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argC argC argJ argJ argB argB argD argD SSIL_1185 SSIL_1185 SSIL_1186 SSIL_1186 SSIL_1258 SSIL_1258 ilvD ilvD SSIL_2044 SSIL_2044 SSIL_2045 SSIL_2045 ilvC ilvC leuB leuB leuC leuC leuD leuD SSIL_2222 SSIL_2222 leuA leuA SSIL_2408 SSIL_2408 SSIL_2585 SSIL_2585 SSIL_2687 SSIL_2687 ywaA ywaA asd asd SSIL_3495 SSIL_3495
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
argCAcetylglutamate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (258 aa)
argDOrnithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (383 aa)
SSIL_1185Citrate synthase; Belongs to the citrate synthase family. (371 aa)
SSIL_1186Isocitrate dehydrogenase. (420 aa)
SSIL_1258Aspartokinase; Belongs to the aspartokinase family. (410 aa)
ilvDDihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa)
SSIL_2044Thiamine pyrophosphate-requiring enzyme. (582 aa)
SSIL_2045Acetolactate synthase, small subunit. (171 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
leuBIsocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa)
SSIL_2222Aconitase A; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (898 aa)
leuAIsopropylmalate/homocitrate/citramalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (529 aa)
SSIL_2408Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. (582 aa)
SSIL_2585Aspartokinase; Belongs to the aspartokinase family. (453 aa)
SSIL_2687Aspartate/tyrosine/aromatic aminotransferase. (397 aa)
ywaABranched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (356 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
SSIL_3495Transcriptional regulator containing a DNA-binding HTH domain and an aminotransferase domain. (388 aa)
Your Current Organism:
Solibacillus silvestris
NCBI taxonomy Id: 1002809
Other names: S. silvestris StLB046, Solibacillus silvestris StLB046, Solibacillus silvestris str. StLB046, Solibacillus silvestris strain StLB046
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