(40 nodes) Mixed, incl. Regulation of beta-cell development, and Homeobox protein SIX1, N-terminal SD domain network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_000137	One cut domain family member. (431 aa)
	Six2	Homeobox protein SIX2. (299 aa)
	Pdx1	Pancreas/duodenum homeobox protein 1. (283 aa)
	Pax4	Paired box protein Pax-4. (231 aa)
	Pax6	Paired box protein Pax-6. (544 aa)
	I79_004195	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (501 aa)
	I79_004859	Protein atonal-like 1. (293 aa)
	Ptf1a	Pancreas transcription factor 1 subunit alpha. (152 aa)
	Neurog3	Neurogenin-3. (214 aa)
	Vsx1	Visual system homeobox 1. (226 aa)
	Eya2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (550 aa)
	Lhx1	LIM/homeobox protein Lhx1. (84 aa)
	I79_007350	Protein atonal-like 7. (65 aa)
	I79_009248	One cut domain family member 3. (170 aa)
	I79_010330	Hepatocyte nuclear factor 1-alpha. (668 aa)
	Foxn4	Forkhead box protein N4. (484 aa)
	I79_011183	Dachshund-like 1. (326 aa)
	I79_012324	Visual system homeobox 2. (361 aa)
	I79_012727	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (441 aa)
	I79_015239	X-linked interleukin-1 receptor accessory protein-like 2. (425 aa)
	Foxa2	Hepatocyte nuclear factor 3-beta. (430 aa)
	Hnf4a	Hepatocyte nuclear factor 4-alpha. (464 aa)
	Neurod4	Neurogenic differentiation factor. (331 aa)
	Barhl2	BarH-like 2 homeobox protein. (410 aa)
	Eya4	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (468 aa)
	Klf11	Krueppel-like factor 11. (485 aa)
	I79_017826	Dachshund-like 2. (125 aa)
	I79_018615	DNA-binding protein RFX6. (582 aa)
	Hnf1b	Hepatocyte nuclear factor 1-beta. (593 aa)
	Mnx1	Motor neuron and pancreas homeobox protein 1. (226 aa)
	I79_020506	POU domain, class 4, transcription factor 2. (207 aa)
	Six6	Homeobox protein SIX6. (246 aa)
	I79_022007	Homeobox protein SIX4. (673 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_022078	Homeobox protein Nkx-2.1. (190 aa)
	Pax8	Paired box protein Pax-8. (452 aa)
	Anhx	Homeobox protein SIX2. (256 aa)
	Ovgp1	Oviduct-specific glycoprotein. (615 aa)
	Sim1	Putative single-minded. (765 aa)
	I79_024779	Homeobox protein Nkx-6.1. (99 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anhx	Eya2	G3IFD0	G3H8T4	Homeobox protein SIX2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.572
Anhx	Eya4	G3IFD0	G3I268	Homeobox protein SIX2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.572
Anhx	I79_004195	G3IFD0	G3H1Z6	Homeobox protein SIX2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.572
Anhx	I79_012324	G3IFD0	G3HNI6	Homeobox protein SIX2.	Visual system homeobox 2.	0.514
Anhx	I79_012727	G3IFD0	G3HPL2	Homeobox protein SIX2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.572
Anhx	Pax6	G3IFD0	G3GZA8	Homeobox protein SIX2.	Paired box protein Pax-6.	0.432
Barhl2	Foxn4	G3I0Y5	G3HI84	BarH-like 2 homeobox protein.	Forkhead box protein N4.	0.472
Barhl2	I79_004859	G3I0Y5	G3H3N4	BarH-like 2 homeobox protein.	Protein atonal-like 1.	0.469
Barhl2	I79_020506	G3I0Y5	G3IA89	BarH-like 2 homeobox protein.	POU domain, class 4, transcription factor 2.	0.465
Barhl2	Ptf1a	G3I0Y5	G3H5C8	BarH-like 2 homeobox protein.	Pancreas transcription factor 1 subunit alpha.	0.601
Eya2	Anhx	G3H8T4	G3IFD0	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX2.	0.572
Eya2	Eya4	G3H8T4	G3I268	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.441
Eya2	I79_004195	G3H8T4	G3H1Z6	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.522
Eya2	I79_011183	G3H8T4	G3HKG3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Dachshund-like 1.	0.480
Eya2	I79_012727	G3H8T4	G3HPL2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.412
Eya2	I79_017826	G3H8T4	G3I326	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Dachshund-like 2.	0.550
Eya2	I79_022007	G3H8T4	G3IE64	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX4.	0.764
Eya2	Six1	G3H8T4	G3IE65	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX1.	0.824
Eya2	Six2	G3H8T4	G3GV57	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX2.	0.721
Eya2	Six6	G3H8T4	G3IBN3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Homeobox protein SIX6.	0.572