STRINGSTRING
Alx1 Alx1 Bambi Bambi Smad4 Smad4 I79_015109 I79_015109 Wwtr1 Wwtr1 Fermt2 Fermt2 Ager Ager Tbx20 Tbx20 I79_017833 I79_017833 IL1B IL1B I79_016423 I79_016423 Tgfb1 Tgfb1 I79_020783 I79_020783 Glipr2 Glipr2 Mtor Mtor Tcf7l2 Tcf7l2 Olfm1 Olfm1 Pdpn Pdpn CgPICR_015515 CgPICR_015515 Bcl9l Bcl9l I79_000092 I79_000092 Jag1 Jag1 Loxl2 Loxl2 Tgfbr2 Tgfbr2 Emp2 Emp2 Ezh2 Ezh2 Mdk Mdk I79_003100 I79_003100 Znf703 Znf703 I79_006254 I79_006254 Tgfbr1 Tgfbr1 Axin2 Axin2 Smad3 Smad3 Ctnnb1 Ctnnb1 Smad2 Smad2 Bmp7 Bmp7 I79_008174 I79_008174 Sdcbp Sdcbp Snai1 Snai1 I79_009361 I79_009361 I79_009362 I79_009362 Tgfb3 Tgfb3 Rgcc Rgcc I79_009834 I79_009834 Acvr1 Acvr1 Hdac2 Hdac2 Col1a1 Col1a1 I79_011565 I79_011565
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Alx1ALX homeobox protein 1. (295 aa)
BambiBMP and activin membrane-bound inhibitor-like. (218 aa)
Smad4Mothers against decapentaplegic-like 4. (259 aa)
I79_015109Interleukin-6. (174 aa)
Wwtr1WW domain-containing transcription regulator protein 1. (395 aa)
Fermt2Fermitin family-like 2. (575 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
Tbx20T-box transcription factor TBX20. (445 aa)
I79_017833Lymphoid enhancer-binding factor 1. (276 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
I79_020783Transcription factor 7-like 2. (451 aa)
Glipr2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (117 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Tcf7l2Transcription factor 7-like 1. (73 aa)
Olfm1Noelin. (457 aa)
PdpnPodoplanin. (55 aa)
CgPICR_015515N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase. (311 aa)
Bcl9lB-cell CLL/lymphoma 9-like protein. (1497 aa)
I79_000092Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
Jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1186 aa)
Loxl2Lysyl oxidase-like 2. (300 aa)
Tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Emp2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (174 aa)
Ezh2Histone-lysine N-methyltransferase EZH2. (746 aa)
MdkMidkine. (160 aa)
I79_003100Myocardin. (371 aa)
Znf703Zinc finger protein 703. (143 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
Tgfbr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (401 aa)
Axin2Axin-2. (809 aa)
Smad3Mothers against decapentaplegic homolog. (363 aa)
Ctnnb1Catenin beta-1. (781 aa)
Smad2Mothers against decapentaplegic homolog. (467 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
I79_008174Leucine-rich alpha-2-glycoprotein. (117 aa)
SdcbpSyntenin-1. (298 aa)
Snai1Zinc finger protein SNAI1-like protein. (264 aa)
I79_009361N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase. (344 aa)
I79_009362N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase. (228 aa)
Tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
RgccResponse gene to complement 32 protein. (153 aa)
I79_009834Disabled-like 2. (705 aa)
Acvr1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
Hdac2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (458 aa)
Col1a1Collagen alpha-1(I) chain. (355 aa)
I79_011565Crumbs-like 2. (1065 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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