(37 nodes) Abdomen network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tgfb1	Transforming growth factor beta-1. (237 aa)
	Acan	Aggrecan core protein. (2120 aa)
	Rpl13a	60S ribosomal protein L13a. (117 aa)
	Adipoq	Adiponectin. (248 aa)
	Ins	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
	Perm1	Uncharacterized protein C1orf170-like. (719 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	I79_015109	Interleukin-6. (174 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Sgsh	N-sulphoglucosamine sulphohydrolase. (502 aa)
	Gadd45b	Growth arrest and DNA-damage-inducible protein GADD45 beta. (232 aa)
	Sri	Sorcin. (117 aa)
	Crisp1	Cysteine-rich secretory protein 1. (124 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	I79_011955	60S ribosomal protein L13a. (112 aa)
	I79_010756	Galectin. (283 aa)
	Lsm11	U7 snRNA-associated Sm-like protein LSm11. (211 aa)
	I79_008865	60S ribosomal protein L13a. (138 aa)
	I79_008640	NF-kappa-B inhibitor alpha. (90 aa)
	I79_008639	NF-kappa-B inhibitor alpha. (52 aa)
	Cacna1a	Voltage-dependent P/Q-type calcium channel subunit alpha-1A. (78 aa)
	I79_008310	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1939 aa)
	I79_008232	EGF-like module-containing mucin-like hormone receptor-like 1; Belongs to the G-protein coupled receptor 2 family. (944 aa)
	Il10	Interleukin-10. (178 aa)
	I79_007196	60S ribosomal protein L13a. (146 aa)
	Lcp1	Plastin-2. (872 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	I79_023559	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1496 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Cdh15	Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
	Il17a	Interleukin-17A. (158 aa)
	I79_017300	Integrin alpha-E; Belongs to the integrin alpha chain family. (1000 aa)
	Nfkbia	NF-kappa-B inhibitor alpha. (224 aa)
	I79_018243	Odorant-binding protein; Belongs to the calycin superfamily. Lipocalin family. (174 aa)
	Cilk1	Serine/threonine-protein kinase ICK. (629 aa)
	Cacna1b	Voltage-dependent N-type calcium channel subunit alpha-1B. (244 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Acan	I79_015109	G3ICD5	G3HVW6	Aggrecan core protein.	Interleukin-6.	0.405
Acan	Ins	G3ICD5	G3HXZ8	Aggrecan core protein.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.410
Acan	Tgfb1	G3ICD5	G3IA12	Aggrecan core protein.	Transforming growth factor beta-1.	0.480
Adipoq	Cd4	G3HYG0	G3GUN9	Adiponectin.	T-cell surface glycoprotein CD4.	0.458
Adipoq	I79_015109	G3HYG0	G3HVW6	Adiponectin.	Interleukin-6.	0.765
Adipoq	Ifng	G3HYG0	G3GY20	Adiponectin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.405
Adipoq	Il10	G3HYG0	G3HB01	Adiponectin.	Interleukin-10.	0.612
Adipoq	Ins	G3HYG0	G3HXZ8	Adiponectin.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.932
Adipoq	Lep	G3HYG0	G3GZ86	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.974
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Adipoq	Tlr4	G3HYG0	G3I192	Adiponectin.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.485
Cacna1a	Cacna1b	G3HCZ1	G3I5Z3	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent N-type calcium channel subunit alpha-1B.	0.900
Cacna1a	Cdh15	G3HCZ1	G3GRS1	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins.	0.641
Cacna1a	I79_023559	G3HCZ1	G3II91	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.871
Cacna1a	Ins	G3HCZ1	G3HXZ8	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.901
Cacna1b	Cacna1a	G3I5Z3	G3HCZ1	Voltage-dependent N-type calcium channel subunit alpha-1B.	Voltage-dependent P/Q-type calcium channel subunit alpha-1A.	0.900
Cacna1b	I79_023559	G3I5Z3	G3II91	Voltage-dependent N-type calcium channel subunit alpha-1B.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.403
Cacna1b	Ins	G3I5Z3	G3HXZ8	Voltage-dependent N-type calcium channel subunit alpha-1B.	Multifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family.	0.901
Cd4	Adipoq	G3GUN9	G3HYG0	T-cell surface glycoprotein CD4.	Adiponectin.	0.458
Cd4	Foxp3	G3GUN9	G3HNB1	T-cell surface glycoprotein CD4.	Forkhead box protein P3.	0.966