(49 nodes) Neuroblast proliferation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fzd9	Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (439 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	Fgf13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (117 aa)
	Nde1	Nuclear distribution protein nudE-like 1. (344 aa)
	Arhgef2	Rho guanine nucleotide exchange factor 2. (1031 aa)
	I79_010136	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
	I79_010251	AT-hook-containing transcription factor. (1259 aa)
	Eml1	Echinoderm microtubule-associated protein-like 1. (184 aa)
	I79_011753	Abnormal spindle-like microcephaly-associated protein-like. (416 aa)
	Aspm	Abnormal spindle-like microcephaly-associated protein-like. (1831 aa)
	Numb	Protein numb-like; Belongs to the histone H2A family. (702 aa)
	I79_012741	Kinesin-associated protein 3. (610 aa)
	Zzef1	Zinc finger ZZ-type and EF-hand domain-containing protein 1. (866 aa)
	I79_013725	Zinc finger ZZ-type and EF-hand domain-containing protein 1. (150 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	Prox1	Prospero homeobox protein 1. (738 aa)
	Dct	L-dopachrome tautomerase. (517 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Kcna1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
	Daglb	Sn1-specific diacylglycerol lipase beta. (167 aa)
	I79_025778	Plexin-B2. (340 aa)
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	Dagla	Sn1-specific diacylglycerol lipase alpha. (1043 aa)
	I79_020343	Cardiotrophin-2. (229 aa)
	Sox10	Transcription factor SOX-10. (466 aa)
	I79_017833	Lymphoid enhancer-binding factor 1. (276 aa)
	I79_017750	Plexin-B2. (1753 aa)
	Neurod4	Neurogenic differentiation factor. (331 aa)
	Tead3	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (373 aa)
	Itgb1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	Frs2	Fibroblast growth factor receptor substrate 2. (509 aa)
	Hif1a	Hypoxia-inducible factor 1 alpha. (820 aa)
	Racgap1	Rac GTPase-activating protein 1. (628 aa)
	I79_015412	Plexin-B2. (376 aa)
	I79_001652	Sn1-specific diacylglycerol lipase beta. (154 aa)
	I79_002496	Nuclear receptor subfamily 2 group E member 1. (323 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Pax6	Paired box protein Pax-6. (544 aa)
	Dock7	Dedicator of cytokinesis protein 7; Belongs to the DOCK family. (540 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	Drd2	D(2) dopamine receptor. (274 aa)
	I79_004403	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (187 aa)
	I79_004750	Transcription factor SOX-5. (211 aa)
	Sox5	Transcription factor SOX-5. (347 aa)
	Ascl1	Achaete-scute-like 1. (140 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Hhip	Hedgehog-interacting protein. (671 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aspm	I79_001046	G3HM10	G3GTQ9	Abnormal spindle-like microcephaly-associated protein-like.	Neurofibromin.	0.435
Aspm	I79_011753	G3HM10	G3HM09	Abnormal spindle-like microcephaly-associated protein-like.	Abnormal spindle-like microcephaly-associated protein-like.	0.928
Aspm	Nde1	G3HM10	G3HFN0	Abnormal spindle-like microcephaly-associated protein-like.	Nuclear distribution protein nudE-like 1.	0.742
Aspm	Racgap1	G3HM10	G3HX62	Abnormal spindle-like microcephaly-associated protein-like.	Rac GTPase-activating protein 1.	0.595
Dagla	Daglb	G3IFK5	G3GVB6	Sn1-specific diacylglycerol lipase alpha.	Sn1-specific diacylglycerol lipase beta.	0.930
Daglb	Dagla	G3GVB6	G3IFK5	Sn1-specific diacylglycerol lipase beta.	Sn1-specific diacylglycerol lipase alpha.	0.930
Daglb	I79_001652	G3GVB6	G3GVB7	Sn1-specific diacylglycerol lipase beta.	Sn1-specific diacylglycerol lipase beta.	0.858
Drd2	I79_004403	G3H2I9	G3H2J0	D(2) dopamine receptor.	D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.	0.926
Eml1	I79_001046	G3HIW8	G3GTQ9	Echinoderm microtubule-associated protein-like 1.	Neurofibromin.	0.454
Eml1	Nde1	G3HIW8	G3HFN0	Echinoderm microtubule-associated protein-like 1.	Nuclear distribution protein nudE-like 1.	0.518
Eml1	PAFAH1B1	G3HIW8	G3HVB8	Echinoderm microtubule-associated protein-like 1.	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.444
Fgf13	Fgfr2	G3HB47	G3IJY0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 2.	0.822
Fgf13	Frs2	G3HB47	G3HZ39	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2.	0.494
Fgf13	I79_004031	G3HB47	G3H1K2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.798
Fgf13	I79_006225	G3HB47	G3H796	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sonic hedgehog protein.	0.405
Fgfr2	Fgf13	G3IJY0	G3HB47	Fibroblast growth factor receptor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.822
Fgfr2	Frs2	G3IJY0	G3HZ39	Fibroblast growth factor receptor 2.	Fibroblast growth factor receptor substrate 2.	0.951
Fgfr2	I79_004031	G3IJY0	G3H1K2	Fibroblast growth factor receptor 2.	Fibroblast growth factor receptor.	0.429
Frs2	Fgf13	G3HZ39	G3HB47	Fibroblast growth factor receptor substrate 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.494
Frs2	Fgfr2	G3HZ39	G3IJY0	Fibroblast growth factor receptor substrate 2.	Fibroblast growth factor receptor 2.	0.951