STRINGSTRING
Slc26a6 Slc26a6 Glul-2 Glul-2 Glp1r Glp1r Gck Gck I79_012336 I79_012336 Xbp1 Xbp1 Hmgcs2 Hmgcs2 H671_21027 H671_21027 Pdk3 Pdk3 Acvr2b Acvr2b P2rx3 P2rx3 I79_013440 I79_013440 Map2k7 Map2k7 Ppard Ppard Smad4 Smad4 I79_014316 I79_014316 I79_014317 I79_014317 Apoa2 Apoa2 I79_014629 I79_014629 Gper1 Gper1 I79_014954 I79_014954 I79_015169 I79_015169 Sod2 Sod2 Eif2b1 Eif2b1 H671_3g9558 H671_3g9558 Rab11fip5 Rab11fip5 I79_016038 I79_016038 Adipoq Adipoq Nr0b2 Nr0b2 Srf Srf Hif1a Hif1a Dicer1 Dicer1 Ager Ager I79_016423 I79_016423 Ppp2ca Ppp2ca Oprk1 Oprk1 Mapk13 Mapk13 I79_016638 I79_016638 Nqo1 Nqo1 Grik5 Grik5 Hnf4a Hnf4a I79_017077 I79_017077 IL1B IL1B Pik3ca Pik3ca I79_017273 I79_017273 Fn1 Fn1 Lyn Lyn I79_017561 I79_017561 Eif2b5 Eif2b5 I79_017935 I79_017935 CgPICR_009543 CgPICR_009543 Znf236 Znf236 Gjd3 Gjd3 Rab11b Rab11b Hnf1b Hnf1b Men1 Men1 Apoc3 Apoc3 Gas6 Gas6 I79_020109 I79_020109 Slc37a4 Slc37a4 Prkcb Prkcb Nox4 Nox4 Ucp3 Ucp3 Tgfb1 Tgfb1 Sidt2 Sidt2 Enpp1 Enpp1 Polg Polg I79_020697 I79_020697 Rmi1 Rmi1 I79_020783 I79_020783 I79_021155 I79_021155 Vcam1 Vcam1 Kat5 Kat5 Prlh Prlh Testin-2 Testin-2 I79_022343 I79_022343 I79_022515 I79_022515 I79_022778 I79_022778 Rab34 Rab34 I79_023112 I79_023112 I79_023475 I79_023475 Ccdc186 Ccdc186 Tcf7l2 Tcf7l2 Twnk Twnk I79_024097 I79_024097 Slc2a5 Slc2a5 Irs2 Irs2 Serpinf1 Serpinf1 I79_024779 I79_024779 I79_024850 I79_024850 Txn2 Txn2 I79_025440 I79_025440 I79_025441 I79_025441 I79_025482 I79_025482 I79_025502 I79_025502 Nfkb1 Nfkb1 Guca2b Guca2b Myc Myc I79_025799 I79_025799 I79_025828 I79_025828 I79_026091 I79_026091 Gja1 Gja1 ICAM1 ICAM1 Ucn3 Ucn3 Cdt1 Cdt1 I79_000233 I79_000233 Trh Trh I79_000439 I79_000439 I79_000983 I79_000983 Sarm1 Sarm1 CgPICR_003438 CgPICR_003438 Tgfbr2 Tgfbr2 Map2k3 Map2k3 I79_002020 I79_002020 Ptgs2 Ptgs2 Slc6a1 Slc6a1 I79_002364 I79_002364 Foxo3 Foxo3 I79_002566 I79_002566 Eif2b4 Eif2b4 Cat Cat Map2k4 Map2k4 Lep Lep Fkbp1b Fkbp1b I79_003342 I79_003342 Apob Apob Pfkfb2 Pfkfb2 Zbtb20 Zbtb20 Slc30a8 Slc30a8 Sin3a Sin3a Zfp36l1 Zfp36l1 Sesn2 Sesn2 I79_004339 I79_004339 Txnip Txnip Tjp1 Tjp1 Igf1 Igf1 Keap1 Keap1 I79_006180 I79_006180 Rab11fip2 Rab11fip2 I79_006547 I79_006547 Adipor2 Adipor2 Gpx1 Gpx1 Pfkl Pfkl Col6a2 Col6a2 I79_006833 I79_006833 Rasal2 Rasal2 I79_007247 I79_007247 Smad2 Smad2 Cdkn1b Cdkn1b I79_007744 I79_007744 Angpt2 Angpt2 Pck1 Pck1 Pklr Pklr Runx2 Runx2 I79_008089 I79_008089 P2rx2 P2rx2 I79_008252 I79_008252 Prkca Prkca Prkaca Prkaca Cyp7a1 Cyp7a1 Pck2 Pck2 Neurod1 Neurod1 Gpld1 Gpld1 Aqp4 Aqp4 Kcnb1 Kcnb1 I79_009077 I79_009077 Adnp Adnp Egr1 Egr1 Eif2b2 Eif2b2 I79_009536 I79_009536 Glul Glul I79_009560 I79_009560 Selenot Selenot I79_009910 I79_009910 I79_009987 I79_009987 Prkaa1 Prkaa1 I79_010155 I79_010155 I79_010194 I79_010194 Thbs1 Thbs1 I79_010330 I79_010330 Slc12a6 Slc12a6 Map1b Map1b Gclc Gclc Rps6kb1 Rps6kb1 I79_010864 I79_010864 I79_010883 I79_010883 I79_010901 I79_010901 Rack1 Rack1 I79_011051 I79_011051 Igf1r Igf1r Tra2b Tra2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Slc26a6Solute carrier family 26 member 6. (637 aa)
Glul-2Glutamine synthetase. (373 aa)
Glp1rGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (437 aa)
GckPhosphotransferase. (465 aa)
I79_012336Protein tyrosine kinase 2 beta. (53 aa)
Xbp1X-box binding protein 1 isoform 1. (330 aa)
Hmgcs23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
