STRINGSTRING
I79_000157 I79_000157 Plcg2 Plcg2 I79_000473 I79_000473 I79_000474 I79_000474 Tiam1 Tiam1 I79_000883 I79_000883 CgPICR_012052 CgPICR_012052 Fgf23 Fgf23 I79_001364 I79_001364 Ntf3 Ntf3 Ptpn6 Ptpn6 Fgf17 Fgf17 Eml4 Eml4 I79_001734 I79_001734 Hgfac Hgfac I79_002099 I79_002099 I79_002104 I79_002104 Aatk Aatk Rac3 Rac3 Pik3r5 Pik3r5 I79_002696 I79_002696 Spem2 Spem2 Mdk Mdk Ptprj Ptprj I79_002944 I79_002944 I79_003177 I79_003177 Fgf20 Fgf20 Blnk Blnk I79_003820 I79_003820 Dok3 Dok3 I79_003896 I79_003896 I79_003906 I79_003906 I79_004031 I79_004031 I79_004244 I79_004244 Sh2b3 Sh2b3 Kras Kras I79_005111 I79_005111 Pik3r1 Pik3r1 I79_005331 I79_005331 Fer Fer H671_xg20512 H671_xg20512 Erbb2 Erbb2 Igf1 Igf1 Angpt4 Angpt4 Mst1r Mst1r I79_006679 I79_006679 I79_006732 I79_006732 I79_007063 I79_007063 I79_007089 I79_007089 I79_007090 I79_007090 I79_007229 I79_007229 Sh2b2 Sh2b2 Ptn Ptn Il34 Il34 I79_007693 I79_007693 I79_007744 I79_007744 Angpt2 Angpt2 Shc1 Shc1 Sh3gl1 Sh3gl1 I79_008231 I79_008231 I79_008304 I79_008304 Nrp2 Nrp2 Hck Hck Fgfrl1 Fgfrl1 I79_008941 I79_008941 Fgf1 Fgf1 Ptpn1 Ptpn1 I79_009115 I79_009115 I79_009116 I79_009116 Shc2 Shc2 Fgf22 Fgf22 Ripk4 Ripk4 I79_009314 I79_009314 Pgf Pgf Crkl Crkl I79_009585 I79_009585 I79_009586 I79_009586 I79_009691 I79_009691 Vegfc Vegfc Srms Srms I79_009958 I79_009958 Pir Pir I79_009992 I79_009992 Rasgrp1 Rasgrp1 Syk Syk Shc3 Shc3 Kitlg Kitlg Ngf Ngf Ngfr Ngfr Fgfr3 Fgfr3 Igf1r Igf1r Sh3gl2 Sh3gl2 Kl Kl Ptprz1 Ptprz1 Fyn Fyn Fgf16 Fgf16 I79_012556 I79_012556 Hgf Hgf Nras Nras Cblb Cblb Ikzf4 Ikzf4 Shc4 Shc4 I79_013659 I79_013659 I79_013660 I79_013660 Pdgfrb Pdgfrb Rras2 Rras2 Grb14 Grb14 Matk Matk Lcp2 Lcp2 Nrg1 Nrg1 I79_014451 I79_014451 I79_014637 I79_014637 Pdgfa Pdgfa I79_014973 I79_014973 Grap2 Grap2 Plcg1 Plcg1 Insr Insr Commd8 Commd8 I79_015659 I79_015659 Npm3 Npm3 Ins Ins Pdgfd Pdgfd I79_016223 I79_016223 Frs2 Frs2 Fgf21 Fgf21 Flt3lg Flt3lg Frs3 Frs3 Pik3ca Pik3ca H671_1g1070 H671_1g1070 Lyn Lyn Pdgfb Pdgfb Sh3gl3 Sh3gl3 Hras Hras Fgf3 Fgf3 Fgf4 Fgf4 Fgf19 Fgf19 CgPICR_017317 CgPICR_017317 I79_019028 I79_019028 Tgfa Tgfa Rasgrp2 Rasgrp2 I79_019149 I79_019149 Shoc2 Shoc2 Rgl2 Rgl2 Mybphl Mybphl I79_019403 I79_019403 Pik3cd Pik3cd Sh2b1 Sh2b1 I79_019517 I79_019517 Lat Lat Vegfb Vegfb Ntrk2 Ntrk2 I79_019797 I79_019797 Fgr Fgr H671_5g14804 H671_5g14804 Sos2 Sos2 I79_020316 I79_020316 Fgf7 Fgf7 I79_020924 I79_020924 I79_020968 I79_020968 I79_020969 I79_020969 I79_021125 I79_021125 Ereg Ereg Areg Areg I79_021283 I79_021283 Inppl1 Inppl1 I79_021564 I79_021564 I79_021577 I79_021577 Irs1 Irs1 I79_021789 I79_021789 I79_022034 I79_022034 I79_022271 I79_022271 I79_022484 I79_022484 Yes1 Yes1 Tec Tec Rras Rras I79_023365 I79_023365 Csf1 Csf1 Ntrk3 Ntrk3 Csk Csk I79_023594 I79_023594 I79_023828 I79_023828 Inpp5d Inpp5d Fgfr2 Fgfr2 I79_024271 I79_024271 Irs2 Irs2 Vav2 Vav2 I79_024372 I79_024372 I79_024412 I79_024412 Pdgfra Pdgfra Sh3glb2 Sh3glb2 Klb Klb Fgfbp1 Fgfbp1 Kit Kit I79_025534 I79_025534
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_000157E3 ubiquitin-protein ligase NEDD4. (1032 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
I79_000473Transmembrane protein 110. (204 aa)
I79_000474Transmembrane protein 110. (86 aa)
Tiam1T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
