STRINGSTRING
Rnf10 Rnf10 Dusp10 Dusp10 Prox1 Prox1 I79_000155 I79_000155 I79_000156 I79_000156 Wnt7a Wnt7a Rgma Rgma I79_000669 I79_000669 I79_000700 I79_000700 I79_001046 I79_001046 Tmem98 Tmem98 I79_001073 I79_001073 Cit Cit Dlx1 Dlx1 Dlx2 Dlx2 Wnt5a Wnt5a I79_001486 I79_001486 I79_001738 I79_001738 Ulk2 Ulk2 Rnf6 Rnf6 I79_002496 I79_002496 I79_002659 I79_002659 I79_002693 I79_002693 Kctd11 Kctd11 F2 F2 Pax6 Pax6 I79_003174 I79_003174 Actr3 Actr3 Tnr Tnr Brinp1 Brinp1 I79_003408 I79_003408 I79_003549 I79_003549 B2m B2m Cav3 Cav3 I79_003898 I79_003898 H671_3g8832 H671_3g8832 Nog Nog Sema4c Sema4c I79_004333 I79_004333 Cdkl3 Cdkl3 Cers2 Cers2 Sema6c Sema6c Gpr37l1 Gpr37l1 I79_004859 I79_004859 Bcl11a Bcl11a Map2 Map2 Igf1 Igf1 Nodal Nodal I79_006254 I79_006254 Shb Shb Sema5a Sema5a Ifrd2 Ifrd2 Sema3b Sema3b Sema3f Sema3f I79_006675 I79_006675 Ctnnb1 Ctnnb1 I79_007067 I79_007067 Ptn Ptn Gsk3b Gsk3b Fgf13 Fgf13 Cdk5 Cdk5 I79_007709 I79_007709 Bmp7 Bmp7 Tsc2 Tsc2 Trim46 Trim46 Ulk1 Ulk1 Sema6b Sema6b Ptprs Ptprs I79_008197 I79_008197 Fbxw9 Fbxw9 I79_008405 I79_008405 I79_008527 I79_008527 Tdp2 Tdp2 Ifrd1 Ifrd1 Id1 Id1 Sema7a Sema7a Spry4 Spry4 Cldn18 Cldn18 Kdm4a Kdm4a I79_009343 I79_009343 Sema4a Sema4a Arhgef2 Arhgef2 H671_1g1417 H671_1g1417 Wee2 Wee2 I79_010127 I79_010127 I79_010136 I79_010136 I79_010290 I79_010290 Coro1c Coro1c H671_3g8622 H671_3g8622 S1pr3 S1pr3 I79_010470 I79_010470 Ephb2 Ephb2 Kdm1a Kdm1a I79_010752 I79_010752 Actn4 Actn4 Sirt2 Sirt2 I79_010785 I79_010785 I79_010923 I79_010923 Rtn4 Rtn4 Fgfr3 Fgfr3 Ywhah Ywhah I79_011500 I79_011500 I79_011501 I79_011501 I79_011789 I79_011789 I79_011934 I79_011934 I79_011935 I79_011935 I79_011943 I79_011943 Sema3c Sema3c Rapgef2 Rapgef2 Npr2 Npr2 Sema3a Sema3a Sema3e Sema3e Psen1 Psen1 I79_012498 I79_012498 Sema6a Sema6a I79_012610 I79_012610 I79_012741 I79_012741 I79_013004 I79_013004 I79_013088 I79_013088 Gorasp1 Gorasp1 H671_3g9857 H671_3g9857 Fas Fas Rb1 Rb1 I79_013556 I79_013556 Sema3d Sema3d Grb14 Grb14 Mecp2 Mecp2 I79_013961 I79_013961 Trak2 Trak2 I79_015046 I79_015046 H671_3g10913 H671_3g10913 Dynlt1 Dynlt1 I79_015458 I79_015458 I79_015503 I79_015503 Rflna Rflna Dip2b Dip2b Ttc3 Ttc3 Tspo Tspo I79_015873 I79_015873 Ascl2 Ascl2 Dnajb11 Dnajb11 Nrp1 Nrp1 Dicer1 Dicer1 I79_016547 I79_016547 Ttpal Ttpal IL1B IL1B I79_017352 I79_017352 Ski Ski I79_017935 I79_017935 Rufy3 Rufy3 I79_018312 I79_018312 Tbx6 Tbx6 Bcar1 Bcar1 Sox10 Sox10 I79_018586 I79_018586 Adcyap1 Adcyap1 Mbp Mbp Nr1d1 Nr1d1 I79_018913 I79_018913 Tacstd2 Tacstd2 Syt4 Syt4 I79_019236 I79_019236 Atf5 Atf5 Ptk2 Ptk2 Sema4f Sema4f I79_019878 I79_019878 Lhx2 Lhx2 Rest Rest Tgfb1 Tgfb1 Pthlh Pthlh H671_1g3307 H671_1g3307 Gdi1 Gdi1 Plxna3 Plxna3 I79_021038 I79_021038 Wnt7b Wnt7b I79_021577 I79_021577 Postn Postn I79_021789 I79_021789 Efna5 Efna5 I79_022157 I79_022157 I79_022515 I79_022515 I79_022667 I79_022667 Fbln1 Fbln1 Idh2 Idh2 Itgb1bp1 Itgb1bp1 Sema4b Sema4b Ntrk3 Ntrk3 I79_023475 I79_023475 Thy1 Thy1 Mfn2 Mfn2 Kank1 Kank1 Sema4g Sema4g I79_023921 I79_023921 I79_023937 I79_023937 Rcc2 Rcc2 I79_024271 I79_024271 I79_024593 I79_024593 I79_025142 I79_025142 Nppc Nppc I79_025170 I79_025170 I79_025320 I79_025320 I79_025360 I79_025360 I79_025481 I79_025481 I79_025558 I79_025558 Sorl1 Sorl1 I79_025719 I79_025719 I79_025745 I79_025745 I79_026075 I79_026075 LDLR LDLR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rnf10RING finger protein 10. (759 aa)
Dusp10Dual specificity protein phosphatase 10. (482 aa)
Prox1Prospero homeobox protein 1. (738 aa)
