STRINGSTRING
I79_011711 I79_011711 Hspd1 Hspd1 I79_011202 I79_011202 Nsd2 Nsd2 Lamp1 Lamp1 Hmces Hmces Rasgrp1 Rasgrp1 I79_009344 I79_009344 I79_008828 I79_008828 IL12B IL12B I79_008231 I79_008231 C3 C3 Ticam1 Ticam1 Rsad2 Rsad2 I79_007699 I79_007699 I79_016618 I79_016618 Ap1g1 Ap1g1 Zp3 Zp3 Itgb2 Itgb2 Cd40 Cd40 I79_006232 I79_006232 Ddx50 Ddx50 Ddx21 Ddx21 Il1r1 Il1r1 Il18rap Il18rap Tbx21 Tbx21 Msh2 Msh2 Nod2 Nod2 Fbxo38 Fbxo38 Zbtb1 Zbtb1 I79_004904 I79_004904 F2rl1 F2rl1 I79_004486 I79_004486 Il18 Il18 I79_004285 I79_004285 Ptafr Ptafr Arid5a Arid5a I79_003972 I79_003972 Tp53bp1 Tp53bp1 B2m B2m I79_003362 I79_003362 Tnfsf4 Tnfsf4 Traf6 Traf6 Cd28 Cd28 I79_002750 I79_002750 I79_001405 I79_001405 CgPICR_003438 CgPICR_003438 Atad5 Atad5 I79_000697 I79_000697 Tfrc Tfrc Shld1 Shld1 Plcg2 Plcg2 Gata3 Gata3 H671_3g9603 H671_3g9603 I79_017371 I79_017371 I79_017397 I79_017397 I79_017398 I79_017398 Clcf1 Clcf1 Cxcl1 Cxcl1 Pagr1 Pagr1 I79_019042 I79_019042 Stx4 Stx4 CgPICR_017737 CgPICR_017737 I79_019913 I79_019913 Tgfb1 Tgfb1 Stx7 Stx7 I79_021848 I79_021848 I79_021870 I79_021870 I79_022023 I79_022023 I79_022300 I79_022300 Jhy Jhy Traf2 Traf2 Kmt5b Kmt5b I79_024407 I79_024407 I79_024443 I79_024443 I79_024694 I79_024694 Kit Kit I79_025514 I79_025514 Hpx Hpx Paxip1 Paxip1 I79_025915 I79_025915 Lta Lta Tnf Tnf I79_016106 I79_016106 Cd81 Cd81 Dhx36 Dhx36 Stat6 Stat6 I79_015109 I79_015109 Mad2l2 Mad2l2 Fzd5 Fzd5 IL2 IL2 Il21 Il21 Mlh1 Mlh1 Il23a Il23a Ddx58 Ddx58 Spata46 Spata46 Fadd Fadd I79_012636 I79_012636 I79_012384 I79_012384 Foxp3 Foxp3 Exosc3 Exosc3 Dennd1b Dennd1b I79_011712 I79_011712 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
Hspd160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (526 aa)
I79_011202T-cell surface glycoprotein CD1d1. (111 aa)
Nsd2Putative histone-lysine N-methyltransferase NSD2. (1344 aa)
Lamp1Lysosome-associated membrane glycoprotein 1. (370 aa)
HmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
Rasgrp1RAS guanyl-releasing protein 1. (787 aa)
I79_009344ATP-dependent RNA helicase DDX1. (584 aa)
I79_008828Lymphotactin. (114 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
I79_008231Proto-oncogene vav. (879 aa)
C3Complement C3. (1626 aa)
Ticam1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
Rsad2Radical S-adenosyl methionine domain-containing protein 2. (361 aa)
I79_007699GTPase IMAP family member 5. (344 aa)
I79_016618Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (470 aa)
Ap1g1AP-1 complex subunit gamma. (822 aa)
Zp3Zona pellucida sperm-binding protein 3. (403 aa)
Itgb2Integrin beta. (769 aa)
Cd40Tumor necrosis factor receptor superfamily member 5. (118 aa)
I79_006232PAX-interacting protein 1. (79 aa)
Ddx50ATP-dependent RNA helicase DDX50. (670 aa)
Ddx21Nucleolar RNA helicase 2. (729 aa)
Il1r1Interleukin-1 receptor type I. (572 aa)
Il18rapInterleukin-18 receptor accessory protein. (431 aa)
Tbx21T-box transcription factor TBX21. (365 aa)
Msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (852 aa)
Nod2Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
Fbxo38F-box only protein 38. (586 aa)
Zbtb1Zinc finger and BTB domain-containing protein 1. (713 aa)
I79_004904NKG2D ligand 4. (293 aa)
F2rl1Proteinase-activated receptor 2. (374 aa)
I79_004486CD160 antigen. (151 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
I79_004285p2X purinoceptor 7. (805 aa)
PtafrPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (341 aa)
Arid5aAT-rich interactive domain-containing protein 5A. (588 aa)
I79_00397260 kDa heat shock protein, mitochondrial; Belongs to the TCP-1 chaperonin family. (104 aa)
