(19 nodes) Membrane protein ectodomain proteolysis network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_023145	Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1948 aa)
	I79_000010	Protein kinase C. (566 aa)
	Adam10	Disintegrin and metalloproteinase domain-containing protein 10. (675 aa)
	I79_004035	Disintegrin and metalloproteinase domain-containing protein 9. (1196 aa)
	I79_004285	p2X purinoceptor 7. (805 aa)
	Aph1a	Gamma-secretase subunit APH-1A. (247 aa)
	I79_005385	Gamma-secretase subunit APH-1B. (219 aa)
	I79_005386	Gamma-secretase subunit APH-1B. (196 aa)
	Erap1	Aminopeptidase. (941 aa)
	Ncstn	Nicastrin. (615 aa)
	Dag1	Dystroglycan. (893 aa)
	I79_009201	Myeloblastin; Belongs to the peptidase S1 family. (211 aa)
	Sppl2b	Signal peptide peptidase-like 2B. (425 aa)
	I79_009291	Beta-secretase 2; Belongs to the peptidase A1 family. (378 aa)
	Adam19	Disintegrin and metalloproteinase domain-containing protein 19. (402 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
	Bace1	Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
	I79_023268	Disintegrin and metalloproteinase domain-containing protein 17. (527 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam10	Aph1a	G3GRM2	G3H2V5	Disintegrin and metalloproteinase domain-containing protein 10.	Gamma-secretase subunit APH-1A.	0.540
Adam10	Bace1	G3GRM2	G3IAK4	Disintegrin and metalloproteinase domain-containing protein 10.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.776
Adam10	Ncstn	G3GRM2	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 10.	Nicastrin.	0.847
Adam10	Psen1	G3GRM2	G3HNF2	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.781
Adam10	Psen2	G3GRM2	G3HV76	Disintegrin and metalloproteinase domain-containing protein 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.719
Aph1a	Adam10	G3H2V5	G3GRM2	Gamma-secretase subunit APH-1A.	Disintegrin and metalloproteinase domain-containing protein 10.	0.540
Aph1a	Bace1	G3H2V5	G3IAK4	Gamma-secretase subunit APH-1A.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.582
Aph1a	Ncstn	G3H2V5	G3H7X9	Gamma-secretase subunit APH-1A.	Nicastrin.	0.999
Aph1a	Psen1	G3H2V5	G3HNF2	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.999
Aph1a	Psen2	G3H2V5	G3HV76	Gamma-secretase subunit APH-1A.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
Bace1	Adam10	G3IAK4	G3GRM2	Beta-secretase 1; Belongs to the peptidase A1 family.	Disintegrin and metalloproteinase domain-containing protein 10.	0.776
Bace1	Aph1a	G3IAK4	G3H2V5	Beta-secretase 1; Belongs to the peptidase A1 family.	Gamma-secretase subunit APH-1A.	0.582
Bace1	Ncstn	G3IAK4	G3H7X9	Beta-secretase 1; Belongs to the peptidase A1 family.	Nicastrin.	0.812
Bace1	Psen1	G3IAK4	G3HNF2	Beta-secretase 1; Belongs to the peptidase A1 family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.904
Bace1	Psen2	G3IAK4	G3HV76	Beta-secretase 1; Belongs to the peptidase A1 family.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.731
I79_004035	Ncstn	G3H1K6	G3H7X9	Disintegrin and metalloproteinase domain-containing protein 9.	Nicastrin.	0.478
I79_005385	Ncstn	G3H516	G3H7X9	Gamma-secretase subunit APH-1B.	Nicastrin.	0.961
I79_005385	Psen1	G3H516	G3HNF2	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_005385	Psen2	G3H516	G3HV76	Gamma-secretase subunit APH-1B.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.951
I79_005386	Ncstn	G3H517	G3H7X9	Gamma-secretase subunit APH-1B.	Nicastrin.	0.961