STRINGSTRING
I79_000224 I79_000224 Nt5e Nt5e Gmpr Gmpr Entpd4 Entpd4 Adk Adk Ntpcr Ntpcr I79_002513 I79_002513 IMPDH IMPDH CgPICR_013214 CgPICR_013214 Entpd1 Entpd1 Adal Adal Gmps Gmps Cant1 Cant1 ITPA ITPA I79_005654 I79_005654 Adss2 Adss2 Pde10a Pde10a Ak2 Ak2 Pde6c Pde6c H671_7g18194 H671_7g18194 CgPICR_020542 CgPICR_020542 Nme3 Nme3 I79_008219 I79_008219 Ctps1 Ctps1 GMPR GMPR Thtpa Thtpa Hprt1 Hprt1 Pde1c Pde1c Nme6 Nme6 Rrm2b Rrm2b Ada Ada Nt5c3b Nt5c3b Nt5c3a Nt5c3a Nt5c1a Nt5c1a Entpd5 Entpd5 I79_012333 I79_012333 I79_013073 I79_013073 AK3 AK3 Ak1 Ak1 Adsl Adsl Tpk1 Tpk1 I79_015701 I79_015701 Ak4 Ak4 Ampd3 Ampd3 Nme7 Nme7 Pde2a Pde2a I79_017168 I79_017168 Atic Atic Ctps2 Ctps2 Rrm2 Rrm2 Rrm1 Rrm1 I79_018438 I79_018438 Entpd8 Entpd8 Pde1b Pde1b Ampd2 Ampd2 Nudt2 Nudt2 Enpp1 Enpp1 Dalrd3 Dalrd3 I79_021535 I79_021535 Ak8 Ak8 Paics Paics I79_022567 I79_022567 Hddc3 Hddc3 Entpd2 Entpd2 IMPDH2 IMPDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_000224Adenine phosphoribosyltransferase. (192 aa)
Nt5e5'-nucleotidase; Belongs to the 5'-nucleotidase family. (556 aa)
GmprGMP reductase 1. (106 aa)
Entpd4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (487 aa)
AdkAdenosine kinase. (361 aa)
NtpcrNucleoside-triphosphatase C1orf57. (190 aa)
I79_002513Uncharacterized protein C6orf224. (1162 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (437 aa)
CgPICR_013214U8 snoRNA-decapping enzyme. (181 aa)
Entpd1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (269 aa)
AdalAdenosine deaminase-like protein. (355 aa)
GmpsGMP synthase [glutamine-hydrolyzing]. (1159 aa)
Cant1Soluble calcium-activated nucleotidase 1. (400 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (196 aa)
I79_005654S-methyl-5'-thioadenosine phosphorylase. (88 aa)
Adss2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (355 aa)
Pde10aPhosphodiesterase. (710 aa)
Ak2Adenylate kinase 2, mitochondrial; Belongs to the adenylate kinase family. (142 aa)
Pde6cPhosphodiesterase. (977 aa)
H671_7g18194Nucleoside diphosphate kinase. (152 aa)
CgPICR_020542Nucleoside diphosphate kinase. (152 aa)
Nme3Nucleoside diphosphate kinase. (169 aa)
I79_008219Adenylate kinase isoenzyme 1; Belongs to the adenylate kinase family. (200 aa)
Ctps1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
ThtpaThiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (224 aa)
Hprt1Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
Pde1cPhosphodiesterase. (583 aa)
Nme6Nucleoside diphosphate kinase. (186 aa)
Rrm2bRibonucleoside-diphosphate reductase subunit M2 B. (114 aa)
AdaAdenosine deaminase. (363 aa)
Nt5c3b5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
Nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (308 aa)
Nt5c1aCytosolic 5'-nucleotidase 1A. (365 aa)
Entpd5Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (453 aa)
I79_012333Epoxide hydrolase 2. (464 aa)
I79_013073AMP deaminase 1. (78 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
Ak1Adenylate kinase isoenzyme 1; Belongs to the adenylate kinase family. (54 aa)
AdslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
Tpk1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
I79_015701CTP synthase 2. (185 aa)
Ak4Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (161 aa)
Ampd3AMP deaminase 3. (102 aa)
Nme7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (160 aa)
Pde2acGMP-dependent 3',5'-cyclic phosphodiesterase; Belongs to the cyclic nucleotide phosphodiesterase family. (216 aa)
I79_0171685_nucleotid_C domain-containing protein. (240 aa)
AticBifunctional purine biosynthesis protein PURH. (592 aa)
Ctps2CTP synthase 2. (362 aa)
Rrm2Ribonucleoside-diphosphate reductase subunit M2. (390 aa)
Rrm1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
I79_018438Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (202 aa)
Entpd8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (466 aa)
Pde1bPDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (117 aa)
Ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa)
Nudt2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
Dalrd3DALR anticodon-binding domain-containing protein 3. (458 aa)
I79_021535Phosphoribosyltransferase domain-containing protein 1. (80 aa)
Ak8Putative adenylate kinase-like protein C9orf98-like; Belongs to the adenylate kinase family. (374 aa)
PaicsMultifunctional protein ADE2. (87 aa)
I79_022567Amidophosphoribosyltransferase. (90 aa)
Hddc3HD domain-containing protein 3. (179 aa)
Entpd2Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (485 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. (514 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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