node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gsk3a | Myc | G3I0M4 | G3IP28 | Glycogen synthase kinase-3 alpha. | Myc proto-oncogene protein. | 0.447 |
I79_016547 | Pea15 | G3HZP0 | G3H7Y4 | DCC-interacting protein 13-beta. | Astrocytic phosphoprotein PEA-15. | 0.728 |
I79_017273 | Prkca | G3I1L0 | G3HCR5 | Protein kinase C alpha type. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.622 |
I79_017273 | Stxbp3 | G3I1L0 | G3IK27 | Protein kinase C alpha type. | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | 0.450 |
IL1B | Lep | G3I1B0 | G3GZ86 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.620 |
IL1B | Tnf | G3I1B0 | G3HZG9 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.914 |
Lep | IL1B | G3GZ86 | G3I1B0 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.620 |
Lep | Tnf | G3GZ86 | G3HZG9 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.633 |
Myc | Gsk3a | G3IP28 | G3I0M4 | Myc proto-oncogene protein. | Glycogen synthase kinase-3 alpha. | 0.447 |
Pea15 | I79_016547 | G3H7Y4 | G3HZP0 | Astrocytic phosphoprotein PEA-15. | DCC-interacting protein 13-beta. | 0.728 |
Prkca | I79_017273 | G3HCR5 | G3I1L0 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein kinase C alpha type. | 0.622 |
Prkca | Prkcb | G3HCR5 | G3I989 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase. | 0.902 |
Prkca | Stxbp3 | G3HCR5 | G3IK27 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | 0.450 |
Prkcb | Prkca | G3I989 | G3HCR5 | Non-specific serine/threonine protein kinase. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.902 |
Prkcb | Stxbp3 | G3I989 | G3IK27 | Non-specific serine/threonine protein kinase. | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | 0.450 |
Stxbp3 | I79_017273 | G3IK27 | G3I1L0 | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | Protein kinase C alpha type. | 0.450 |
Stxbp3 | Prkca | G3IK27 | G3HCR5 | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.450 |
Stxbp3 | Prkcb | G3IK27 | G3I989 | Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. | Non-specific serine/threonine protein kinase. | 0.450 |
Tnf | IL1B | G3HZG9 | G3I1B0 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. | 0.914 |
Tnf | Lep | G3HZG9 | G3GZ86 | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.633 |