(52 nodes) JNK cascade network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_021837	Leucine-rich repeat serine/threonine-protein kinase 2. (441 aa)
	I79_022944	Mitogen-activated protein kinase. (343 aa)
	Mapk8ip2	C-jun-amino-terminal kinase-interacting protein 2. (829 aa)
	Tlr3	Toll-like receptor 3. (164 aa)
	I79_025482	Nuclear factor NF-kappa-B p105 subunit. (144 aa)
	Nfkb1	Nuclear factor NF-kappa-B p105 subunit. (509 aa)
	Trib1	Tribbles-like 1. (286 aa)
	Smad3	Mothers against decapentaplegic homolog. (363 aa)
	Dusp19	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (220 aa)
	I79_005745	NADPH oxidase 1. (395 aa)
	Nod2	Nucleotide-binding oligomerization domain-containing protein 2. (989 aa)
	Atf2	Cyclic AMP-dependent transcription factor ATF-2. (487 aa)
	Map2k4	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (342 aa)
	Traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (508 aa)
	Mapk8ip1	C-jun-amino-terminal kinase-interacting protein 1. (617 aa)
	Gps2	G protein pathway suppressor 2. (327 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Map3k20	Mitogen-activated protein kinase kinase kinase MLT. (445 aa)
	I79_001275	Uncharacterized protein. (119 aa)
	I79_000697	Mitogen-activated protein kinase kinase kinase 7. (287 aa)
	I79_007935	C-jun-amino-terminal kinase-interacting protein 3. (95 aa)
	Mapk8ip3	C-jun-amino-terminal kinase-interacting protein 3. (1073 aa)
	Sh2d3a	SH2 domain-containing protein 3A. (263 aa)
	Tnfsf11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (199 aa)
	I79_010073	Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
	Map3k1	Mitogen-activated protein kinase kinase kinase 1. (1340 aa)
	Map4k1	Mitogen-activated protein kinase kinase kinase kinase 1. (83 aa)
	Stk3	Serine/threonine-protein kinase 3. (260 aa)
	Map3k13	Mitogen-activated protein kinase kinase kinase 13. (431 aa)
	Mapk9	Mitogen-activated protein kinase 9. (303 aa)
	Ripk2	Receptor-interacting serine/threonine-protein kinase 2. (402 aa)
	I79_012794	Nephrin. (1049 aa)
	I79_012926	Death domain-associated protein 6. (393 aa)
	Myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	Map2k7	Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
	Irak1	Interleukin-1 receptor-associated kinase 1. (494 aa)
	I79_014483	Serine/threonine-protein kinase 3. (118 aa)
	Stradb	STE20-related kinase adapter protein beta. (419 aa)
	Hacd3	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (371 aa)
	Map3k12	Mitogen-activated protein kinase kinase kinase 12. (274 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	Nod1	Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
	I79_016051	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
	Tnf	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	Daxx	Death domain-associated protein 6. (708 aa)
	Ptk2	Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
	Tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1033 aa)
	Irak4	Interleukin-1 receptor-associated kinase 4. (462 aa)
	Map3k11	Mitogen-activated protein kinase kinase kinase. (850 aa)
	I79_021835	Leucine-rich repeat serine/threonine-protein kinase 2. (354 aa)
	I79_021836	Leucine-rich repeat serine/threonine-protein kinase 2. (1184 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atf2	I79_022944	G3H1V4	G3IGM4	Cyclic AMP-dependent transcription factor ATF-2.	Mitogen-activated protein kinase.	0.948
Atf2	Mapk9	G3H1V4	G3HP57	Cyclic AMP-dependent transcription factor ATF-2.	Mitogen-activated protein kinase 9.	0.826
Daxx	Mapk9	G3I6W2	G3HP57	Death domain-associated protein 6.	Mitogen-activated protein kinase 9.	0.910
Dusp19	I79_022944	G3H8H2	G3IGM4	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.415
Dusp19	Map2k7	G3H8H2	G3HRS0	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity mitogen-activated protein kinase kinase 7.	0.637
Dusp19	Mapk9	G3H8H2	G3HP57	Dual specificity protein phosphatase 19-like protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase 9.	0.454
I79_000697	Irak1	G3GSS8	G3HSV4	Mitogen-activated protein kinase kinase kinase 7.	Interleukin-1 receptor-associated kinase 1.	0.767
I79_000697	Map2k4	G3GSS8	G3GZ46	Mitogen-activated protein kinase kinase kinase 7.	Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	0.949
I79_000697	Map2k7	G3GSS8	G3HRS0	Mitogen-activated protein kinase kinase kinase 7.	Dual specificity mitogen-activated protein kinase kinase 7.	0.726
I79_000697	Mapk9	G3GSS8	G3HP57	Mitogen-activated protein kinase kinase kinase 7.	Mitogen-activated protein kinase 9.	0.402
I79_000697	Myd88	G3GSS8	G3HQV3	Mitogen-activated protein kinase kinase kinase 7.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.968
I79_000697	Nod1	G3GSS8	G3HX20	Mitogen-activated protein kinase kinase kinase 7.	Nucleotide-binding oligomerization domain-containing protein 1.	0.501
I79_000697	Nod2	G3GSS8	G3H5L9	Mitogen-activated protein kinase kinase kinase 7.	Nucleotide-binding oligomerization domain-containing protein 2.	0.555
I79_000697	Ripk2	G3GSS8	G3HP95	Mitogen-activated protein kinase kinase kinase 7.	Receptor-interacting serine/threonine-protein kinase 2.	0.703
I79_000697	Smad3	G3GSS8	G3H8N9	Mitogen-activated protein kinase kinase kinase 7.	Mothers against decapentaplegic homolog.	0.420
I79_000697	Tlr3	G3GSS8	G3IHU2	Mitogen-activated protein kinase kinase kinase 7.	Toll-like receptor 3.	0.924
I79_000697	Tlr4	G3GSS8	G3I192	Mitogen-activated protein kinase kinase kinase 7.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.951
I79_000697	Tnf	G3GSS8	G3HZG9	Mitogen-activated protein kinase kinase kinase 7.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.960
I79_000697	Traf6	G3GSS8	G3GZ05	Mitogen-activated protein kinase kinase kinase 7.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.993
I79_001275	Irak1	G3GUC1	G3HSV4	Uncharacterized protein.	Interleukin-1 receptor-associated kinase 1.	0.487