STRINGSTRING
C1H6orf89 C1H6orf89 Thap1 Thap1 Lep Lep I79_000858 I79_000858 Rpl10 Rpl10 I79_021029 I79_021029 I79_019444 I79_019444 Stx4 Stx4 Fabp4 Fabp4 I79_016799 I79_016799 CgPICR_010886 CgPICR_010886 Adipoq Adipoq I79_015970 I79_015970 Ins Ins PPARG PPARG Flot1 Flot1 I79_012798 I79_012798 Ap3s1 Ap3s1 Rsu1 Rsu1 I79_011983 I79_011983 Aoc3 Aoc3 Tcf3 Tcf3 I79_007352 I79_007352 I79_006456 I79_006456 I79_021287 I79_021287 Scyl1 Scyl1 Rras Rras Stxbp3 Stxbp3 Plin2 Plin2 Tpra1 Tpra1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1H6orf89Uncharacterized protein C6orf89-like. (348 aa)
Thap1THAP domain-containing protein 1. (94 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
I79_00085860S ribosomal protein L10. (110 aa)
Rpl1060S ribosomal protein L10. (163 aa)
I79_02102960S ribosomal protein L10. (258 aa)
I79_01944460S ribosomal protein L10. (124 aa)
Stx4Syntaxin-4; Belongs to the syntaxin family. (298 aa)
Fabp4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
I79_01679960S ribosomal protein L10. (100 aa)
CgPICR_01088660S ribosomal protein L10. (101 aa)
AdipoqAdiponectin. (248 aa)
I79_01597060S ribosomal protein L10. (76 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Flot1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (418 aa)
I79_012798TC10/CDC42 GTPase-activating protein. (999 aa)
Ap3s1AP-3 complex subunit sigma-1. (157 aa)
Rsu1Ras suppressor protein 1. (277 aa)
I79_01198360S ribosomal protein L10. (102 aa)
Aoc3Amine oxidase. (763 aa)
Tcf3Transcription factor E2-alpha. (643 aa)
I79_00735260S ribosomal protein L10. (204 aa)
I79_006456Integral membrane protein GPR175. (67 aa)
I79_02128760S ribosomal protein L10-like. (97 aa)
Scyl1SCYL1. (805 aa)
RrasRas-related protein R-Ras. (126 aa)
Stxbp3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
Plin2Perilipin; Belongs to the perilipin family. (432 aa)
Tpra1Integral membrane protein GPR175. (112 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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