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Uprt Uprt IMPDH2 IMPDH2 I79_022567 I79_022567 Paics Paics Ppat Ppat I79_021535 I79_021535 Upp1 Upp1 Prps2 Prps2 Nudt2 Nudt2 Ampd2 Ampd2 I79_018923 I79_018923 Dck Dck I79_017541 I79_017541 Atic Atic Ampd3 Ampd3 Adsl Adsl I79_014878 I79_014878 I79_014877 I79_014877 I79_013073 I79_013073 Uck2 Uck2 Ada Ada Upp2 Upp2 Uckl1 Uckl1 I79_009898 I79_009898 Hprt1 Hprt1 CgPICR_016797 CgPICR_016797 Dhodh Dhodh Adss2 Adss2 Gmps Gmps IMPDH IMPDH Pfas Pfas Cad Cad Adk Adk Gart Gart Umps Umps I79_000224 I79_000224
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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UprtUracil phosphoribosyltransferase. (306 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family. (514 aa)
I79_022567Amidophosphoribosyltransferase. (90 aa)
PaicsMultifunctional protein ADE2. (87 aa)
PpatAmidophosphoribosyltransferase. (251 aa)
I79_021535Phosphoribosyltransferase domain-containing protein 1. (80 aa)
Upp1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (282 aa)
Prps2Ribose-phosphate pyrophosphokinase 2. (318 aa)
Nudt2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
Ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (798 aa)
I79_018923Ribose-phosphate pyrophosphokinase 1. (177 aa)
DckDeoxycytidine kinase. (260 aa)
I79_017541Uridine-cytidine kinase 1. (178 aa)
AticBifunctional purine biosynthesis protein PURH. (592 aa)
Ampd3AMP deaminase 3. (102 aa)
AdslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (484 aa)
I79_014878Ribose-phosphate pyrophosphokinase 1. (132 aa)
I79_014877Ribose-phosphate pyrophosphokinase 1. (192 aa)
I79_013073AMP deaminase 1. (78 aa)
Uck2Uridine-cytidine kinase 2. (235 aa)
AdaAdenosine deaminase. (363 aa)
Upp2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (250 aa)
Uckl1Uridine-cytidine kinase; Belongs to the uridine kinase family. (334 aa)
I79_009898Uridine-cytidine kinase-like 1. (213 aa)
Hprt1Hypoxanthine-guanine phosphoribosyltransferase. (76 aa)
CgPICR_016797Ribose-phosphate pyrophosphokinase 1. (318 aa)
DhodhDihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
Adss2Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (355 aa)
GmpsGMP synthase [glutamine-hydrolyzing]. (1159 aa)
IMPDHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (437 aa)
PfasPhosphoribosylformylglycinamidine synthase. (1338 aa)
CadCAD protein. (2225 aa)
AdkAdenosine kinase. (361 aa)
GartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
UmpsUridine 5'-monophosphate synthase. (480 aa)
I79_000224Adenine phosphoribosyltransferase. (192 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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