STRINGSTRING
I79_002099 I79_002099 Nrp2 Nrp2 Pgf Pgf Vegfc Vegfc I79_009992 I79_009992 Kitlg Kitlg I79_012556 I79_012556 I79_013660 I79_013660 Pdgfrb Pdgfrb Pdgfa Pdgfa Pdgfd Pdgfd Pdgfb Pdgfb Vegfb Vegfb I79_022034 I79_022034 Pdgfra Pdgfra Kit Kit
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_002099Vascular endothelial growth factor receptor 1. (115 aa)
Nrp2Neuropilin; Belongs to the neuropilin family. (909 aa)
PgfPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (154 aa)
VegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (346 aa)
I79_009992Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (259 aa)
KitlgKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
I79_012556Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1227 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
PdgfaPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (265 aa)
PdgfdPlatelet-derived growth factor D. (253 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
VegfbVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (150 aa)
I79_022034Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
PdgfraPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1082 aa)
KitMast/stem cell growth factor receptor. (452 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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