STRINGSTRING
I79_000157 I79_000157 Plcg2 Plcg2 Tiam1 Tiam1 I79_000883 I79_000883 CgPICR_012052 CgPICR_012052 Ptpn6 Ptpn6 Eml4 Eml4 Rac3 Rac3 Pik3r5 Pik3r5 I79_002696 I79_002696 I79_002944 I79_002944 Blnk Blnk Dok3 Dok3 I79_004244 I79_004244 Kras Kras I79_005111 I79_005111 Pik3r1 Pik3r1 I79_005331 I79_005331 Fer Fer Erbb2 Erbb2 Igf1 Igf1 I79_006732 I79_006732 I79_007089 I79_007089 I79_007090 I79_007090 Shc1 Shc1 I79_008231 I79_008231 I79_008304 I79_008304 Hck Hck I79_008941 I79_008941 Ptpn1 Ptpn1 I79_009115 I79_009115 I79_009116 I79_009116 Shc2 Shc2 Crkl Crkl I79_009586 I79_009586 I79_009691 I79_009691 Srms Srms Rasgrp1 Rasgrp1 Syk Syk Shc3 Shc3 Igf1r Igf1r Fyn Fyn Nras Nras Ikzf4 Ikzf4 Shc4 Shc4 Rras2 Rras2 Grb14 Grb14 Matk Matk Lcp2 Lcp2 Nrg1 Nrg1 I79_014451 I79_014451 I79_014973 I79_014973 Grap2 Grap2 Plcg1 Plcg1 Insr Insr I79_015659 I79_015659 Ins Ins Frs2 Frs2 Frs3 Frs3 Pik3ca Pik3ca Lyn Lyn Hras Hras CgPICR_017317 CgPICR_017317 I79_019028 I79_019028 Tgfa Tgfa Rasgrp2 Rasgrp2 Shoc2 Shoc2 Rgl2 Rgl2 I79_019403 I79_019403 Pik3cd Pik3cd Lat Lat Fgr Fgr H671_5g14804 H671_5g14804 Sos2 Sos2 I79_020316 I79_020316 I79_021125 I79_021125 Ereg Ereg Areg Areg Inppl1 Inppl1 I79_021564 I79_021564 Irs1 Irs1 I79_022271 I79_022271 I79_022484 I79_022484 Yes1 Yes1 Tec Tec Rras Rras Csk Csk I79_023828 I79_023828 Inpp5d Inpp5d Irs2 Irs2 Vav2 Vav2 I79_024372 I79_024372
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_000157E3 ubiquitin-protein ligase NEDD4. (1032 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
Tiam1T-lymphoma invasion and metastasis-inducing protein 1. (1591 aa)
I79_000883Ras-specific guanine nucleotide-releasing factor 1; Belongs to the peptidase C1 family. (1632 aa)
CgPICR_012052Growth factor receptor-bound protein 2. (217 aa)
Ptpn6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
Eml4Echinoderm microtubule-associated protein-like 4. (983 aa)
Rac3Ras-related C3 botulinum toxin substrate 3. (148 aa)
Pik3r5Phosphoinositide 3-kinase regulatory subunit 5. (148 aa)
I79_002696Phosphoinositide 3-kinase regulatory subunit 6. (395 aa)
I79_002944Phosphatidylinositol 3-kinase regulatory subunit gamma. (460 aa)
BlnkB-cell linker protein. (457 aa)
Dok3Docking protein 3. (182 aa)
I79_004244Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
KrasGTPase KRas. (155 aa)
I79_005111Phosphatidylinositol 3-kinase regulatory subunit beta. (653 aa)
Pik3r1Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
I79_005331Receptor tyrosine-protein kinase erbB-4. (480 aa)
FerTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
Erbb2Receptor protein-tyrosine kinase. (1256 aa)
Igf1Insulin-like growth factor I. (75 aa)
I79_006732KH domain-containing, RNA-binding, signal transduction-associated protein 1. (195 aa)
I79_007089Receptor tyrosine-protein kinase erbB-4. (225 aa)
I79_007090Receptor tyrosine-protein kinase erbB-4. (182 aa)
Shc1SHC-transforming protein 1. (579 aa)
I79_008231Proto-oncogene vav. (879 aa)
I79_008304Platelet endothelial cell adhesion molecule. (596 aa)
HckTyrosine-protein kinase. (503 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
Ptpn1Tyrosine-protein phosphatase non-receptor type 1. (335 aa)
I79_009115Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
