(8 nodes) Th17 cell network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_018993	Interleukin-23 receptor. (380 aa)
	Cd4	T-cell surface glycoprotein CD4. (447 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Foxp3	Forkhead box protein P3. (428 aa)
	I79_015109	Interleukin-6. (174 aa)
	Il17f	Interleukin-17F. (161 aa)
	Il17a	Interleukin-17A. (158 aa)
	I79_021840	Nuclear receptor ROR-gamma. (341 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cd4	Foxp3	G3GUN9	G3HNB1	T-cell surface glycoprotein CD4.	Forkhead box protein P3.	0.966
Cd4	I79_015109	G3GUN9	G3HVW6	T-cell surface glycoprotein CD4.	Interleukin-6.	0.849
Cd4	I79_018993	G3GUN9	G3I681	T-cell surface glycoprotein CD4.	Interleukin-23 receptor.	0.727
Cd4	I79_021840	G3GUN9	G3IDQ7	T-cell surface glycoprotein CD4.	Nuclear receptor ROR-gamma.	0.668
Cd4	Ifng	G3GUN9	G3GY20	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.966
Cd4	Il17a	G3GUN9	G3I1H2	T-cell surface glycoprotein CD4.	Interleukin-17A.	0.888
Cd4	Il17f	G3GUN9	G3I1H1	T-cell surface glycoprotein CD4.	Interleukin-17F.	0.844
Foxp3	Cd4	G3HNB1	G3GUN9	Forkhead box protein P3.	T-cell surface glycoprotein CD4.	0.966
Foxp3	I79_015109	G3HNB1	G3HVW6	Forkhead box protein P3.	Interleukin-6.	0.673
Foxp3	I79_021840	G3HNB1	G3IDQ7	Forkhead box protein P3.	Nuclear receptor ROR-gamma.	0.586
Foxp3	Ifng	G3HNB1	G3GY20	Forkhead box protein P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.931
Foxp3	Il17a	G3HNB1	G3I1H2	Forkhead box protein P3.	Interleukin-17A.	0.722
Foxp3	Il17f	G3HNB1	G3I1H1	Forkhead box protein P3.	Interleukin-17F.	0.574
I79_015109	Cd4	G3HVW6	G3GUN9	Interleukin-6.	T-cell surface glycoprotein CD4.	0.849
I79_015109	Foxp3	G3HVW6	G3HNB1	Interleukin-6.	Forkhead box protein P3.	0.673
I79_015109	I79_018993	G3HVW6	G3I681	Interleukin-6.	Interleukin-23 receptor.	0.433
I79_015109	Ifng	G3HVW6	G3GY20	Interleukin-6.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.878
I79_015109	Il17a	G3HVW6	G3I1H2	Interleukin-6.	Interleukin-17A.	0.705
I79_015109	Il17f	G3HVW6	G3I1H1	Interleukin-6.	Interleukin-17F.	0.613
I79_018993	Cd4	G3I681	G3GUN9	Interleukin-23 receptor.	T-cell surface glycoprotein CD4.	0.727