I79_000883Ras-specific guanine nucleotide-releasing factor 1; Belongs to the peptidase C1 family. (1632 aa)
CgPICR_012052Growth factor receptor-bound protein 2. (217 aa)
Fgf23Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
I79_001364Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
Ntf3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
Ptpn6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
Fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (350 aa)
Eml4Echinoderm microtubule-associated protein-like 4. (983 aa)
I79_001734GRB2-related adapter protein. (123 aa)
HgfacHepatocyte growth factor activator. (658 aa)
I79_002099Vascular endothelial growth factor receptor 1. (115 aa)
I79_002104FL cytokine receptor. (890 aa)
AatkSerine/threonine-protein kinase LMTK1. (1355 aa)
Rac3Ras-related C3 botulinum toxin substrate 3. (148 aa)
Pik3r5Phosphoinositide 3-kinase regulatory subunit 5. (148 aa)
I79_002696Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
Spem2Uncharacterized protein C17orf74-like; Belongs to the heparin-binding growth factors family. (979 aa)
MdkMidkine. (160 aa)
PtprjReceptor-type tyrosine-protein phosphatase eta. (1077 aa)
I79_002944Phosphatidylinositol 3-kinase regulatory subunit gamma. (460 aa)
I79_003177Platelet-derived growth factor receptor-like protein. (333 aa)
Fgf20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
BlnkB-cell linker protein. (457 aa)
I79_003820Tyrosine-protein kinase receptor. (607 aa)
Dok3Docking protein 3. (182 aa)
I79_003896Coagulation factor XII; Belongs to the peptidase S1 family. (560 aa)
I79_003906Fibroblast growth factor receptor 4. (1040 aa)
I79_004031Fibroblast growth factor receptor. (731 aa)
I79_004244Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
Sh2b3SH2B adapter protein 3. (364 aa)
KrasGTPase KRas. (155 aa)
I79_005111Phosphatidylinositol 3-kinase regulatory subunit beta. (653 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
FerTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
H671_xg20512SH3 domain-containing kinase-binding protein 1. (602 aa)
Erbb2Receptor protein-tyrosine kinase. (1256 aa)
Igf1Insulin-like growth factor I. (75 aa)
Angpt4Angiopoietin-4. (499 aa)
Mst1rMacrophage-stimulating protein receptor. (1382 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
I79_006732KH domain-containing, RNA-binding, signal transduction-associated protein 1. (195 aa)
I79_007063Hepatocyte growth factor receptor. (1222 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
I79_007229Receptor-type tyrosine-protein phosphatase O. (1056 aa)
Sh2b2SH2B adapter protein 2. (363 aa)
PtnPleiotrophin. (168 aa)
Il34Interleukin-34. (201 aa)
I79_007693Nitric oxide synthase; Produces nitric oxide (NO). (1129 aa)
I79_007744Angiopoietin-2. (188 aa)
Angpt2Angiopoietin-2. (288 aa)
Shc1SHC-transforming protein 1. (579 aa)
Sh3gl1Endophilin-A2. (368 aa)
I79_008231Proto-oncogene vav. (879 aa)
I79_008304Platelet endothelial cell adhesion molecule. (596 aa)
Nrp2Neuropilin; Belongs to the neuropilin family. (909 aa)
HckTyrosine-protein kinase. (503 aa)
Fgfrl1Fibroblast growth factor receptor-like 1. (503 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
I79_009115Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
I79_009116Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
