(14 nodes) Mixed, incl. Patched binding, and Hedgehog family protein binding network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ptch2	Protein patched-like 2. (1176 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Boc	Brother of CDO. (1070 aa)
	I79_004847	Kinesin-like protein KIF21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1603 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006961	Serine/threonine-protein kinase ULK4. (1552 aa)
	Hhip	Hedgehog-interacting protein. (671 aa)
	Cdon	Cell adhesion molecule-related/down-regulated by oncogenes. (1254 aa)
	I79_013638	Zinc finger protein GLIS3. (233 aa)
	Glis3	Zinc finger protein GLIS3. (343 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	I79_019340	Suppressor of fused-like. (144 aa)
	I79_021177	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1191 aa)
	Ptch1	Protein patched-like 1. (1114 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Boc	Cdon	G3H097	G3HFJ8	Brother of CDO.	Cell adhesion molecule-related/down-regulated by oncogenes.	0.972
Boc	Hhip	G3H097	G3H9G2	Brother of CDO.	Hedgehog-interacting protein.	0.434
Boc	I79_006225	G3H097	G3H796	Brother of CDO.	Sonic hedgehog protein.	0.914
Boc	Ihh	G3H097	G3HWF8	Brother of CDO.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.993
Boc	Ptch1	G3H097	G3IJP5	Brother of CDO.	Protein patched-like 1.	0.987
Boc	Ptch2	G3H097	G3GYR3	Brother of CDO.	Protein patched-like 2.	0.968
Boc	Smo	G3H097	G3GZ55	Brother of CDO.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.961
Cdon	Boc	G3HFJ8	G3H097	Cell adhesion molecule-related/down-regulated by oncogenes.	Brother of CDO.	0.972
Cdon	I79_006225	G3HFJ8	G3H796	Cell adhesion molecule-related/down-regulated by oncogenes.	Sonic hedgehog protein.	0.965
Cdon	Ihh	G3HFJ8	G3HWF8	Cell adhesion molecule-related/down-regulated by oncogenes.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.993
Cdon	Ptch1	G3HFJ8	G3IJP5	Cell adhesion molecule-related/down-regulated by oncogenes.	Protein patched-like 1.	0.988
Cdon	Ptch2	G3HFJ8	G3GYR3	Cell adhesion molecule-related/down-regulated by oncogenes.	Protein patched-like 2.	0.968
Cdon	Smo	G3HFJ8	G3GZ55	Cell adhesion molecule-related/down-regulated by oncogenes.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.633
Glis3	I79_004847	G3HS14	G3H3J9	Zinc finger protein GLIS3.	Kinesin-like protein KIF21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.647
Glis3	I79_013638	G3HS14	G3HS13	Zinc finger protein GLIS3.	Zinc finger protein GLIS3.	0.899
Glis3	I79_019340	G3HS14	G3I755	Zinc finger protein GLIS3.	Suppressor of fused-like.	0.719
Glis3	I79_021177	G3HS14	G3IBZ1	Zinc finger protein GLIS3.	Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.647
Glis3	Ptch1	G3HS14	G3IJP5	Zinc finger protein GLIS3.	Protein patched-like 1.	0.427
Glis3	Ptch2	G3HS14	G3GYR3	Zinc finger protein GLIS3.	Protein patched-like 2.	0.427
Glis3	Smo	G3HS14	G3GZ55	Zinc finger protein GLIS3.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.596