H671_21027DNA excision repair protein ERCC-1. (111 aa)
Pdk3Protein-serine/threonine kinase. (415 aa)
Acvr2bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (559 aa)
P2rx3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (464 aa)
I79_013440Calcitonin gene-related peptide type 1 receptor. (426 aa)
Map2k7Dual specificity mitogen-activated protein kinase kinase 7. (391 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
Smad4Mothers against decapentaplegic-like 4. (259 aa)
I79_014316Receptor-type tyrosine-protein phosphatase N2. (234 aa)
I79_014317Receptor-type tyrosine-protein phosphatase N2. (503 aa)
Apoa2Apolipoprotein A-II-like protein. (101 aa)
I79_014629Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (369 aa)
Gper1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
I79_014954Autophagy-related protein 7. (439 aa)
I79_015169Ras GTPase-activating protein nGAP. (1105 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
Eif2b1Translation initiation factor eIF-2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (223 aa)
H671_3g9558Tyrosine 3-monooxygenase-like protein. (542 aa)
Rab11fip5Rab11 family-interacting protein 5. (1353 aa)
I79_016038Rab11 family-interacting protein 5. (51 aa)
AdipoqAdiponectin. (248 aa)
Nr0b2Nuclear receptor subfamily 0 group B member 2. (260 aa)
SrfSerum response factor. (361 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
Dicer1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
Ppp2caSerine/threonine-protein phosphatase. (303 aa)
Oprk1Kappa-type opioid receptor. (176 aa)
Mapk13Mitogen-activated protein kinase. (278 aa)
I79_016638Protein phosphatase 1 regulatory subunit 15A. (445 aa)
Nqo1NAD(P)H dehydrogenase [quinone] 1. (274 aa)
Grik5Glutamate receptor, ionotropic kainate 5. (118 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (464 aa)
I79_017077Acetoacetyl-CoA synthetase. (634 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Pik3caPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
I79_017273Protein kinase C alpha type. (128 aa)
Fn1Fibronectin. (2486 aa)
LynTyrosine-protein kinase. (289 aa)
I79_017561Tyrosine-protein kinase Lyn. (101 aa)
Eif2b5Translation initiation factor eIF-2B subunit epsilon. (716 aa)
I79_017935Lin-28-like A. (169 aa)
CgPICR_009543RNA-binding protein 4. (360 aa)
Znf236Zinc finger protein 236. (1829 aa)
Gjd3Gap junction delta-3 protein. (137 aa)
Rab11bRas-related protein Rab-11B. (218 aa)
Hnf1bHepatocyte nuclear factor 1-beta. (593 aa)
Men1Menin. (610 aa)
Apoc3Apolipoprotein C-III. (76 aa)
Gas6Growth arrest-specific protein 6. (684 aa)
I79_020109Glucose-6-phosphate translocase. (141 aa)
Slc37a4Glucose-6-phosphate translocase. (285 aa)
PrkcbNon-specific serine/threonine protein kinase. (544 aa)
Nox4NADPH oxidase 4. (130 aa)
Ucp3Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (650 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
Sidt2SID1 transmembrane family member 2. (535 aa)
Enpp1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (906 aa)
PolgDNA polymerase subunit gamma-1. (1215 aa)
I79_020697Glycerol-3-phosphate acyltransferase 1, mitochondrial. (980 aa)
Rmi1RecQ-mediated genome instability protein 1. (618 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
I79_021155Paired box protein Pax-2. (503 aa)
Vcam1Vascular cell adhesion protein 1. (220 aa)
Kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
