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Eif4e Eif4e Efhd1 Efhd1 I79_020539 I79_020539 Ramac Ramac AGO2 AGO2 Eif4e1b Eif4e1b Ncbp2 Ncbp2 I79_006282 I79_006282 I79_012168 I79_012168 Rnmt Rnmt I79_014098 I79_014098
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Eif4eEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
Efhd1Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (364 aa)
I79_020539Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (117 aa)
RamacProtein FAM103A1. (118 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (813 aa)
Eif4e1bEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (263 aa)
Ncbp2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
I79_006282Nuclear cap-binding protein subunit 1. (581 aa)
I79_012168Fragile X mental retardation 1 protein. (560 aa)
RnmtmRNA cap guanine-N7 methyltransferase. (446 aa)
I79_014098Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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