I79_000155Protogenin. (508 aa)
I79_000156Protogenin. (703 aa)
Wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (282 aa)
RgmaRepulsive guidance molecule A. (414 aa)
I79_000669Semaphorin-5B. (979 aa)
I79_000700Receptor protein-tyrosine kinase. (871 aa)
I79_001046Neurofibromin. (2164 aa)
Tmem98Transmembrane protein 98. (226 aa)
I79_001073C-C motif chemokine. (72 aa)
CitCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2056 aa)
Dlx1Homeobox protein DLX-1. (255 aa)
Dlx2Homeobox protein DLX-2. (347 aa)
Wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
I79_001486Short transient receptor potential channel 6; Belongs to the transient receptor (TC 1.A.4) family. (877 aa)
I79_001738Serine/threonine-protein kinase ULK2. (112 aa)
Ulk2Serine/threonine-protein kinase ULK2. (830 aa)
Rnf6E3 ubiquitin-protein ligase. (666 aa)
I79_002496Nuclear receptor subfamily 2 group E member 1. (323 aa)
I79_002659High mobility group protein HMGI-C. (103 aa)
I79_002693Netrin-1. (252 aa)
Kctd11BTB/POZ domain-containing protein KCTD11. (232 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
Pax6Paired box protein Pax-6. (544 aa)
I79_003174Pericentriolar material 1 protein. (1960 aa)
Actr3Actin-related protein 3; Belongs to the actin family. (418 aa)
TnrTenascin-R. (1358 aa)
Brinp1Deleted in bladder cancer protein 1-like. (716 aa)
I79_003408Slit-like 1 protein. (1482 aa)
I79_003549D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
B2mBeta-2-microglobulin. (54 aa)
Cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
I79_003898RING finger protein 6. (477 aa)
H671_3g8832E3 ubiquitin-protein ligase. (169 aa)
NogNoggin. (117 aa)
Sema4cSemaphorin-4C; Belongs to the semaphorin family. (834 aa)
I79_004333Follistatin-related protein 4. (647 aa)
Cdkl3Cyclin-dependent kinase-like 3. (456 aa)
Cers2LAG1 longevity assurance-like 2 protein. (380 aa)
Sema6cSemaphorin-6C; Belongs to the semaphorin family. (331 aa)
Gpr37l1Endothelin B receptor-like protein 2. (481 aa)
I79_004859Protein atonal-like 1. (293 aa)
Bcl11aB-cell lymphoma/leukemia 11A. (749 aa)
Map2Microtubule-associated protein. (1608 aa)
Igf1Insulin-like growth factor I. (75 aa)
NodalNodal. (309 aa)
I79_006254Bone morphogenetic protein 4. (406 aa)
ShbSH2 domain-containing adapter protein B. (298 aa)
Sema5aSemaphorin-5A. (1046 aa)
Ifrd2Interferon-related developmental regulator 2. (64 aa)
Sema3bSemaphorin-3B; Belongs to the semaphorin family. (749 aa)
Sema3fSemaphorin-3F; Belongs to the semaphorin family. (785 aa)
I79_006675Secreted frizzled-related protein 3. (286 aa)
Ctnnb1Catenin beta-1. (781 aa)
I79_007067Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1107 aa)
PtnPleiotrophin. (168 aa)
Gsk3bGlycogen synthase kinase-3 beta. (328 aa)
Fgf13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (117 aa)
Cdk5Cell division protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
I79_007709SCO-spondin. (353 aa)
Bmp7Bone morphogenetic protein 7. (430 aa)
Tsc2Tuberin. (1546 aa)
Trim46Tripartite motif-containing protein 46. (522 aa)
Ulk1Serine/threonine-protein kinase ULK1. (999 aa)
Sema6bSemaphorin-6B; Belongs to the semaphorin family. (823 aa)
PtprsReceptor-type tyrosine-protein phosphatase S. (889 aa)
I79_008197Receptor-type tyrosine-protein phosphatase S. (515 aa)
Fbxw9F-box/WD repeat-containing protein 9. (458 aa)
I79_008405Tyrosine-protein kinase RYK. (141 aa)
I79_008527Nuclear factor of activated T-cells, cytoplasmic 4. (849 aa)
Tdp2Uncharacterized protein KIAA0319. (1024 aa)
Ifrd1Interferon-related developmental regulator 1. (401 aa)