PrlhProlactin-releasing peptide. (87 aa)
Testin-2Testin-2; Belongs to the peptidase C1 family. (401 aa)
I79_022343UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (1444 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
I79_022778Glutamate--cysteine ligase regulatory subunit. (225 aa)
Rab34Ras-related protein Rab-34. (259 aa)
I79_023112Glutamine synthetase; Belongs to the glutamine synthetase family. (130 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
Ccdc186Uncharacterized protein C10orf118-like. (900 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
TwnkTwinkle protein, mitochondrial. (690 aa)
I79_024097Vascular cell adhesion protein 1. (225 aa)
Slc2a5Solute carrier family 2, facilitated glucose transporter member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
Irs2Insulin receptor substrate 2. (465 aa)
Serpinf1Pigment epithelium-derived factor; Belongs to the serpin family. (94 aa)
I79_024779Homeobox protein Nkx-6.1. (99 aa)
I79_024850Patatin-like phospholipase domain-containing protein 3. (273 aa)
Txn2Thioredoxin, mitochondrial. (64 aa)
I79_025440Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
I79_025441Receptor-type tyrosine-protein phosphatase-like N. (761 aa)
I79_025482Nuclear factor NF-kappa-B p105 subunit. (144 aa)
I79_025502Adenylate cyclase type 8. (333 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (509 aa)
Guca2bGuanylate cyclase activator 2B. (107 aa)
MycMyc proto-oncogene protein. (281 aa)
I79_025799Sterile alpha and TIR motif-containing protein 1. (156 aa)
I79_025828Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (184 aa)
I79_026091Pigment epithelium-derived factor; Belongs to the serpin family. (58 aa)
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
ICAM1Intercellular adhesion molecule 1. (527 aa)
Ucn3Urocortin-3. (162 aa)
Cdt1DNA replication factor Cdt1. (553 aa)
I79_000233Cytochrome b-245 light chain. (206 aa)
TrhPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (247 aa)
I79_000439Phosphoinositide phospholipase C. (949 aa)
I79_000983Non-specific serine/threonine protein kinase. (747 aa)
Sarm1Sterile alpha and TIR motif-containing protein 1. (705 aa)
CgPICR_003438C-C motif chemokine. (143 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Map2k3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (340 aa)
I79_002020Glucokinase regulatory protein. (583 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Slc6a1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
I79_002364Neuronal pentraxin-1. (416 aa)
Foxo3Forkhead box protein O3. (672 aa)
I79_002566Ketohexokinase. (345 aa)
Eif2b4Translation initiation factor eIF-2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (525 aa)
CatCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (555 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (342 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Fkbp1bPeptidylprolyl isomerase. (143 aa)
I79_003342Apolipoprotein B-100. (946 aa)
ApobApolipoprotein B-100. (3537 aa)
Pfkfb26-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2. (784 aa)
Zbtb20Zinc finger and BTB domain-containing protein 20. (741 aa)
Slc30a8Zinc transporter 8. (285 aa)
Sin3aPaired amphipathic helix protein Sin3a. (1274 aa)
Zfp36l1Butyrate response factor 1. (338 aa)
Sesn2Sestrin-2. (480 aa)
I79_004339Serine/threonine-protein phosphatase. (244 aa)
TxnipThioredoxin-interacting protein. (229 aa)