Tp53bp1Tumor suppressor p53-binding protein 1. (1952 aa)
B2mBeta-2-microglobulin. (54 aa)
I79_003362Complement decay-accelerating factor. (157 aa)
Tnfsf4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (185 aa)
Traf6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
Cd28T-cell-specific surface glycoprotein CD28. (100 aa)
I79_002750Tumor necrosis factor ligand superfamily member 13; Belongs to the tumor necrosis factor family. (73 aa)
I79_001405Lymphocyte activation gene 3 protein. (345 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
Atad5ATPase family AAA domain-containing protein 5. (1335 aa)
I79_000697Mitogen-activated protein kinase kinase kinase 7. (287 aa)
TfrcTransferrin receptor protein 1. (757 aa)
Shld1Uncharacterized protein C20orf196-like. (208 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1199 aa)
Gata3Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
H671_3g960360 kDa heat shock protein, mitochondrial. (141 aa)
I79_017371NKG2-A/NKG2-B type II integral membrane protein. (100 aa)
I79_017397Protein kinase C zeta type. (280 aa)
I79_017398Protein kinase C zeta type. (53 aa)
Clcf1Cardiotrophin-like cytokine factor 1. (225 aa)
Cxcl1C-X-C motif chemokine. (101 aa)
Pagr1PAXIP1-associated protein 1. (251 aa)
I79_01904260 kDa heat shock protein, mitochondrial. (169 aa)
Stx4Syntaxin-4; Belongs to the syntaxin family. (298 aa)
CgPICR_017737Lysosome-associated membrane glycoprotein 1. (403 aa)
I79_019913Cell adhesion molecule 1. (390 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Stx7Syntaxin-7; Belongs to the syntaxin family. (261 aa)
I79_021848Telomere-associated protein RIF1. (1602 aa)
I79_021870CD177 antigen. (106 aa)
I79_022023Arginase-1; Belongs to the arginase family. (281 aa)
I79_02230060 kDa heat shock protein, mitochondrial. (252 aa)
JhyCytotoxic and regulatory T-cell molecule. (334 aa)
Traf2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Kmt5bHistone-lysine N-methyltransferase SUV420H1. (451 aa)
I79_02440760 kDa heat shock protein, mitochondrial. (214 aa)
I79_024443CD177 antigen. (158 aa)
I79_024694Ig-like domain-containing protein; Belongs to the MHC class II family. (208 aa)
KitMast/stem cell growth factor receptor. (452 aa)
I79_025514NKG2D ligand 1. (218 aa)
HpxHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (461 aa)
Paxip1PAX-interacting protein 1. (91 aa)
I79_025915Protein FAM49B. (58 aa)
LtaLymphotoxin-alpha; Belongs to the tumor necrosis factor family. (202 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
I79_016106Histone-lysine N-methyltransferase SUV420H2. (225 aa)
Cd81Tetraspanin. (236 aa)
Dhx36Putative ATP-dependent RNA helicase DHX36. (922 aa)
Stat6Signal transducer and activator of transcription. (844 aa)
I79_015109Interleukin-6. (174 aa)
Mad2l2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
Fzd5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (616 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
Il21Interleukin-21. (67 aa)
Mlh1DNA mismatch repair protein Mlh1-like protein. (720 aa)
Il23aInterleukin-23 subunit alpha. (196 aa)
Ddx58Putative ATP-dependent RNA helicase DDX58. (171 aa)
Spata46Uncharacterized protein C1orf111-like. (290 aa)
FaddFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
I79_012636Poliovirus receptor. (346 aa)
I79_012384Leukocyte common antigen. (962 aa)
Foxp3Forkhead box protein P3. (428 aa)
Exosc3Exosome complex exonuclease RRP40. (102 aa)
Dennd1bDENN domain-containing protein 1A. (413 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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