(22 nodes) Natural killer cell network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Prf1	Perforin-1. (555 aa)
	I79_006470	Natural killer cell receptor 2B4. (280 aa)
	I79_005715	F-box/LRR-repeat protein 20. (308 aa)
	Nrip1	Nuclear receptor-interacting protein 1. (1172 aa)
	Ahnak2	Protein AHNAK2. (763 aa)
	I79_002900	Nuclear pore complex protein Nup160. (1215 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Fig4	Polyphosphoinositide phosphatase. (907 aa)
	Kcng3	Potassium voltage-gated channel subfamily G member 3; Belongs to the potassium channel family. (166 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	I79_001341	Killer cell lectin-like receptor subfamily B member 1A. (133 aa)
	I79_000136	Uncharacterized protein KIAA1370. (977 aa)
	I79_018993	Interleukin-23 receptor. (380 aa)
	Ddi1	Protein DDI1-like 1. (331 aa)
	I79_015541	Protein FAM92A1. (243 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	I79_011620	Formin-like protein 1. (1012 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	I79_009584	Platelet endothelial aggregation receptor 1. (821 aa)
	Il10	Interleukin-10. (178 aa)
	Rassf5	Ras association domain-containing protein 5. (246 aa)
	Rnf19b	RBR-type E3 ubiquitin transferase. (553 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	I79_006470	G3GUN9	G3H7X4	T-cell surface glycoprotein CD4.	Natural killer cell receptor 2B4.	0.586
Cd4	I79_018993	G3GUN9	G3I681	T-cell surface glycoprotein CD4.	Interleukin-23 receptor.	0.727
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il15	G3GUN9	G3HJ60	T-cell surface glycoprotein CD4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.915
Cd4	Prf1	G3GUN9	G3H6S0	T-cell surface glycoprotein CD4.	Perforin-1.	0.625
I79_001341	Ifng	G3GUH9	G3GY20	Killer cell lectin-like receptor subfamily B member 1A.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.441
I79_006470	Cd4	G3H7X4	G3GUN9	Natural killer cell receptor 2B4.	T-cell surface glycoprotein CD4.	0.586
I79_018993	Cd4	G3I681	G3GUN9	Interleukin-23 receptor.	T-cell surface glycoprotein CD4.	0.727
I79_018993	Ifng	G3I681	G3GY20	Interleukin-23 receptor.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.582
I79_018993	Il10	G3I681	G3HB01	Interleukin-23 receptor.	Interleukin-10.	0.592
IL2	Cd4	G3HTL8	G3GUN9	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	T-cell surface glycoprotein CD4.	0.974
IL2	Ifng	G3HTL8	G3GY20	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
IL2	Il10	G3HTL8	G3HB01	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin-10.	0.947
IL2	Il15	G3HTL8	G3HJ60	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Interleukin; Belongs to the IL-15/IL-21 family.	0.901
IL2	Prf1	G3HTL8	G3H6S0	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Perforin-1.	0.569
Ifng	Cd4	G3GY20	G3GUN9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	T-cell surface glycoprotein CD4.	0.966
Ifng	I79_001341	G3GY20	G3GUH9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Killer cell lectin-like receptor subfamily B member 1A.	0.441
Ifng	I79_018993	G3GY20	G3I681	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-23 receptor.	0.582