(64 nodes) Mixed, incl. Plasma lipoprotein particle, and Cholesterol metabolism network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (691 aa)
	I79_001015	Low-density lipoprotein receptor-related protein 8. (764 aa)
	Abca1	ATP-binding cassette sub-family A member 1. (2261 aa)
	I79_001239	Low-density lipoprotein receptor-related protein 2. (4664 aa)
	Mylip	E3 ubiquitin-protein ligase MYLIP. (417 aa)
	Abcg8	ATP-binding cassette sub-family G member 8. (951 aa)
	Lrpap1	Alpha-2-macroglobulin receptor-associated protein. (351 aa)
	I79_002139	Uncharacterized protein. (1290 aa)
	Gpr6	G-protein coupled receptor 6; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	I79_003225	Serotransferrin. (1227 aa)
	I79_003342	Apolipoprotein B-100. (946 aa)
	Apob	Apolipoprotein B-100. (3537 aa)
	I79_003637	Low-density lipoprotein receptor-related protein 4. (766 aa)
	Mbtps2	Membrane-bound transcription factor site-2 protease. (510 aa)
	Sparc	SPARC. (249 aa)
	Insig2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	Lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (450 aa)
	Pltp	Phospholipid transfer protein. (493 aa)
	I79_009834	Disabled-like 2. (705 aa)
	I79_010155	Sterol regulatory element-binding protein 1. (1050 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (492 aa)
	I79_010660	Oncoprotein-induced transcript 3 protein. (456 aa)
	Lpo	Lactoperoxidase. (226 aa)
	Scap	Sterol regulatory element-binding protein cleavage-activating protein. (1276 aa)
	Lcat	Phosphatidylcholine-sterol acyltransferase. (183 aa)
	Abcg1	ATP-binding cassette sub-family G member 1. (647 aa)
	Npc1l1	Niemann-Pick C1-like protein 1. (1328 aa)
	Clu	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
	Apoe	Apolipoprotein E. (313 aa)
	Apoc2	Apolipoprotein C-II. (100 aa)
	I79_013136	Stabilin-2. (1803 aa)
	Slc22a17	Solute carrier family 22 member 17. (252 aa)
	Apof	Apolipoprotein F. (303 aa)
	I79_014078	Niemann-Pick C1 protein. (1137 aa)
	Pon1	Serum paraoxonase/arylesterase 1. (355 aa)
	Ltf	Lactotransferrin; Belongs to the transferrin family. (648 aa)
	Apoa2	Apolipoprotein A-II-like protein. (101 aa)
	I79_015046	Low-density lipoprotein receptor. (160 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Apom	Apolipoprotein M. (90 aa)
	Ankra2	Ankyrin repeat family A protein 2. (97 aa)
	I79_017476	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
	I79_017477	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (120 aa)
	Vwa1	Von Willebrand factor A domain-containing protein 1. (446 aa)
	I79_018733	Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1. (247 aa)
	Angptl4	Angiopoietin-related protein 4. (411 aa)
	Ldlrap1	Low density lipoprotein receptor adapter protein 1. (263 aa)
	Apoa1	Apolipoprotein A-I. (264 aa)
	Apoc3	Apolipoprotein C-III. (76 aa)
	CgPICR_005982	Apolipoprotein A-IV. (230 aa)
	Apoa5	Apolipoprotein A-V. (363 aa)
	Npc2	Epididymal secretory protein E1. (149 aa)
	Frmd6	FERM domain-containing protein 6. (679 aa)
	Mesd	LDLR chaperone MESD. (226 aa)
	I79_020923	Low-density lipoprotein receptor-related protein 1B. (254 aa)
	Lcn2	Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (229 aa)
	I79_021093	Sterol regulatory element-binding protein 2. (2034 aa)
	H671_3g10030	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (204 aa)
	I79_022918	Low-density lipoprotein receptor-related protein 1B. (274 aa)
	I79_024392	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (179 aa)
	I79_024722	Low-density lipoprotein receptor-related protein 1B. (148 aa)
	I79_025297	Very low-density lipoprotein receptor. (558 aa)
	LDLR	Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
	MBTPS1	Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysos [...] (1052 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abca1	Abcg1	G3GTZ6	G3HLD6	ATP-binding cassette sub-family A member 1.	ATP-binding cassette sub-family G member 1.	0.500
Abca1	Abcg8	G3GTZ6	G3GV45	ATP-binding cassette sub-family A member 1.	ATP-binding cassette sub-family G member 8.	0.452
Abca1	Apoa1	G3GTZ6	G3I7Q1	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-I.	0.945
Abca1	Apoa2	G3GTZ6	G3HTY7	ATP-binding cassette sub-family A member 1.	Apolipoprotein A-II-like protein.	0.621
Abca1	Apob	G3GTZ6	G3GZQ0	ATP-binding cassette sub-family A member 1.	Apolipoprotein B-100.	0.782
Abca1	Apoc3	G3GTZ6	G3I7Q2	ATP-binding cassette sub-family A member 1.	Apolipoprotein C-III.	0.454
Abca1	Apoe	G3GTZ6	G3HPC9	ATP-binding cassette sub-family A member 1.	Apolipoprotein E.	0.882
Abca1	Apof	G3GTZ6	G3HRN8	ATP-binding cassette sub-family A member 1.	Apolipoprotein F.	0.404
Abca1	CETP	G3GTZ6	G3HIK4	ATP-binding cassette sub-family A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (By similarity). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.878
Abca1	I79_010155	G3GTZ6	G3HHP9	ATP-binding cassette sub-family A member 1.	Sterol regulatory element-binding protein 1.	0.567
Abca1	I79_014078	G3GTZ6	G3HT60	ATP-binding cassette sub-family A member 1.	Niemann-Pick C1 protein.	0.468
Abca1	I79_021093	G3GTZ6	G3IBR7	ATP-binding cassette sub-family A member 1.	Sterol regulatory element-binding protein 2.	0.692
Abca1	Insig2	G3GTZ6	G3H5D0	ATP-binding cassette sub-family A member 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.426
Abca1	Lcat	G3GTZ6	G3HKW5	ATP-binding cassette sub-family A member 1.	Phosphatidylcholine-sterol acyltransferase.	0.776
Abca1	Lpl	G3GTZ6	G3H6V7	ATP-binding cassette sub-family A member 1.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.480
Abca1	Mylip	G3GTZ6	G3GUF2	ATP-binding cassette sub-family A member 1.	E3 ubiquitin-protein ligase MYLIP.	0.468
Abca1	Npc1l1	G3GTZ6	G3HMB0	ATP-binding cassette sub-family A member 1.	Niemann-Pick C1-like protein 1.	0.825
Abca1	Npc2	G3GTZ6	G3I936	ATP-binding cassette sub-family A member 1.	Epididymal secretory protein E1.	0.437
Abca1	Pcsk9	G3GTZ6	G3GTK5	ATP-binding cassette sub-family A member 1.	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.	0.773
Abca1	Pltp	G3GTZ6	G3H8V4	ATP-binding cassette sub-family A member 1.	Phospholipid transfer protein.	0.722