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SSIL_0015 SSIL_0015 prs prs SSIL_0077 SSIL_0077 SSIL_0078 SSIL_0078 guaB guaB purA purA adk adk guaA guaA purE purE purK purK SSIL_0476 SSIL_0476 purC purC yexA yexA purQ purQ purL purL purF purF purM purM purN purN purH purH purD purD SSIL_0489 SSIL_0489 SSIL_1054 SSIL_1054 SSIL_1132 SSIL_1132 SSIL_1268 SSIL_1268 SSIL_1338 SSIL_1338 apt apt SSIL_1495 SSIL_1495 SSIL_1641 SSIL_1641 SSIL_1643 SSIL_1643 SSIL_1861 SSIL_1861 deoD deoD SSIL_2221 SSIL_2221 guaC guaC SSIL_2469 SSIL_2469 SSIL_2470 SSIL_2470 SSIL_2624 SSIL_2624 SSIL_2643 SSIL_2643 ndk ndk deoB deoB SSIL_2794 SSIL_2794 SSIL_2826 SSIL_2826 gmk gmk SSIL_3176 SSIL_3176 SSIL_3226 SSIL_3226 xpt xpt SSIL_3681 SSIL_3681 ade ade
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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SSIL_0015Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
SSIL_0077Deoxynucleoside kinase. (222 aa)
SSIL_0078Deoxynucleoside kinase. (212 aa)
guaBIMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
guaAGMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (544 aa)
purEPhosphoribosylcarboxyaminoimidazole mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (374 aa)
SSIL_0476Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Belongs to the SAICAR synthetase family. (236 aa)
yexAPhosphoribosylformylglycinamidine synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thoug [...] (81 aa)
purQPhosphoribosylformylglycinamidine synthase, glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ an [...] (227 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is th [...] (743 aa)
purFGlutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (472 aa)
purMPhosphoribosylaminoimidazole synthetase. (351 aa)
purNFolate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa)
purHAICAR transformylase/IMP cyclohydrolase PurH. (511 aa)
purDPhosphoribosylamine-glycine ligase; Belongs to the GARS family. (416 aa)
SSIL_0489Adenine deaminase. (577 aa)
SSIL_10545'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (454 aa)
SSIL_1132Uncharacterized conserved protein. (204 aa)
SSIL_1268Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
SSIL_13385'-nucleotidase/2',3'-cyclic phosphodiesterase. (787 aa)
aptAdenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
SSIL_1495Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (731 aa)
SSIL_1641Ribonucleotide reductase, alpha subunit; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (661 aa)
SSIL_1643Ribonucleotide reductase, alpha subunit. (207 aa)
SSIL_1861NTP pyrophosphohydrolase including oxidative damage repair enzyme; Belongs to the Nudix hydrolase family. (204 aa)
deoDPurine-nucleoside phosphorylase. (235 aa)
SSIL_22215'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (717 aa)
guaCIMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
SSIL_2469Ribonucleotide reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (697 aa)
SSIL_2470Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa)
SSIL_2624Ribonucleotide reductase, beta subunit. (294 aa)
SSIL_2643Phosphoribosylaminoimidazolesuccinocarboxamide synthase. (228 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa)
SSIL_2794NTP pyrophosphohydrolase including oxidative damage repair enzyme. (181 aa)
SSIL_28265'-nucleotidase/2',3'-cyclic phosphodiesterase; Belongs to the 5'-nucleotidase family. (480 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)
SSIL_3176Exopolyphosphatase. (517 aa)
SSIL_3226Uncharacterized protein. (225 aa)
xptAdenine/guanine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
SSIL_3681Hydantoin racemase. (281 aa)
adeAdenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (581 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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