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Ak1 Ak1 I79_000224 I79_000224 Gart Gart Nt5e Nt5e I79_000934 I79_000934 Urad Urad Adk Adk I79_002513 I79_002513 Pfas Pfas IMPDH IMPDH Gmps Gmps Mpp6 Mpp6 I79_005344 I79_005344 I79_006155 I79_006155 Adss2 Adss2 Ak2 Ak2 GMPR GMPR Hprt1 Hprt1 I79_009773 I79_009773 I79_009922 I79_009922 I79_010131 I79_010131 Nt5dc1 Nt5dc1 Ada Ada I79_011952 I79_011952 Nt5c1a Nt5c1a I79_013073 I79_013073 AK3 AK3 Adsl Adsl Ak4 Ak4 Ampd3 Ampd3 DNPH1 DNPH1 Atic Atic I79_018279 I79_018279 Dck Dck Xdh Xdh I79_018438 I79_018438 Ampd2 Ampd2 Nudt2 Nudt2 I79_020339 I79_020339 Prps2 Prps2 I79_021535 I79_021535 Ppat Ppat Paics Paics I79_022567 I79_022567 Nt5c2 Nt5c2 I79_023016 I79_023016 Gda Gda I79_025923 I79_025923 IMPDH2 IMPDH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ak1Adenylate kinase isoenzyme 1; Belongs to the adenylate kinase family. (54 aa)
I79_000224Adenine phosphoribosyltransferase. (192 aa)
GartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
Nt5e5'-nucleotidase; Belongs to the 5'-nucleotidase family. (556 aa)
I79_0009345'(3')-deoxyribonucleotidase, cytosolic type. (236 aa)
Urad2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. (188 aa)
AdkAdenosine kinase. (361 aa)
I79_002513Uncharacterized protein C6orf224. (1162 aa)
PfasPhosphoribosylformylglycinamidine synthase. (1338 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (437 aa)
GmpsGMP synthase [glutamine-hydrolyzing]. (1159 aa)
Mpp6MAGUK p55 subfamily member 6; Belongs to the MAGUK family. (512 aa)
I79_005344Adenylate kinase isoenzyme 4, mitochondrial. (106 aa)
I79_006155Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (146 aa)
Adss2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (355 aa)
Ak2Adenylate kinase 2, mitochondrial; Belongs to the adenylate kinase family. (142 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
Hprt1Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
I79_009773Cytosolic 5'-nucleotidase 1B. (632 aa)
I79_009922Leucine-rich repeat and guanylate kinase domain-containing protein. (554 aa)
I79_010131Guanylate kinase. (210 aa)
Nt5dc15'-nucleotidase domain-containing protein 1. (443 aa)
AdaAdenosine deaminase. (363 aa)
I79_011952Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (264 aa)
Nt5c1aCytosolic 5'-nucleotidase 1A. (365 aa)
I79_013073AMP deaminase 1. (78 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
AdslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
Ak4Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (161 aa)
Ampd3AMP deaminase 3. (102 aa)
DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (163 aa)
AticBifunctional purine biosynthesis protein PURH. (592 aa)
I79_018279Deoxyguanosine kinase, mitochondrial. (216 aa)
DckDeoxycytidine kinase. (260 aa)
XdhXanthine dehydrogenase/oxidase. (1332 aa)
I79_018438Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (202 aa)
Ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa)
Nudt2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
I79_020339Guanine deaminase. (70 aa)
Prps2Ribose-phosphate pyrophosphokinase 2. (318 aa)
I79_021535Phosphoribosyltransferase domain-containing protein 1. (80 aa)
PpatAmidophosphoribosyltransferase. (251 aa)
PaicsMultifunctional protein ADE2. (87 aa)
I79_022567Amidophosphoribosyltransferase. (90 aa)
Nt5c2Cytosolic purine 5'-nucleotidase. (560 aa)
I79_023016Adenylate kinase isoenzyme 4, mitochondrial; Belongs to the adenylate kinase family. (250 aa)
GdaGuanine deaminase. (213 aa)
I79_025923Adenylate kinase 2, mitochondrial; Belongs to the adenylate kinase family. (77 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. (514 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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