(30 nodes) Astrocyte development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_010470	Metallothionein-3; Belongs to the metallothionein superfamily. Type 1 family. (108 aa)
	I79_010799	Tetraspanin-2; Belongs to the tetraspanin (TM4SF) family. (155 aa)
	Grn	Granulins. (592 aa)
	Gfap	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (427 aa)
	App	Amyloid beta A4 protein. (433 aa)
	Psen1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	Dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (741 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Adora2a	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (408 aa)
	I79_016051	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (777 aa)
	Ager	Advanced glycosylation end product-specific receptor. (334 aa)
	I79_016423	Advanced glycosylation end product-specific receptor. (65 aa)
	Tlr4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Ifngr1	Interferon-gamma receptor alpha chain. (471 aa)
	Agt	Angiotensinogen; Belongs to the serpin family. (477 aa)
	Smo	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
	Ror1	Tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (874 aa)
	Drd1	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	I79_008941	Receptor protein-tyrosine kinase. (962 aa)
	I79_009291	Beta-secretase 2; Belongs to the peptidase A1 family. (378 aa)
	Vim	Vimentin; Belongs to the intermediate filament family. (466 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
	Eif2b5	Translation initiation factor eIF-2B subunit epsilon. (716 aa)
	I79_019770	Protein S100; Belongs to the S-100 family. (124 aa)
	H671_xg20009	Myelin proteolipid protein. (276 aa)
	Lamb2	Laminin subunit beta-2. (1800 aa)
	I79_021773	Laminin subunit gamma-3. (403 aa)
	Cntf	Ciliary neurotrophic factor. (59 aa)
	Lamc3	Laminin subunit gamma-3. (342 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ager	App	G3HZC3	G3HMG4	Advanced glycosylation end product-specific receptor.	Amyloid beta A4 protein.	0.589
Ager	I79_019770	G3HZC3	G3I8A7	Advanced glycosylation end product-specific receptor.	Protein S100; Belongs to the S-100 family.	0.517
Agt	App	G3GX14	G3HMG4	Angiotensinogen; Belongs to the serpin family.	Amyloid beta A4 protein.	0.456
Agt	Tlr4	G3GX14	G3I192	Angiotensinogen; Belongs to the serpin family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.440
App	Ager	G3HMG4	G3HZC3	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.589
App	Agt	G3HMG4	G3GX14	Amyloid beta A4 protein.	Angiotensinogen; Belongs to the serpin family.	0.456
App	Gfap	G3HMG4	G3HLL7	Amyloid beta A4 protein.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.596
App	I79_008941	G3HMG4	G3HEF7	Amyloid beta A4 protein.	Receptor protein-tyrosine kinase.	0.493
App	I79_009291	G3HMG4	G3HFD5	Amyloid beta A4 protein.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.779
App	I79_016423	G3HMG4	G3HZC4	Amyloid beta A4 protein.	Advanced glycosylation end product-specific receptor.	0.511
App	IL1B	G3HMG4	G3I1B0	Amyloid beta A4 protein.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.487
App	Lrp1	G3HMG4	G3HW34	Amyloid beta A4 protein.	Prolow-density lipoprotein receptor-related protein 1.	0.648
App	Psen1	G3HMG4	G3HNF2	Amyloid beta A4 protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.971
Cntf	Gfap	G3IIP9	G3HLL7	Ciliary neurotrophic factor.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.554
Cntf	Ifngr1	G3IIP9	G3GW63	Ciliary neurotrophic factor.	Interferon-gamma receptor alpha chain.	0.687
Cntf	Smo	G3IIP9	G3GZ55	Ciliary neurotrophic factor.	Smoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family.	0.484
Dll1	Psen1	G3HNT7	G3HNF2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.481
Gfap	App	G3HLL7	G3HMG4	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Amyloid beta A4 protein.	0.596
Gfap	Cntf	G3HLL7	G3IIP9	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Ciliary neurotrophic factor.	0.554
Gfap	H671_xg20009	G3HLL7	G3IAL1	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	Myelin proteolipid protein.	0.537