(27 nodes) Interleukin-20 family signaling, and Regulation of IFNG signaling network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	I79_000823	Interferon-alpha/beta receptor beta chain. (256 aa)
	I79_000824	Interleukin-10 receptor beta chain. (349 aa)
	Ifnar1	Interferon-alpha/beta receptor alpha chain. (483 aa)
	Ifngr2	Interferon-gamma receptor beta chain. (332 aa)
	Ifngr1	Interferon-gamma receptor alpha chain. (471 aa)
	Socs1	Suppressor of cytokine signaling 1. (93 aa)
	Ifnb1	Interferon beta. (182 aa)
	Ifng	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (157 aa)
	Socs3	Suppressor of cytokine signaling 3. (225 aa)
	Jak3	Tyrosine-protein kinase JAK3. (222 aa)
	Tyk2	Tyrosine-protein kinase. (1182 aa)
	Cish	Cytokine-inducible SH2-containing protein. (224 aa)
	Il10	Interleukin-10. (178 aa)
	Irf9	Interferon regulatory factor 9. (398 aa)
	I79_011711	Signal transducer and activator of transcription 5B. (274 aa)
	I79_011712	Signal transducer and activator of transcription. (793 aa)
	Stat3	Signal transducer and activator of transcription. (770 aa)
	Il22ra1	Interleukin-22 receptor subunit alpha-1. (582 aa)
	Stat2	Signal transducer and activator of transcription. (806 aa)
	Stat6	Signal transducer and activator of transcription. (844 aa)
	Jak1	Tyrosine-protein kinase. (1140 aa)
	Il4r	Interleukin-4 receptor alpha chain. (835 aa)
	Stat1	Signal transducer and activator of transcription. (749 aa)
	I79_020202	Signal transducer and activator of transcription 4. (237 aa)
	Jak2	Tyrosine-protein kinase. (1122 aa)
	I79_024226	Interleukin-10 receptor alpha chain. (164 aa)
	Il10ra	Interleukin-10 receptor alpha chain. (353 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cish	I79_011711	G3H8B2	G3HLW7	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription 5B.	0.942
Cish	I79_011712	G3H8B2	G3HLW8	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.945
Cish	I79_020202	G3H8B2	G3I9G0	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription 4.	0.403
Cish	Ifng	G3H8B2	G3GY20	Cytokine-inducible SH2-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.588
Cish	Il10	G3H8B2	G3HB01	Cytokine-inducible SH2-containing protein.	Interleukin-10.	0.403
Cish	Il4r	G3H8B2	G3I4F2	Cytokine-inducible SH2-containing protein.	Interleukin-4 receptor alpha chain.	0.637
Cish	Jak1	G3H8B2	G3HY52	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.611
Cish	Jak2	G3H8B2	G3IEQ4	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.686
Cish	Jak3	G3H8B2	G3H4C9	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase JAK3.	0.456
Cish	Socs3	G3H8B2	G3H3F1	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 3.	0.437
Cish	Stat1	G3H8B2	G3I9F9	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.955
Cish	Stat2	G3H8B2	G3HRN9	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.948
Cish	Stat3	G3H8B2	G3HLW9	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.959
Cish	Stat6	G3H8B2	G3HW32	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.947
Cish	Tyk2	G3H8B2	G3H6C9	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.614
I79_000823	I79_000824	G3GT49	G3GT50	Interferon-alpha/beta receptor beta chain.	Interleukin-10 receptor beta chain.	0.728
I79_000823	I79_011711	G3GT49	G3HLW7	Interferon-alpha/beta receptor beta chain.	Signal transducer and activator of transcription 5B.	0.498
I79_000823	I79_011712	G3GT49	G3HLW8	Interferon-alpha/beta receptor beta chain.	Signal transducer and activator of transcription.	0.498
I79_000823	I79_020202	G3GT49	G3I9G0	Interferon-alpha/beta receptor beta chain.	Signal transducer and activator of transcription 4.	0.622
I79_000823	Ifnar1	G3GT49	G3GT51	Interferon-alpha/beta receptor beta chain.	Interferon-alpha/beta receptor alpha chain.	0.991