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murD murD mraY mraY SSIL_3101 SSIL_3101 SSIL_3102 SSIL_3102 ftsL ftsL murE murE SSIL_3135 SSIL_3135 murE-2 murE-2 ftsX ftsX ftsE ftsE murA-2 murA-2 murA murA SSIL_2662 SSIL_2662 murG murG SSIL_1585 SSIL_1585 SSIL_1478 SSIL_1478 minC minC engB engB tig tig SSIL_1270 SSIL_1270 zapA zapA ezrA ezrA murC murC whiA whiA murF murF SSIL_0406 SSIL_0406 scpB scpB scpA scpA xerD xerD murB murB noc noc spoVG spoVG SSIL_2676 SSIL_2676 xerC-2 xerC-2 divIVA divIVA sepF sepF ftsZ ftsZ ftsA ftsA divIB divIB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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murDUDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (450 aa)
mraYUDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (324 aa)
SSIL_3101Cell division protein FtsI/penicillin-binding protein 2. (638 aa)
SSIL_3102Cell division protein FtsI/penicillin-binding protein 2. (726 aa)
ftsLProtein required for the initiation of cell division; Essential cell division protein; Belongs to the FtsL family. (126 aa)
murEUDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (493 aa)
SSIL_3135Bacterial cell division membrane protein; Belongs to the SEDS family. (390 aa)
murE-2UDP-N-acetylmuramyl tripeptide synthase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (489 aa)
ftsXCell division protein; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (298 aa)
ftsEPredicted ATPase; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
murA-2UDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (425 aa)
murAUDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (433 aa)
SSIL_2662Cell division protein FtsI/penicillin-binding protein 2. (639 aa)
murGUDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (358 aa)
SSIL_1585Cell division protein FtsI/penicillin-binding protein 2. (736 aa)
SSIL_1478Bacterial cell division membrane protein; Belongs to the SEDS family. (428 aa)
minCSeptum formation inhibitor; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (222 aa)
engBPredicted GTPase; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (193 aa)
tigFKBP-type peptidyl-prolyl cis-trans isomerase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (429 aa)
SSIL_1270Bacterial cell division membrane protein. (152 aa)
zapAUncharacterized protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (86 aa)
ezrANegative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (567 aa)
murCUDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (432 aa)
whiAUncharacterized protein; Involved in cell division and chromosome segregation. (313 aa)
murFUDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa)
SSIL_0406Bacterial cell division membrane protein; Belongs to the SEDS family. (396 aa)
scpBPredicted transcriptional regulator containing the HTH domain; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (196 aa)
scpAUncharacterized conserved protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (260 aa)
xerDSite-specific recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (300 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (303 aa)
nocPredicted transcriptional regulator; Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage. Belongs to the ParB family. (294 aa)
spoVGUncharacterized protein; Could be involved in septation. (99 aa)
SSIL_2676Cell division initiation protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (105 aa)
xerC-2Site-specific recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (299 aa)
divIVACell division initiation protein. (181 aa)
sepFUncharacterized protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (178 aa)
ftsZCell division GTPase; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (387 aa)
ftsAActin-like ATPase; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (431 aa)
divIBCell division septal protein; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (288 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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