(11 nodes) Mixed, incl. SCF-beta-TrCP mediated degradation of Emi1, and Polo kinase kinase network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fbxo28	F-box only protein 28. (275 aa)
	Fbxo5	F-box only protein 5. (388 aa)
	Cul1	Cullin-1; Belongs to the cullin family. (776 aa)
	Fbxo11	F-box only protein 11. (843 aa)
	Fbxw11	Serine/threonine-protein kinase 10. (1359 aa)
	Fbxo4	F-box only protein 4. (248 aa)
	Fbxo43	F-box only protein 43. (1330 aa)
	Fbxo2	F-box only protein 2. (332 aa)
	Rbx1	40S ribosomal protein S2. (185 aa)
	Btrc	F-box/WD repeat-containing protein 1A. (488 aa)
	Fbxo9	F-box only protein 9. (366 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Btrc	Cul1	G3I574	G3GXG0	F-box/WD repeat-containing protein 1A.	Cullin-1; Belongs to the cullin family.	0.999
Btrc	Fbxo2	G3I574	G3HUL8	F-box/WD repeat-containing protein 1A.	F-box only protein 2.	0.945
Btrc	Fbxo4	G3I574	G3HHE8	F-box/WD repeat-containing protein 1A.	F-box only protein 4.	0.915
Btrc	Fbxo43	G3I574	G3HU71	F-box/WD repeat-containing protein 1A.	F-box only protein 43.	0.910
Btrc	Fbxo5	G3I574	G3GU27	F-box/WD repeat-containing protein 1A.	F-box only protein 5.	0.910
Btrc	Fbxw11	G3I574	G3H9P3	F-box/WD repeat-containing protein 1A.	Serine/threonine-protein kinase 10.	0.901
Btrc	Rbx1	G3I574	G3I535	F-box/WD repeat-containing protein 1A.	40S ribosomal protein S2.	0.900
Cul1	Btrc	G3GXG0	G3I574	Cullin-1; Belongs to the cullin family.	F-box/WD repeat-containing protein 1A.	0.999
Cul1	Fbxo11	G3GXG0	G3H5Q6	Cullin-1; Belongs to the cullin family.	F-box only protein 11.	0.933
Cul1	Fbxo2	G3GXG0	G3HUL8	Cullin-1; Belongs to the cullin family.	F-box only protein 2.	0.906
Cul1	Fbxo28	G3GXG0	G3GRA9	Cullin-1; Belongs to the cullin family.	F-box only protein 28.	0.460
Cul1	Fbxo4	G3GXG0	G3HHE8	Cullin-1; Belongs to the cullin family.	F-box only protein 4.	0.907
Cul1	Fbxo43	G3GXG0	G3HU71	Cullin-1; Belongs to the cullin family.	F-box only protein 43.	0.932
Cul1	Fbxo5	G3GXG0	G3GU27	Cullin-1; Belongs to the cullin family.	F-box only protein 5.	0.932
Cul1	Fbxo9	G3GXG0	G3I5G9	Cullin-1; Belongs to the cullin family.	F-box only protein 9.	0.909
Cul1	Fbxw11	G3GXG0	G3H9P3	Cullin-1; Belongs to the cullin family.	Serine/threonine-protein kinase 10.	0.906
Cul1	Rbx1	G3GXG0	G3I535	Cullin-1; Belongs to the cullin family.	40S ribosomal protein S2.	0.902
Fbxo11	Cul1	G3H5Q6	G3GXG0	F-box only protein 11.	Cullin-1; Belongs to the cullin family.	0.933
Fbxo11	Fbxo2	G3H5Q6	G3HUL8	F-box only protein 11.	F-box only protein 2.	0.420
Fbxo11	Fbxo28	G3H5Q6	G3GRA9	F-box only protein 11.	F-box only protein 28.	0.876