I79_009116Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
Shc2SHC-transforming protein 2. (570 aa)
CrklCrk-like protein. (303 aa)
I79_009586Tyrosine-protein kinase receptor. (1183 aa)
I79_009691Growth factor receptor-bound protein 10. (518 aa)
SrmsTyrosine-protein kinase. (507 aa)
Rasgrp1RAS guanyl-releasing protein 1. (787 aa)
SykTyrosine-protein kinase. (611 aa)
Shc3SHC-transforming protein 3. (486 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
FynProto-oncogene tyrosine-protein kinase Fyn. (232 aa)
NrasCold shock domain-containing protein E1. (451 aa)
Ikzf4Receptor protein-tyrosine kinase. (1902 aa)
Shc4SHC-transforming protein 4. (228 aa)
Rras2Ras-related protein R-Ras2. (154 aa)
Grb14Growth factor receptor-bound protein 14. (466 aa)
MatkTyrosine-protein kinase. (545 aa)
Lcp2Lymphocyte cytosolic protein 2. (241 aa)
Nrg1Pro-neuregulin-1, membrane-bound isoform. (259 aa)
I79_014451Pro-neuregulin-1, membrane-bound isoform. (639 aa)
I79_014973Pro-neuregulin-2, membrane-bound isoform. (386 aa)
Grap2GRB2-related adaptor protein 2. (324 aa)
Plcg1Phosphoinositide phospholipase C. (1217 aa)
InsrInsulin receptor. (114 aa)
I79_015659Tyrosine-protein phosphatase non-receptor type 18. (187 aa)
InsMultifunctional fusion protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; Belongs to the ferritin family. (248 aa)
Frs2Fibroblast growth factor receptor substrate 2. (509 aa)
Frs3Fibroblast growth factor receptor substrate 3. (492 aa)
Pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
LynTyrosine-protein kinase. (289 aa)
HrasGTPase HRas-like protein. (189 aa)
CgPICR_017317Insulin receptor substrate 1. (493 aa)
I79_019028Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (437 aa)
TgfaProtransforming growth factor alpha. (211 aa)
Rasgrp2RAS guanyl-releasing protein 2. (540 aa)
Shoc2Leucine-rich repeat protein SHOC-2. (582 aa)
Rgl2Ral guanine nucleotide dissociation stimulator-like 2. (338 aa)
I79_019403Ras-specific guanine nucleotide-releasing factor 2. (287 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
LatLinker for activation of T-cells family member 1. (243 aa)
FgrTyrosine-protein kinase. (435 aa)
H671_5g14804Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1012 aa)
Sos2Son of sevenless-like 2. (166 aa)
I79_020316Guanine nucleotide exchange factor VAV3. (604 aa)
I79_021125Epigen. (135 aa)
EregProepiregulin. (162 aa)
AregAmphiregulin. (230 aa)
Inppl1Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
I79_021564Pro-epidermal growth factor. (699 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
I79_022271Ras-related C3 botulinum toxin substrate 2. (178 aa)
I79_022484Rap guanine nucleotide exchange factor 1. (934 aa)
Yes1Tyrosine-protein kinase. (541 aa)
TecTyrosine-protein kinase. (500 aa)
RrasRas-related protein R-Ras. (126 aa)
CskTyrosine-protein kinase. (450 aa)
I79_023828Ras-specific guanine nucleotide-releasing factor 2. (584 aa)
Inpp5dPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
Irs2Insulin receptor substrate 2. (465 aa)
Vav2Guanine nucleotide exchange factor VAV2. (453 aa)
I79_024372Guanine nucleotide exchange factor VAV2. (233 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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