(7 nodes) Splenocyte network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Il10	Interleukin-10. (178 aa)
	I79_019428	Integrin alpha-X; Belongs to the integrin alpha chain family. (1016 aa)
	Il17a	Interleukin-17A. (158 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Foxp3	G3GUN9	G3HNB1	T-cell surface glycoprotein CD4.	Forkhead box protein P3.	0.966
Cd4	I79_019428	G3GUN9	G3I7E0	T-cell surface glycoprotein CD4.	Integrin alpha-X; Belongs to the integrin alpha chain family.	0.561
Cd4	IL2	G3GUN9	G3HTL8	T-cell surface glycoprotein CD4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.974
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il10	G3GUN9	G3HB01	T-cell surface glycoprotein CD4.	Interleukin-10.	0.968
Cd4	Il17a	G3GUN9	G3I1H2	T-cell surface glycoprotein CD4.	Interleukin-17A.	0.888
Foxp3	Cd4	G3HNB1	G3GUN9	Forkhead box protein P3.	T-cell surface glycoprotein CD4.	0.966
Foxp3	I79_019428	G3HNB1	G3I7E0	Forkhead box protein P3.	Integrin alpha-X; Belongs to the integrin alpha chain family.	0.497
Foxp3	IL2	G3HNB1	G3HTL8	Forkhead box protein P3.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.947
Foxp3	Ifng	G3HNB1	G3GY20	Forkhead box protein P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.931
Foxp3	Il10	G3HNB1	G3HB01	Forkhead box protein P3.	Interleukin-10.	0.921
Foxp3	Il17a	G3HNB1	G3I1H2	Forkhead box protein P3.	Interleukin-17A.	0.722
I79_019428	Cd4	G3I7E0	G3GUN9	Integrin alpha-X; Belongs to the integrin alpha chain family.	T-cell surface glycoprotein CD4.	0.561
I79_019428	Foxp3	G3I7E0	G3HNB1	Integrin alpha-X; Belongs to the integrin alpha chain family.	Forkhead box protein P3.	0.497
I79_019428	IL2	G3I7E0	G3HTL8	Integrin alpha-X; Belongs to the integrin alpha chain family.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.445
I79_019428	Ifng	G3I7E0	G3GY20	Integrin alpha-X; Belongs to the integrin alpha chain family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.556
I79_019428	Il10	G3I7E0	G3HB01	Integrin alpha-X; Belongs to the integrin alpha chain family.	Interleukin-10.	0.491
I79_019428	Il17a	G3I7E0	G3I1H2	Integrin alpha-X; Belongs to the integrin alpha chain family.	Interleukin-17A.	0.426
IL2	Cd4	G3HTL8	G3GUN9	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	T-cell surface glycoprotein CD4.	0.974
IL2	Foxp3	G3HTL8	G3HNB1	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	Forkhead box protein P3.	0.947