Tjp1Tight junction protein ZO-1. (762 aa)
Igf1Insulin-like growth factor I. (75 aa)
Keap1Kelch-like ECH-associated protein 1. (624 aa)
I79_006180Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (627 aa)
Rab11fip2Rab11 family-interacting protein 2. (452 aa)
I79_006547Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (311 aa)
Adipor2Adiponectin receptor protein 2. (386 aa)
Gpx1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (145 aa)
Pfkl6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (745 aa)
Col6a2Collagen alpha-2(VI) chain. (259 aa)
I79_006833Collagen alpha-2(VI) chain. (774 aa)
Rasal2Ras GTPase-activating protein SynGAP. (161 aa)
I79_007247Williams-Beuren syndrome chromosomal region 14 protein-like. (709 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Cdkn1bCyclin-dependent kinase inhibitor 1B. (198 aa)
I79_007744Angiopoietin-2. (188 aa)
Angpt2Angiopoietin-2. (288 aa)
Pck1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PklrPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
Runx2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (365 aa)
I79_008089Equilibrative nucleoside transporter 1. (184 aa)
P2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (504 aa)
I79_008252Guanylate cyclase activator 2B. (104 aa)
PrkcaNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (487 aa)
PrkacacAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (360 aa)
Pck2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
Neurod1Neurogenic differentiation factor. (355 aa)
Gpld1Phosphatidylinositol-glycan-specific phospholipase D. (778 aa)
Aqp4Aquaporin-4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (236 aa)
Kcnb1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (706 aa)
I79_009077Potassium voltage-gated channel subfamily B member 1. (188 aa)
AdnpActivity-dependent neuroprotector homeobox protein. (1102 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Eif2b2Translation initiation factor eIF-2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (257 aa)
I79_009536Neutrophil cytosol factor 2. (515 aa)
GlulGlutamine synthetase; Belongs to the glutamine synthetase family. (297 aa)
I79_009560Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (58 aa)
SelenotSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
I79_009910Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (655 aa)
I79_009987Collectrin. (118 aa)
Prkaa1Non-specific serine/threonine protein kinase. (477 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
I79_010194Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (387 aa)
Thbs1Thrombospondin-1. (533 aa)
I79_010330Hepatocyte nuclear factor 1-alpha. (668 aa)
Slc12a6Solute carrier family 12 member 6. (1150 aa)
Map1bMicrotubule-associated protein 1B. (2371 aa)
GclcGlutamate--cysteine ligase catalytic subunit. (584 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
I79_010864Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (372 aa)
I79_010883Gastric inhibitory polypeptide. (205 aa)
I79_010901Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (584 aa)
Rack1Guanine nucleotide-binding protein subunit beta-2-like 1. (276 aa)
I79_011051Non-specific serine/threonine protein kinase. (644 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
Tra2bTransformer-2 protein-like beta. (288 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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