(32 nodes) Mixed, incl. Positive regulation of mesenchymal stem cell differentiation, and Forebrain neuron fate commitment network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_000368	Microphthalmia-associated transcription factor. (106 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Dlx1	Homeobox protein DLX-1. (255 aa)
	Dlx2	Homeobox protein DLX-2. (347 aa)
	Ctdspl	CTD small phosphatase-like protein. (239 aa)
	Msx1	Homeobox protein MSX-1. (261 aa)
	I79_002107	GS homeobox 1. (112 aa)
	Neurog1	Neurogenin-1. (241 aa)
	Msx2	Homeobox protein MSX-2. (267 aa)
	Cux2	Homeobox protein cut-like. (1422 aa)
	I79_004750	Transcription factor SOX-5. (211 aa)
	Sox5	Transcription factor SOX-5. (347 aa)
	I79_005719	Neurogenic differentiation factor 2. (352 aa)
	CgPICR_006170	Fez family zinc finger protein 2. (455 aa)
	I79_006724	DNA-binding protein SATB1. (183 aa)
	Dlx5	Homeobox protein DLX-5. (289 aa)
	Sox8	Transcription factor SOX-8. (463 aa)
	Runx2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
	Satb2	DNA-binding protein SATB. (734 aa)
	Dbx1	Homeobox protein DBX1. (335 aa)
	Bglap	Osteocalcin; Binds strongly to apatite and calcium. (99 aa)
	Neurod6	Neurogenic differentiation factor. (337 aa)
	I79_011918	Transcription factor Sox-6. (395 aa)
	I79_011919	Transcription factor SOX-6. (237 aa)
	Sp7	Transcription factor Sp7. (411 aa)
	I79_017126	T-box brain protein 1. (74 aa)
	Tbr1	T-box brain protein 1. (231 aa)
	Prrg3	Transmembrane gamma-carboxyglutamic acid protein 3. (346 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	Lhx6	LIM/homeobox protein Lhx6. (363 aa)
	I79_024048	Paired box protein Pax-3. (324 aa)
	I79_024314	Paired box protein Pax-3. (301 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bglap	Dlx5	G3HG91	G3HBM6	Osteocalcin; Binds strongly to apatite and calcium.	Homeobox protein DLX-5.	0.565
Bglap	Msx2	G3HG91	G3H1A6	Osteocalcin; Binds strongly to apatite and calcium.	Homeobox protein MSX-2.	0.556
Bglap	Runx2	G3HG91	G3HC75	Osteocalcin; Binds strongly to apatite and calcium.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.944
Bglap	Sp7	G3HG91	G3HV46	Osteocalcin; Binds strongly to apatite and calcium.	Transcription factor Sp7.	0.400
CgPICR_006170	Cux2	G3H7L8	G3H295	Fez family zinc finger protein 2.	Homeobox protein cut-like.	0.455
CgPICR_006170	I79_004750	G3H7L8	G3H3D5	Fez family zinc finger protein 2.	Transcription factor SOX-5.	0.410
CgPICR_006170	I79_017126	G3H7L8	G3I177	Fez family zinc finger protein 2.	T-box brain protein 1.	0.478
CgPICR_006170	Neurod6	G3H7L8	G3HJL3	Fez family zinc finger protein 2.	Neurogenic differentiation factor.	0.457
CgPICR_006170	Sox5	G3H7L8	G3H3D6	Fez family zinc finger protein 2.	Transcription factor SOX-5.	0.410
CgPICR_006170	Tbr1	G3H7L8	G3I178	Fez family zinc finger protein 2.	T-box brain protein 1.	0.478
Ctdspl	Neurod6	G3GVA3	G3HJL3	CTD small phosphatase-like protein.	Neurogenic differentiation factor.	0.880
Cux2	CgPICR_006170	G3H295	G3H7L8	Homeobox protein cut-like.	Fez family zinc finger protein 2.	0.455
Cux2	I79_006724	G3H295	G3H8M0	Homeobox protein cut-like.	DNA-binding protein SATB1.	0.681
Cux2	I79_024048	G3H295	G3IJL2	Homeobox protein cut-like.	Paired box protein Pax-3.	0.516
Cux2	I79_024314	G3H295	G3IKB5	Homeobox protein cut-like.	Paired box protein Pax-3.	0.516
Cux2	Satb2	G3H295	G3HDB9	Homeobox protein cut-like.	DNA-binding protein SATB.	0.681
Dbx1	Lhx6	G3HE41	G3IBT6	Homeobox protein DBX1.	LIM/homeobox protein Lhx6.	0.758
Dbx1	Tbr1	G3HE41	G3I178	Homeobox protein DBX1.	T-box brain protein 1.	0.469
Dlx1	Dlx2	G3GUB6	G3GUB7	Homeobox protein DLX-1.	Homeobox protein DLX-2.	0.841
Dlx1	Lhx6	G3GUB6	G3IBT6	Homeobox protein DLX-1.	LIM/homeobox protein Lhx6.	0.719