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SSIL_3354 SSIL_3354 SSIL_3346 SSIL_3346 SSIL_3327 SSIL_3327 SSIL_3277 SSIL_3277 SSIL_3276 SSIL_3276 hpf hpf SSIL_3190 SSIL_3190 SSIL_0813 SSIL_0813 SSIL_0002 SSIL_0002 SSIL_0019 SSIL_0019 rplY rplY rnmV rnmV recR recR SSIL_0061 SSIL_0061 gyrB gyrB recF recF rpmH rpmH SSIL_0114 SSIL_0114 rpsF rpsF SSIL_0131 SSIL_0131 rpmG rpmG rplK rplK SSIL_0200 SSIL_0200 rplJ rplJ rplL rplL rpsG rpsG SSIL_0215 SSIL_0215 rpsJ rpsJ rplC rplC rplW rplW rplB rplB rpsC rpsC rpmC rpmC rpsQ rpsQ rplN rplN rplE rplE rpsN rpsN rpsH rpsH rplR rplR rpsE rpsE rpmD rpmD rplO rplO rpsK rpsK rplQ rplQ rplM rplM rpsI rpsI SSIL_0285 SSIL_0285 SSIL_0310 SSIL_0310 SSIL_0351 SSIL_0351 cshA cshA SSIL_0568 SSIL_0568 yfmL yfmL SSIL_0721 SSIL_0721 SSIL_0743 SSIL_0743 SSIL_0769 SSIL_0769 SSIL_0812 SSIL_0812 rpmF rpmF SSIL_3085 SSIL_3085 priA priA rpmB rpmB smc smc rpsP rpsP topA topA rpsB rpsB ylxQ ylxQ rpsO rpsO SSIL_2899 SSIL_2899 rpsU rpsU recO recO dnaG dnaG cshB cshB SSIL_2837 SSIL_2837 SSIL_2824 SSIL_2824 SSIL_2807 SSIL_2807 SSIL_2741 SSIL_2741 SSIL_2739 SSIL_2739 SSIL_2731 SSIL_2731 SSIL_2725 SSIL_2725 SSIL_0815 SSIL_0815 SSIL_0916 SSIL_0916 SSIL_1038 SSIL_1038 SSIL_1085 SSIL_1085 SSIL_1093 SSIL_1093 SSIL_1108 SSIL_1108 ezrA ezrA SSIL_1176 SSIL_1176 SSIL_1203 SSIL_1203 SSIL_1204 SSIL_1204 rpmI rpmI deaD deaD SSIL_1344 SSIL_1344 SSIL_1387 SSIL_1387 SSIL_2712 SSIL_2712 SSIL_2685 SSIL_2685 nth nth SSIL_2586 SSIL_2586 SSIL_2569 SSIL_2569 SSIL_2565 SSIL_2565 SSIL_2463 SSIL_2463 SSIL_2414 SSIL_2414 SSIL_2406 SSIL_2406 SSIL_2349 SSIL_2349 SSIL_2348 SSIL_2348 SSIL_2225 SSIL_2225 parE parE SSIL_2162 SSIL_2162 SSIL_2149 SSIL_2149 SSIL_2118 SSIL_2118 SSIL_1878 SSIL_1878 pdxS pdxS SSIL_1726 SSIL_1726 SSIL_1724 SSIL_1724 recN recN kynU kynU rpmG-2 rpmG-2 SSIL_1604 SSIL_1604 rpsT rpsT SSIL_1528 SSIL_1528 udk udk dtd dtd rpmA rpmA rplU rplU radC radC SSIL_1403 SSIL_1403 SSIL_3777 SSIL_3777 SSIL_3760 SSIL_3760 SSIL_3759 SSIL_3759 SSIL_3667 SSIL_3667 SSIL_3666 SSIL_3666 SSIL_3582 SSIL_3582 SSIL_3580 SSIL_3580 SSIL_3519 SSIL_3519 topB topB SSIL_3463 SSIL_3463 SSIL_3426 SSIL_3426 SSIL_3409 SSIL_3409 rpmE rpmE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SSIL_3354Superfamily II DNA/RNA helicase, SNF2 family. (925 aa)
SSIL_3346DNA repair protein. (154 aa)
SSIL_3327NADH dehydrogenase, FAD-containing subunit. (476 aa)
SSIL_3277Sialic acid synthase. (163 aa)
SSIL_3276Sialic acid synthase. (152 aa)
hpfRibosome-associated protein Y; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (185 aa)
SSIL_3190Uncharacterized conserved protein. (140 aa)
SSIL_0813Hypothetical protein. (242 aa)
SSIL_0002tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (336 aa)
SSIL_0019Predicted RNA binding protein. (142 aa)
rplYRibosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (217 aa)
rnmVSmall primase-like protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (213 aa)
recRRecombinational DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
SSIL_0061Uncharacterized protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (104 aa)
gyrBType IIA topoisomerase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (641 aa)
recFRecombinational DNA repair ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (372 aa)
rpmHRibosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
SSIL_0114Predicted transcriptional regulator; Belongs to the ParB family. (281 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
SSIL_0131Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
rpmGRibosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (62 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
SSIL_0200Ribosomal protein L1; Belongs to the universal ribosomal protein uL1 family. (113 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (119 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
SSIL_0215Signal transduction histidine kinase. (323 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (94 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (218 aa)
rpmCRibosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (66 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (166 aa)
rpmDRibosomal protein L30/L7E. (59 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa)
rplQRibosomal protein L17. (125 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa)
rpsIRibosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
SSIL_0285Small primase-like protein. (114 aa)
SSIL_0310Hypothetical protein. (376 aa)
SSIL_03515,10-methylenetetrahydrofolate reductase. (222 aa)
cshASuperfamily II DNA and RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (517 aa)
SSIL_0568tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (322 aa)
yfmLSuperfamily II DNA and RNA helicase. (410 aa)
SSIL_0721Signal transduction histidine kinase. (327 aa)
SSIL_0743FOG: TPR repeat. (508 aa)
SSIL_0769Beta-propeller domains of methanol dehydrogenase type. (256 aa)