Shc2SHC-transforming protein 2. (570 aa)
Fgf22Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (70 aa)
Ripk4Receptor-interacting serine/threonine-protein kinase 4. (723 aa)
I79_009314Tyrosine-protein kinase receptor Tie-1. (954 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
CrklCrk-like protein. (303 aa)
I79_009585Tyrosine-protein kinase receptor. (727 aa)
I79_009586Tyrosine-protein kinase receptor. (1183 aa)
I79_009691Growth factor receptor-bound protein 10. (518 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
SrmsTyrosine-protein kinase. (507 aa)
I79_009958Angiopoietin-1 receptor. (793 aa)
PirPirin; Belongs to the pirin family. (178 aa)
I79_009992Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (259 aa)
Rasgrp1RAS guanyl-releasing protein 1. (787 aa)
SykTyrosine-protein kinase. (611 aa)
Shc3SHC-transforming protein 3. (486 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
NgfBeta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
NgfrTumor necrosis factor receptor superfamily member 16. (429 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Sh3gl2Endophilin-A1. (152 aa)
KlKlotho. (900 aa)
Ptprz1Receptor-type tyrosine-protein phosphatase zeta. (2289 aa)
FynProto-oncogene tyrosine-protein kinase Fyn. (232 aa)
Fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (115 aa)
I79_012556Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
HgfHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
NrasCold shock domain-containing protein E1. (451 aa)
CblbE3 ubiquitin-protein ligase CBL-B. (984 aa)
Ikzf4Receptor protein-tyrosine kinase. (1902 aa)
Shc4SHC-transforming protein 4. (228 aa)
I79_013659Macrophage colony-stimulating factor 1 receptor. (595 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
Rras2Ras-related protein R-Ras2. (154 aa)
Grb14Growth factor receptor-bound protein 14. (466 aa)
MatkTyrosine-protein kinase. (545 aa)
Lcp2Lymphocyte cytosolic protein 2. (241 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform. (259 aa)
I79_014451Pro-neuregulin-1, membrane-bound isoform. (639 aa)
I79_014637Muscle M-line assembly protein unc-89. (338 aa)
PdgfaPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (265 aa)
I79_014973Pro-neuregulin-2, membrane-bound isoform. (386 aa)
Grap2GRB2-related adaptor protein 2. (324 aa)
Plcg1Phosphoinositide phospholipase C. (1217 aa)
InsrInsulin receptor. (114 aa)
Commd8Atrial natriuretic peptide-converting enzyme. (632 aa)
I79_015659Tyrosine-protein phosphatase non-receptor type 18. (187 aa)
Npm3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (337 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
PdgfdPlatelet-derived growth factor D. (253 aa)
I79_016223Tyrosine-protein kinase-like 7. (98 aa)
Frs2Fibroblast growth factor receptor substrate 2. (509 aa)
Fgf21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Flt3lgSL cytokine. (230 aa)
Frs3Fibroblast growth factor receptor substrate 3. (492 aa)
Pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
H671_1g1070Fibroblast growth factor 5-like protein; Belongs to the heparin-binding growth factors family. (239 aa)
LynTyrosine-protein kinase. (289 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Sh3gl3Endophilin-A3. (274 aa)
HrasGTPase HRas-like protein. (189 aa)
Fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (171 aa)
Fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (116 aa)
Fgf19Fibroblast growth factor 15; Belongs to the heparin-binding growth factors family. (115 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
I79_019028Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (437 aa)
TgfaProtransforming growth factor alpha. (211 aa)
Rasgrp2RAS guanyl-releasing protein 2. (540 aa)
I79_019149Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (132 aa)
Shoc2Leucine-rich repeat protein SHOC-2. (582 aa)
Rgl2Ral guanine nucleotide dissociation stimulator-like 2. (338 aa)
MybphlProteasome endopeptidase complex. (1190 aa)
I79_019403Ras-specific guanine nucleotide-releasing factor 2. (287 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
Sh2b1SH2B adapter protein 1. (443 aa)
I79_019517SH2B adapter protein 1. (226 aa)
LatLinker for activation of T-cells family member 1. (243 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
Ntrk2Tyrosine-protein kinase receptor. (383 aa)
I79_019797BDNF/NT-3 growth factors receptor. (192 aa)
FgrTyrosine-protein kinase. (435 aa)
H671_5g14804Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1012 aa)
Sos2Son of sevenless-like 2. (166 aa)
I79_020316Guanine nucleotide exchange factor VAV3. (604 aa)
Fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
I79_020924Serine/threonine-protein kinase LMTK3. (293 aa)
I79_020968Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (104 aa)
I79_020969Fibroblast growth factor 18. (85 aa)
I79_021125Epigen. (135 aa)
EregProepiregulin. (162 aa)
AregAmphiregulin. (230 aa)
I79_021283Angiopoietin-1. (298 aa)
Inppl1Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
I79_021564Pro-epidermal growth factor. (699 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
I79_021789NT-3 growth factor receptor. (389 aa)
I79_022034Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
I79_022271Ras-related C3 botulinum toxin substrate 2. (178 aa)
I79_022484Rap guanine nucleotide exchange factor 1. (934 aa)
Yes1Tyrosine-protein kinase. (541 aa)
TecTyrosine-protein kinase. (500 aa)
RrasRas-related protein R-Ras. (126 aa)
I79_023365Receptor-type tyrosine-protein phosphatase H. (387 aa)
Csf1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (552 aa)
Ntrk3Tyrosine-protein kinase receptor. (226 aa)
CskTyrosine-protein kinase. (450 aa)
I79_023594Atrial natriuretic peptide-converting enzyme. (271 aa)
I79_023828Ras-specific guanine nucleotide-releasing factor 2. (584 aa)
Inpp5dPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
Fgfr2Fibroblast growth factor receptor 2. (659 aa)
I79_024271NT-3 growth factor receptor. (114 aa)
Irs2Insulin receptor substrate 2. (465 aa)
Vav2Guanine nucleotide exchange factor VAV2. (453 aa)
I79_024372Guanine nucleotide exchange factor VAV2. (233 aa)
I79_024412PRAME family member 20/21. (80 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
Sh3glb2Endophilin-B2. (125 aa)
KlbBeta-klotho; Belongs to the glycosyl hydrolase 1 family. (730 aa)
Fgfbp1Fibroblast growth factor-binding protein 1. (248 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_025534Hyaluronan-binding protein 2. (234 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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