STRINGSTRING
I79_010194 I79_010194 I79_008252 I79_008252 Clic5 Clic5 Cntn2 Cntn2 I79_016547 I79_016547 Ppargc1a Ppargc1a I79_015169 I79_015169 PPARG PPARG Slc25a25 Slc25a25 I79_014549 I79_014549 Apoe Apoe I79_012267 I79_012267 Mc4r Mc4r Sgip1 Sgip1 I79_010474 I79_010474 Trpv4 Trpv4 Guca2b Guca2b Sorl1 Sorl1 I79_024850 I79_024850 I79_023937 I79_023937 Adrb2 Adrb2 Prlh Prlh Cckar Cckar Rmi1 Rmi1 Enpp1 Enpp1 I79_020576 I79_020576 I79_019878 I79_019878 I79_018445 I79_018445 Sct Sct Gdf3 Gdf3 Mapk14 Mapk14 Rasal2 Rasal2 I79_000117 I79_000117 I79_000977 I79_000977 Lep Lep Gpr39 Gpr39 I79_003212 I79_003212 I79_005100 I79_005100 Nmur2 Nmur2 I79_005524 I79_005524
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_010194Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (387 aa)
I79_008252Guanylate cyclase activator 2B. (104 aa)
Clic5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (236 aa)
Cntn2Contactin-2. (1008 aa)
I79_016547DCC-interacting protein 13-beta. (634 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
I79_015169Ras GTPase-activating protein nGAP. (1105 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Slc25a25Calcium-binding mitochondrial carrier protein SCaMC-2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (65 aa)
I79_014549STE20/SPS1-related proline-alanine-rich protein kinase. (418 aa)
ApoeApolipoprotein E. (313 aa)
I79_012267ProSAAS. (175 aa)
Mc4rMelanocortin receptor 4. (332 aa)
Sgip1SH3-containing GRB2-like protein 3-interacting protein 1; Belongs to the adaptor complexes medium subunit family. (275 aa)
I79_010474Solute carrier family 12 member 3. (995 aa)
Trpv4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
Guca2bGuanylate cyclase activator 2B. (107 aa)
Sorl1Sortilin-related receptor. (223 aa)
I79_024850Patatin-like phospholipase domain-containing protein 3. (273 aa)
I79_023937Sortilin-related receptor. (88 aa)
Adrb2Beta-2 adrenergic receptor. (337 aa)
PrlhProlactin-releasing peptide. (87 aa)
CckarCholecystokinin receptor type A. (205 aa)
Rmi1RecQ-mediated genome instability protein 1. (618 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
I79_020576Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (267 aa)
I79_019878Sortilin. (1038 aa)
I79_018445F-box-like/WD repeat-containing protein TBL1XR1. (429 aa)
SctSecretin-like protein. (132 aa)
Gdf3Growth/differentiation factor 3. (361 aa)
Mapk14Mitogen-activated protein kinase. (349 aa)
Rasal2Ras GTPase-activating protein SynGAP. (161 aa)
I79_000117GDNF family receptor alpha-like. (388 aa)
I79_000977Metalloendopeptidase OMA1, mitochondrial. (238 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Gpr39G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (289 aa)
I79_003212G-protein coupled receptor 39. (151 aa)
I79_005100Growth/differentiation factor 15. (96 aa)
Nmur2Neuromedin-U receptor 2; Belongs to the G-protein coupled receptor 1 family. (291 aa)
I79_005524Secretin receptor; Belongs to the G-protein coupled receptor 2 family. (443 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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