(41 nodes) Interleukin-21 signaling, and JAK-STAT signaling pathway network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Il15ra	Interleukin-15 receptor subunit alpha-like protein. (264 aa)
	I79_000819	Interferon-alpha/beta receptor beta chain. (253 aa)
	I79_000823	Interferon-alpha/beta receptor beta chain. (256 aa)
	I79_000824	Interleukin-10 receptor beta chain. (349 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	Ifngr2	Interferon-gamma receptor beta chain. (332 aa)
	Ifngr1	Interferon-gamma receptor alpha chain. (471 aa)
	Socs1	Suppressor of cytokine signaling 1. (93 aa)
	Ifnb1	Interferon beta. (182 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	I79_005129	Tyrosine-protein kinase JAK3. (330 aa)
	Jak3	Tyrosine-protein kinase JAK3. (222 aa)
	Tyk2	Tyrosine-protein kinase. (1182 aa)
	Cish	Cytokine-inducible SH2-containing protein. (224 aa)
	Il10	Interleukin-10. (178 aa)
	Irf9	Interferon regulatory factor 9. (398 aa)
	Il15	Interleukin; Belongs to the IL-15/IL-21 family. (155 aa)
	I79_011181	Interleukin-7 receptor subunit alpha. (257 aa)
	I79_011711	Signal transducer and activator of transcription 5B. (274 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Il22ra1	Interleukin-22 receptor subunit alpha-1. (582 aa)
	I79_012613	OTU domain-containing protein 4. (152 aa)
	Ppp1r13l	RelA-associated inhibitor. (183 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Il21	Interleukin-21. (67 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	Jak1	Tyrosine-protein kinase. (1140 aa)
	I79_016869	Interferon alpha-12. (190 aa)
	Ifne	Interferon epsilon. (192 aa)
	Il4r	Interleukin-4 receptor alpha chain. (835 aa)
	Il21r	Interleukin-21 receptor. (535 aa)
	CUNHXorf65	Cytokine receptor common gamma chain. (456 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_020202	Signal transducer and activator of transcription 4. (237 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	I79_024226	Interleukin-10 receptor alpha chain. (164 aa)
	Il10ra	Interleukin-10 receptor alpha chain. (353 aa)
	I79_025584	Interleukin-2 receptor subunit beta. (202 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUNHXorf65	I79_005129	G3I7K3	G3H4C8	Cytokine receptor common gamma chain.	Tyrosine-protein kinase JAK3.	0.838
CUNHXorf65	I79_011181	G3I7K3	G3HKG1	Cytokine receptor common gamma chain.	Interleukin-7 receptor subunit alpha.	0.850
CUNHXorf65	I79_011711	G3I7K3	G3HLW7	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription 5B.	0.464
CUNHXorf65	I79_011712	G3I7K3	G3HLW8	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription.	0.464
CUNHXorf65	I79_020202	G3I7K3	G3I9G0	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription 4.	0.423
CUNHXorf65	I79_025584	G3I7K3	G3INQ3	Cytokine receptor common gamma chain.	Interleukin-2 receptor subunit beta.	0.986
CUNHXorf65	IL2	G3I7K3	G3HTL8	Cytokine receptor common gamma chain.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.958
CUNHXorf65	Il10	G3I7K3	G3HB01	Cytokine receptor common gamma chain.	Interleukin-10.	0.405
CUNHXorf65	Il15	G3I7K3	G3HJ60	Cytokine receptor common gamma chain.	Interleukin; Belongs to the IL-15/IL-21 family.	0.966
CUNHXorf65	Il15ra	G3I7K3	G3GR70	Cytokine receptor common gamma chain.	Interleukin-15 receptor subunit alpha-like protein.	0.942
CUNHXorf65	Il21	G3I7K3	G3HTL7	Cytokine receptor common gamma chain.	Interleukin-21.	0.785
CUNHXorf65	Il21r	G3I7K3	G3I4F3	Cytokine receptor common gamma chain.	Interleukin-21 receptor.	0.766
CUNHXorf65	Il4r	G3I7K3	G3I4F2	Cytokine receptor common gamma chain.	Interleukin-4 receptor alpha chain.	0.760
CUNHXorf65	Jak1	G3I7K3	G3HY52	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.869
CUNHXorf65	Jak2	G3I7K3	G3IEQ4	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.766
CUNHXorf65	Jak3	G3I7K3	G3H4C9	Cytokine receptor common gamma chain.	Tyrosine-protein kinase JAK3.	0.838
CUNHXorf65	Stat1	G3I7K3	G3I9F9	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription.	0.491
CUNHXorf65	Stat3	G3I7K3	G3HLW9	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription.	0.610
CUNHXorf65	Stat6	G3I7K3	G3HW32	Cytokine receptor common gamma chain.	Signal transducer and activator of transcription.	0.488
CUNHXorf65	Tyk2	G3I7K3	G3H6C9	Cytokine receptor common gamma chain.	Tyrosine-protein kinase.	0.727