SSIL_0812Replicative DNA helicase. (423 aa)
rpmFRibosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
SSIL_3085Uncharacterized conserved protein. (262 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (802 aa)
rpmBRibosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
smcChromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1193 aa)
rpsPRibosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa)
topATopoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] (694 aa)
rpsBRibosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (240 aa)
ylxQRibosomal protein HS6-type. (102 aa)
rpsORibosomal protein S15P/S13E; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
SSIL_2899Phytoene dehydrogenase. (524 aa)
rpsURibosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (57 aa)
recORecombinational DNA repair protein; Involved in DNA repair and RecF pathway recombination. (257 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (609 aa)
cshBSuperfamily II DNA and RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (436 aa)
SSIL_2837Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. (185 aa)
SSIL_2824FOG: TPR repeat. (233 aa)
SSIL_2807Uncharacterized conserved protein. (192 aa)
SSIL_2741Superfamily II DNA helicase. (481 aa)
SSIL_2739Predicted phosphohydrolase. (252 aa)
SSIL_2731Ribosomal protein S1. (380 aa)
SSIL_2725Bacterial nucleoid DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
SSIL_0815Superfamily II DNA helicase. (1097 aa)
SSIL_0916Hypothetical protein. (290 aa)
SSIL_1038Small primase-like protein. (108 aa)
SSIL_1085Predicted RNA binding protein. (124 aa)
SSIL_1093DnaK suppressor protein. (114 aa)
SSIL_1108Carbonic anhydrase/acetyltransferase, isoleucine patch superfamily. (170 aa)
ezrANegative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (567 aa)
SSIL_1176Exopolyphosphatase-related protein. (314 aa)
SSIL_1203Replication initiation/membrane attachment protein. (915 aa)
SSIL_1204DNA replication protein. (319 aa)
rpmIRibosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
deaDSuperfamily II DNA and RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (481 aa)
SSIL_1344DnaK suppressor protein. (227 aa)
SSIL_1387Predicted transcriptional regulator. (133 aa)
SSIL_2712Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (120 aa)
SSIL_2685Putative primosome component. (243 aa)
nthPredicted EndoIII-related endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa)
SSIL_2586Topoisomerase IA. (724 aa)
SSIL_2569Esterase/lipase. (324 aa)
SSIL_2565Signal transduction histidine kinase. (337 aa)
SSIL_2463Esterase/lipase. (295 aa)
SSIL_2414Predicted sugar phosphatase of the HAD superfamily. (423 aa)
SSIL_2406Nucleoside-diphosphate-sugar epimerase. (316 aa)
SSIL_2349Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (385 aa)
SSIL_2348NAD-dependent protein deacetylase, SIR2 family. (242 aa)
SSIL_2225MoxR-like ATPase. (372 aa)
parEType IIA topoisomerase, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (657 aa)
SSIL_2162Uridine kinase. (204 aa)
SSIL_2149Thiol-disulfide isomerase; Belongs to the thioredoxin family. (103 aa)
SSIL_2118Superfamily II DNA helicase. (587 aa)
SSIL_1878Esterase/lipase. (313 aa)
pdxSPyridoxine biosynthesis enzyme; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa)
SSIL_1726Uncharacterized conserved protein. (230 aa)
SSIL_1724FOG: TPR repeat. (163 aa)
recNATPase; May be involved in recombinational repair of damaged DNA. (563 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (419 aa)
rpmG-2Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
SSIL_1604ATPase. (426 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (82 aa)
SSIL_1528Deoxycytidylate deaminase. (191 aa)
udkUridine kinase. (211 aa)
dtdD-Tyr-tRNAtyr deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa)
rpmARibosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (98 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
radCDNA repair protein; Belongs to the UPF0758 family. (232 aa)
SSIL_1403Predicted ATPase. (796 aa)
SSIL_3777Predicted phosphohydrolase. (272 aa)
SSIL_3760NADPH-dependent glutamate synthase beta chain. (49 aa)
SSIL_3759Phytoene dehydrogenase. (497 aa)
SSIL_3667Nitric oxide synthase, oxygenase domain; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (359 aa)
SSIL_3666Predicted endonuclease. (184 aa)
SSIL_3582Predicted phosphohydrolase. (356 aa)
SSIL_3580Uncharacterized conserved protein. (265 aa)
SSIL_3519FOG: TPR repeat. (368 aa)
topBTopoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...] (732 aa)
SSIL_3463Nucleoside-diphosphate-sugar epimerase. (316 aa)
SSIL_3426HD superfamily phosphohydrolase. (435 aa)
SSIL_3409Uncharacterized conserved protein; Belongs to the Cob(I)alamin adenosyltransferase family. (186 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (66 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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