(23 nodes) Purine metabolism network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Nt5e	5'-nucleotidase; Belongs to the 5'-nucleotidase family. (556 aa)
	Gmpr	GMP reductase 1. (106 aa)
	Entpd4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (487 aa)
	IMPDH	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (437 aa)
	CgPICR_013214	U8 snoRNA-decapping enzyme. (181 aa)
	Entpd1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (269 aa)
	Gmps	GMP synthase [glutamine-hydrolyzing]. (1159 aa)
	Cant1	Soluble calcium-activated nucleotidase 1. (400 aa)
	ITPA	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (196 aa)
	Adss2	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (355 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
	Hprt1	Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
	Nt5c3b	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
	Nt5c3a	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (308 aa)
	Nt5c1a	Cytosolic 5'-nucleotidase 1A. (365 aa)
	Entpd5	Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (453 aa)
	Ampd3	AMP deaminase 3. (102 aa)
	Nme7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (160 aa)
	Atic	Bifunctional purine biosynthesis protein PURH. (592 aa)
	Entpd8	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (466 aa)
	Ampd2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa)
	Enpp1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
	IMPDH2	Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. (514 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adss2	Ampd2	G3H7M3	G3I798	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.948
Adss2	Ampd3	G3H7M3	G3HYL7	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	AMP deaminase 3.	0.948
Adss2	Atic	G3H7M3	G3I1V4	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Bifunctional purine biosynthesis protein PURH.	0.999
Adss2	Cant1	G3H7M3	G3H3E3	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Soluble calcium-activated nucleotidase 1.	0.910
Adss2	CgPICR_013214	G3H7M3	G3GZI1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	U8 snoRNA-decapping enzyme.	0.901
Adss2	Entpd1	G3H7M3	G3GZT9	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family.	0.905
Adss2	Entpd4	G3H7M3	G3GUZ2	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family.	0.905
Adss2	Entpd5	G3H7M3	G3HNI0	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family.	0.923
Adss2	Entpd8	G3H7M3	G3I5Y1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family.	0.905
Adss2	GMPR	G3H7M3	G3HDD3	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.988
Adss2	Gmpr	G3H7M3	G3GUF3	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	GMP reductase 1.	0.988
Adss2	Gmps	G3H7M3	G3H229	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	GMP synthase [glutamine-hydrolyzing].	0.780
Adss2	Hprt1	G3H7M3	G3HGI4	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Hypoxanthine-guanine phosphoribosyltransferase.	0.968
Adss2	IMPDH	G3H7M3	G3GZ89	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.	0.983
Adss2	IMPDH2	G3H7M3	P12269	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family.	0.972
Adss2	ITPA	G3H7M3	G3H436	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.973
Adss2	Nt5c1a	G3H7M3	G3HN79	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Cytosolic 5'-nucleotidase 1A.	0.910
Adss2	Nt5c3a	G3H7M3	G3HMQ1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.901
Adss2	Nt5c3b	G3H7M3	G3HLV2	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.901
Adss2	Nt5e	G3H7M3	G3GTC0	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	5'-nucleotidase; Belongs to the 5'-nucleotidase family.	0.939