(40 nodes) Regulation of mesenchymal cell proliferation network (Cricetulus griseus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Fgfr2	Fibroblast growth factor receptor 2. (659 aa)
	Irs2	Insulin receptor substrate 2. (465 aa)
	Ctnnbip1	Beta-catenin-interacting protein 1. (81 aa)
	Myc	Myc proto-oncogene protein. (281 aa)
	Foxf1	Forkhead box protein F1. (320 aa)
	Foxp1	Forkhead box protein P1. (696 aa)
	I79_000899	T-box transcription factor TBX18. (498 aa)
	I79_000973	Transcription factor SOX-10. (360 aa)
	Wnt5a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	Tgfbr2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	Foxp2	Forkhead box protein P2. (492 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	I79_004031	Fibroblast growth factor receptor. (731 aa)
	I79_006254	Bone morphogenetic protein 4. (406 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	I79_006679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	Ptn	Pleiotrophin. (168 aa)
	I79_007641	Low-density lipoprotein receptor-related protein 6. (543 aa)
	Lrp6	Low-density lipoprotein receptor-related protein 6. (565 aa)
	Nfib	Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (561 aa)
	I79_009030	T-box transcription factor TBX1. (293 aa)
	I79_009343	N-myc proto-oncogene protein. (316 aa)
	Lmna	Lamin-A/C; Belongs to the intermediate filament family. (563 aa)
	I79_009932	Paired mesoderm homeobox protein 2. (163 aa)
	Zeb1	Zinc finger E-box-binding homeobox 1. (1078 aa)
	Prrx1	Paired mesoderm homeobox protein 1. (198 aa)
	I79_013259	PHD finger protein 14. (706 aa)
	Wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	Ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (918 aa)
	I79_016814	Short stature homeobox protein 2. (194 aa)
	H671_4g11668	Chordin. (842 aa)
	Fbxw4	F-box/WD repeat-containing protein 4. (292 aa)
	Lrp5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1608 aa)
	Arhgap5	Rho GTPase-activating protein 5. (1502 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_022034	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1150 aa)
	Prrx2	Paired mesoderm homeobox protein 2. (185 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ctnnb1	Ctnnbip1	G3H996	G3IKH6	Catenin beta-1.	Beta-catenin-interacting protein 1.	0.999
Ctnnb1	Fgfr2	G3H996	G3IJY0	Catenin beta-1.	Fibroblast growth factor receptor 2.	0.527
Ctnnb1	H671_4g11668	G3H996	G3I302	Catenin beta-1.	Chordin.	0.447
Ctnnb1	I79_000973	G3H996	G3GTI9	Catenin beta-1.	Transcription factor SOX-10.	0.781
Ctnnb1	I79_004031	G3H996	G3H1K2	Catenin beta-1.	Fibroblast growth factor receptor.	0.690
Ctnnb1	I79_006225	G3H996	G3H796	Catenin beta-1.	Sonic hedgehog protein.	0.553
Ctnnb1	I79_006254	G3H996	G3H7C4	Catenin beta-1.	Bone morphogenetic protein 4.	0.448
Ctnnb1	I79_007641	G3H996	G3HB26	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	I79_022034	G3H996	G3IE90	Catenin beta-1.	Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.695
Ctnnb1	Lrp5	G3H996	G3I5B4	Catenin beta-1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.738
Ctnnb1	Lrp6	G3H996	G3HB27	Catenin beta-1.	Low-density lipoprotein receptor-related protein 6.	0.686
Ctnnb1	Myc	G3H996	G3IP28	Catenin beta-1.	Myc proto-oncogene protein.	0.673
Ctnnb1	Smo	G3H996	G3GZ55	Catenin beta-1.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.460
Ctnnb1	Tgfbr2	G3H996	G3GV87	Catenin beta-1.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.597
Ctnnb1	Wnt11	G3H996	G3HUR9	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.608
Ctnnb1	Wnt2	G3H996	G3H9J2	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.684
Ctnnb1	Wnt5a	G3H996	G3GUT6	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.628
Ctnnb1	Zeb1	G3H996	G3HN44	Catenin beta-1.	Zinc finger E-box-binding homeobox 1.	0.580
Ctnnbip1	Ctnnb1	G3IKH6	G3H996	Beta-catenin-interacting protein 1.	Catenin beta-1.	0.999
Fgfr2	Ctnnb1	G3IJY0	G3H996	Fibroblast growth factor receptor 2.	Catenin beta-1.	0.527