(5 nodes) Response to melanocyte-stimulating hormone, and Agouti network (Cricetulus griseus)

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Your Input:
	I79_002536	Pro-opiomelanocortin. (159 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Mc4r	Melanocortin receptor 4. (332 aa)
	I79_015980	Leptin receptor. (533 aa)
	CgPICR_005625	Agouti-related protein. (131 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CgPICR_005625	I79_002536	G3HZM4	G3GXP4	Agouti-related protein.	Pro-opiomelanocortin.	0.955
CgPICR_005625	I79_015980	G3HZM4	G3HY62	Agouti-related protein.	Leptin receptor.	0.776
CgPICR_005625	Lep	G3HZM4	G3GZ86	Agouti-related protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.942
CgPICR_005625	Mc4r	G3HZM4	G3HMW1	Agouti-related protein.	Melanocortin receptor 4.	0.982
I79_002536	CgPICR_005625	G3GXP4	G3HZM4	Pro-opiomelanocortin.	Agouti-related protein.	0.955
I79_002536	I79_015980	G3GXP4	G3HY62	Pro-opiomelanocortin.	Leptin receptor.	0.846
I79_002536	Lep	G3GXP4	G3GZ86	Pro-opiomelanocortin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.929
I79_002536	Mc4r	G3GXP4	G3HMW1	Pro-opiomelanocortin.	Melanocortin receptor 4.	0.991
I79_015980	CgPICR_005625	G3HY62	G3HZM4	Leptin receptor.	Agouti-related protein.	0.776
I79_015980	I79_002536	G3HY62	G3GXP4	Leptin receptor.	Pro-opiomelanocortin.	0.846
I79_015980	Lep	G3HY62	G3GZ86	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.992
I79_015980	Mc4r	G3HY62	G3HMW1	Leptin receptor.	Melanocortin receptor 4.	0.753
Lep	CgPICR_005625	G3GZ86	G3HZM4	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Agouti-related protein.	0.942
Lep	I79_002536	G3GZ86	G3GXP4	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Pro-opiomelanocortin.	0.929
Lep	I79_015980	G3GZ86	G3HY62	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Leptin receptor.	0.992
Lep	Mc4r	G3GZ86	G3HMW1	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Melanocortin receptor 4.	0.897
Mc4r	CgPICR_005625	G3HMW1	G3HZM4	Melanocortin receptor 4.	Agouti-related protein.	0.982
Mc4r	I79_002536	G3HMW1	G3GXP4	Melanocortin receptor 4.	Pro-opiomelanocortin.	0.991
Mc4r	I79_015980	G3HMW1	G3HY62	Melanocortin receptor 4.	Leptin receptor.	0.753
Mc4r	Lep	G3HMW1	G3GZ86	Melanocortin receptor 4.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.897