aa) |
| | SSIL_1684 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa) |
| | yqgS | Phosphoglycerol transferase. (633 aa) |
| | SSIL_1619 | Hypothetical protein. (162 aa) |
