(23 nodes) GPVI-mediated activation cascade, and SH2 adaptor protein C, SH2 domain network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	Plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
	Ptpn6	Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
	Blnk	B-cell linker protein. (457 aa)
	I79_004244	Tyrosine-protein phosphatase non-receptor type 11. (583 aa)
	I79_008231	Proto-oncogene vav. (879 aa)
	I79_008304	Platelet endothelial cell adhesion molecule. (596 aa)
	Hck	Tyrosine-protein kinase. (503 aa)
	Shc2	SHC-transforming protein 2. (570 aa)
	Syk	Tyrosine-protein kinase. (611 aa)
	Fyn	Proto-oncogene tyrosine-protein kinase Fyn. (232 aa)
	Shc4	SHC-transforming protein 4. (228 aa)
	Lcp2	Lymphocyte cytosolic protein 2. (241 aa)
	Grap2	GRB2-related adaptor protein 2. (324 aa)
	Plcg1	Phosphoinositide phospholipase C. (1217 aa)
	Lyn	Tyrosine-protein kinase. (289 aa)
	Lat	Linker for activation of T-cells family member 1. (243 aa)
	Fgr	Tyrosine-protein kinase. (435 aa)
	Inppl1	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2. (1253 aa)
	I79_022271	Ras-related C3 botulinum toxin substrate 2. (178 aa)
	Tec	Tyrosine-protein kinase. (500 aa)
	Inpp5d	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1. (91 aa)
	Vav2	Guanine nucleotide exchange factor VAV2. (453 aa)
	I79_024372	Guanine nucleotide exchange factor VAV2. (233 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Blnk	Fgr	G3GZU4	G3I8T0	B-cell linker protein.	Tyrosine-protein kinase.	0.401
Blnk	Grap2	G3GZU4	G3HVZ8	B-cell linker protein.	GRB2-related adaptor protein 2.	0.497
Blnk	Hck	G3GZU4	G3HE98	B-cell linker protein.	Tyrosine-protein kinase.	0.402
Blnk	I79_008231	G3GZU4	G3HCM0	B-cell linker protein.	Proto-oncogene vav.	0.759
Blnk	Lat	G3GZU4	G3I7M9	B-cell linker protein.	Linker for activation of T-cells family member 1.	0.589
Blnk	Lcp2	G3GZU4	G3HTI0	B-cell linker protein.	Lymphocyte cytosolic protein 2.	0.953
Blnk	Lyn	G3GZU4	G3I2D1	B-cell linker protein.	Tyrosine-protein kinase.	0.961
Blnk	Plcg1	G3GZU4	G3HWN7	B-cell linker protein.	Phosphoinositide phospholipase C.	0.639
Blnk	Plcg2	G3GZU4	G3GRN8	B-cell linker protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.979
Blnk	Syk	G3GZU4	G3HIA4	B-cell linker protein.	Tyrosine-protein kinase.	0.982
Blnk	Tec	G3GZU4	G3IG50	B-cell linker protein.	Tyrosine-protein kinase.	0.927
Blnk	Vav2	G3GZU4	G3IKG8	B-cell linker protein.	Guanine nucleotide exchange factor VAV2.	0.933
Fgr	Blnk	G3I8T0	G3GZU4	Tyrosine-protein kinase.	B-cell linker protein.	0.401
Fgr	Grap2	G3I8T0	G3HVZ8	Tyrosine-protein kinase.	GRB2-related adaptor protein 2.	0.538
Fgr	Hck	G3I8T0	G3HE98	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.573
Fgr	I79_004244	G3I8T0	G3H277	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type 11.	0.578
Fgr	I79_008231	G3I8T0	G3HCM0	Tyrosine-protein kinase.	Proto-oncogene vav.	0.444
Fgr	I79_008304	G3I8T0	G3HCT8	Tyrosine-protein kinase.	Platelet endothelial cell adhesion molecule.	0.470
Fgr	Inppl1	G3I8T0	G3ICV1	Tyrosine-protein kinase.	Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2.	0.509
Fgr	Lcp2	G3I8T0	G3HTI0	Tyrosine-protein kinase.	Lymphocyte cytosolic protein 2.	0.609