Id1DNA-binding protein inhibitor ID-1. (157 aa)
Sema7aSemaphorin-7A; Belongs to the semaphorin family. (560 aa)
Spry4Protein sprouty-like 4. (100 aa)
Cldn18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
Kdm4aLysine-specific demethylase 4A. (576 aa)
I79_009343N-myc proto-oncogene protein. (316 aa)
Sema4aSemaphorin-4A; Belongs to the semaphorin family. (761 aa)
Arhgef2Rho guanine nucleotide exchange factor 2. (1031 aa)
H671_1g1417Spartin isoform 2. (616 aa)
Wee2Wee1-like protein kinase 2. (249 aa)
I79_010127Tripartite motif-containing protein 11. (548 aa)
I79_010136Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (230 aa)
I79_010290Endothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
Coro1cCoronin; Belongs to the WD repeat coronin family. (474 aa)
H671_3g8622Semaphorin-4D; Belongs to the semaphorin family. (833 aa)
S1pr3Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
I79_010470Metallothionein-3; Belongs to the metallothionein superfamily. Type 1 family. (108 aa)
Ephb2Ephrin type-B receptor 2. (1018 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
I79_010752Alpha-actinin-4. (327 aa)
Actn4Alpha-actinin-4. (234 aa)
Sirt2NAD-dependent deacetylase sirtuin-2. (83 aa)
I79_010785Delta-like protein 3. (388 aa)
I79_010923Reticulon. (68 aa)
Rtn4Reticulon-4. (806 aa)
Fgfr3Fibroblast growth factor receptor 3. (319 aa)
Ywhah14-3-3 protein eta; Belongs to the 14-3-3 family. (236 aa)
I79_011500Deleted in bladder cancer protein 1-like. (243 aa)
I79_011501Deleted in bladder cancer protein 1-like. (214 aa)
I79_011789DNA-binding protein inhibitor ID-2. (185 aa)
I79_011934Semaphorin-6D. (150 aa)
I79_011935Semaphorin-6D; Belongs to the semaphorin family. (780 aa)
I79_011943Semaphorin-3C. (86 aa)
Sema3cSemaphorin-3C; Belongs to the semaphorin family. (493 aa)
Rapgef2Uncharacterized protein. (524 aa)
Npr2Guanylate cyclase. (663 aa)
Sema3aSemaphorin-3A-like protein; Belongs to the semaphorin family. (758 aa)
Sema3eSemaphorin-3E; Belongs to the semaphorin family. (777 aa)
Psen1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
I79_012498Semaphorin-6A. (305 aa)
Sema6aSemaphorin-6A; Belongs to the semaphorin family. (503 aa)
I79_012610Short transient receptor potential channel 5; Belongs to the transient receptor (TC 1.A.4) family. (865 aa)
I79_012741Kinesin-associated protein 3. (610 aa)
I79_013004F-box/WD repeat-containing protein 7. (709 aa)
I79_013088Methyl-CpG-binding domain protein 1. (330 aa)
Gorasp1Golgi reassembly-stacking protein 1. (441 aa)
H671_3g9857Tumor necrosis factor receptor superfamily member 6-like protein. (170 aa)
FasTumor necrosis factor receptor superfamily member 6. (124 aa)
Rb1Retinoblastoma-associated protein. (302 aa)
I79_013556Fibrillin-1. (2698 aa)
Sema3dSemaphorin-3D; Belongs to the semaphorin family. (759 aa)
Grb14Growth factor receptor-bound protein 14. (466 aa)
Mecp2Methyl-CpG-binding protein 2. (203 aa)
I79_013961Rho GTPase-activating protein 4. (958 aa)
Trak2Trafficking kinesin-binding protein 2. (913 aa)
I79_015046Low-density lipoprotein receptor. (160 aa)
H671_3g10913Protein sprouty-like 4. (82 aa)
Dynlt1Dynein light chain Tctex-type 1. (90 aa)
I79_015458C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (337 aa)
I79_015503Transcription factor HES-1. (92 aa)
RflnaProtein FAM101A. (210 aa)
Dip2bDisco-interacting protein 2-like B. (957 aa)
Ttc3Tetratricopeptide repeat protein 3. (1499 aa)
TspoTranslocator protein. (169 aa)
I79_015873Pituitary homeobox 3. (214 aa)
Ascl2Achaete-scute-like 2. (193 aa)
Dnajb11DnaJ-like subfamily B member 11. (359 aa)
