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hisZ hisZ hisG hisG hisD hisD hisB hisB hisH hisH hisF hisF hisIE hisIE hutH hutH SSIL_1159 SSIL_1159 SSIL_1499 SSIL_1499 SSIL_1761 SSIL_1761 SSIL_1880 SSIL_1880 SSIL_2519 SSIL_2519 hisC hisC SSIL_3201 SSIL_3201 hutI hutI hutU hutU
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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hisZATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa)
hisBImidazoleglycerol-phosphate dehydratase. (197 aa)
hisHGlutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa)
hisFImidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisIEphosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (205 aa)
hutHHistidine ammonia-lyase. (494 aa)
SSIL_1159Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (267 aa)
SSIL_1499Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase; Belongs to the HisA/HisF family. (261 aa)
SSIL_1761NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (440 aa)
SSIL_1880NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
SSIL_2519NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (475 aa)
hisCHistidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
SSIL_3201NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (462 aa)
hutIImidazolonepropionase. (422 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (553 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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