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| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (206 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisIE | phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (205 aa) |
| | SSIL_0773 | Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | gpmI | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (513 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | SSIL_0933 | Methionine synthase II. (367 aa) |
| | luxS | LuxS protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (156 aa) |
| | gltA | Glutamate synthase domain 2. (1506 aa) |
| | gltB | NADPH-dependent glutamate synthase beta chain. (493 aa) |
| | SSIL_1081 | Biproductal PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. (392 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (398 aa) |
| | SSIL_1124 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (464 aa) |
| | SSIL_1141 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (361 aa) |
| | argC | Acetylglutamate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (258 aa) |
| | argD | Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (383 aa) |
| | SSIL_1159 | Histidinol phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (267 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | SSIL_1185 | Citrate synthase; Belongs to the citrate synthase family. (371 aa) |
| | SSIL_1186 | Isocitrate dehydrogenase. (420 aa) |
| | SSIL_1201 | Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa) |
| | SSIL_1222 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (322 aa) |
| | SSIL_1258 | Aspartokinase; Belongs to the aspartokinase family. (410 aa) |
| | SSIL_1363 | Saccharopine dehydrogenase. (409 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | pheB | ACT domain-containing protein; Belongs to the UPF0735 family. (151 aa) |
| | pheA | Prephenate dehydratase. (290 aa) |
| | SSIL_1499 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase; Belongs to the HisA/HisF family. (261 aa) |
| | mtnN | Nucleoside phosphorylase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (280 aa) |
| | glnA | Glutamine synthetase. (444 aa) |
| | SSIL_1560 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | trpE | Anthranilate/para-aminobenzoate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismat [...] (462 aa) |
| | SSIL_1612 | Anthranilate/para-aminobenzoate synthase component II. (193 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | SSIL_2037 | Cystathionine beta-lyase/cystathionine gamma-synthase. (387 aa) |
| | SSIL_2038 | Cystathionine beta-lyase/cystathionine gamma-synthase. (371 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | SSIL_2044 | Thiamine pyrophosphate-requiring enzyme. (582 aa) |
| | SSIL_2045 | Acetolactate synthase, small subunit. (171 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | leuB | Isocitrate/isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (320 aa) |
| | SSIL_2124 | Aspartate/tyrosine/aromatic aminotransferase. (387 aa) |
| | metAA | Homoserine trans-succinylase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (313 aa) |
| | SSIL_2217 | Meso-diaminopimelate D-dehydrogenase; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. (327 aa) |
| | SSIL_2222 | Aconitase A; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (898 aa) |
| | leuA | Isopropylmalate/homocitrate/citramalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (529 aa) |
| | SSIL_2342 | Threonine dehydratase. (319 aa) |
| | argH | Argininosuccinate lyase. (457 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (404 aa) |
| | proC-2 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | SSIL_2408 | Thiamine pyrophosphate-requiring enzyme; Belongs to the TPP enzyme family. (582 aa) |
| | SSIL_2457 | Fructose-2,6-bisphosphatase. (178 aa) |
| | SSIL_2559 | Serine acetyltransferase. (309 aa) |
| | SSIL_2585 | Aspartokinase; Belongs to the aspartokinase family. (453 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | SSIL_2687 | Aspartate/tyrosine/aromatic aminotransferase. (397 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (265 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | SSIL_2710 | Prephenate dehydrogenase. (365 aa) |
| | hisC | Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | SSIL_2712 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (120 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (393 aa) |
| | SSIL_2764 | Glutamine synthetase. (452 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (439 aa) |
| | luxS-2 | LuxS protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa) |
| | ywaA | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (356 aa) |
| | dapA | Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa) |
| | SSIL_3040 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (306 aa) |
| | SSIL_3041 | L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa) |
| | SSIL_3047 | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | SSIL_3134 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa) |
| | SSIL_3169 | Metal-dependent amidase/aminoacylase/carboxypeptidase; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (373 aa) |
| | dapH | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (237 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | SSIL_3383 | Ribose 5-phosphate isomerase RpiB. (146 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | SSIL_3397 | Fructose/tagatose bisphosphate aldolase. (284 aa) |
| | SSIL_0010 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | SSIL_3449 | Anthranilate/para-aminobenzoate synthase component I. (327 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (264 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (259 aa) |
| | SSIL_3589 | Homoserine dehydrogenase. (328 aa) |
| | argH-2 | Argininosuccinate lyase. (507 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | SSIL_0095 | Asparagine synthase. (608 aa) |
| | SSIL_0265 | Arginase/agmatinase/formimionoglutamate hydrolase; Belongs to the arginase family. (301 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (299 aa) |
| | SSIL_0381 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | SSIL_0446 | 5,10-methylenetetrahydrofolate reductase. (614 aa) |
| | SSIL_0447 | Methionine synthase I, cobalamin-binding domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1143 aa) |
| | SSIL_0691 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (541 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa) |
| | hisZ | ATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (207 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