Nrp1Neuropilin; Belongs to the neuropilin family. (923 aa)
Dicer1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
I79_016547DCC-interacting protein 13-beta. (634 aa)
TtpalAlpha-tocopherol transfer protein-like. (343 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
I79_017352ATP-binding cassette transporter sub-family C member 8. (2352 aa)
SkiSki oncogene. (636 aa)
I79_017935Lin-28-like A. (169 aa)
Rufy3Protein RUFY3. (542 aa)
I79_018312Tyrosine-protein kinase RYK. (163 aa)
Tbx6T-box transcription factor TBX6-like isoform 1. (436 aa)
Bcar1Breast cancer anti-estrogen resistance protein 1. (879 aa)
Sox10Transcription factor SOX-10. (466 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
Adcyap1Pituitary adenylate cyclase-activating polypeptide-like protein. (176 aa)
MbpMyelin basic protein. (243 aa)
Nr1d1Nuclear receptor subfamily 1 group D member 1. (508 aa)
I79_018913Homeobox protein Nkx-6.2. (114 aa)
Tacstd2Tumor-associated calcium signal transducer 2-like protein. (318 aa)
Syt4Synaptotagmin-4. (243 aa)
I79_019236Ras GTPase-activating protein SynGAP. (152 aa)
Atf5Cyclic AMP-dependent transcription factor ATF-5. (279 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
Sema4fSemaphorin-4F; Belongs to the semaphorin family. (751 aa)
I79_019878Sortilin. (1038 aa)
Lhx2LIM/homeobox protein Lhx2. (385 aa)
RestRE1-silencing transcription factor. (1047 aa)
Tgfb1Transforming growth factor beta-1. (237 aa)
PthlhParathyroid hormone-related protein. (191 aa)
H671_1g3307Disheveled-associated activator of morphogenesis 2. (967 aa)
Gdi1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (425 aa)
Plxna3Plexin-A3. (656 aa)
I79_021038Plexin-A3. (334 aa)
Wnt7bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
I79_021577Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
PostnPeriostin isoform 6. (785 aa)
I79_021789NT-3 growth factor receptor. (389 aa)
Efna5Ephrin-A5; Belongs to the ephrin family. (172 aa)
I79_022157Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (354 aa)
I79_022515Serine/threonine-protein phosphatase. (325 aa)
I79_022667Fibulin-1. (628 aa)
Fbln1Fibulin-1. (156 aa)
Idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
Itgb1bp1Integrin beta-1-binding protein 1. (199 aa)
Sema4bSemaphorin-4B; Belongs to the semaphorin family. (792 aa)
Ntrk3Tyrosine-protein kinase receptor. (226 aa)
I79_023475Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform. (81 aa)
Thy1Thy-1 membrane glycoprotein. (147 aa)
Mfn2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
Kank1KN motif and ankyrin repeat domain-containing protein 1. (1359 aa)
Sema4gSemaphorin-4G; Belongs to the semaphorin family. (757 aa)
I79_023921Trichosurin; Belongs to the calycin superfamily. Lipocalin family. (212 aa)
I79_023937Sortilin-related receptor. (88 aa)
Rcc2Protein RCC2. (292 aa)
I79_024271NT-3 growth factor receptor. (114 aa)
I79_024593Uncharacterized protein. (194 aa)
I79_025142Tight junction protein ZO-2. (464 aa)
NppcC-type natriuretic peptide. (126 aa)
I79_025170Slit-like 2 protein. (345 aa)
I79_025320Draxin. (56 aa)
I79_025360Draxin. (262 aa)
I79_025481Tight junction protein ZO-2. (294 aa)
I79_025558Gamma1-adaptin brefeldin A resistance protein. (111 aa)
Sorl1Sortilin-related receptor. (223 aa)
I79_025719Tight junction protein ZO-2. (190 aa)
I79_025745Nuclear receptor subfamily 1 group D member 1. (226 aa)
I79_026075Isocitrate dehydrogenase [NADP], mitochondrial. (123 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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