(37 nodes) Phosphatidylinositol 3-kinase signaling network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Sirt2	NAD-dependent deacetylase sirtuin-2. (83 aa)
	I79_001046	Neurofibromin. (2164 aa)
	C1qbp	Complement component 1 Q subcomponent-binding protein, mitochondrial. (209 aa)
	I79_003052	Protor-2. (391 aa)
	Edn1	Endothelin-1. (202 aa)
	I79_003820	Tyrosine-protein kinase receptor. (607 aa)
	Zfp36l1	Butyrate response factor 1. (338 aa)
	I79_004486	CD160 antigen. (151 aa)
	Akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	I79_005111	Phosphatidylinositol 3-kinase regulatory subunit beta. (653 aa)
	Pik3r1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (726 aa)
	Igf1	Insulin-like growth factor I. (75 aa)
	Tsc2	Tuberin. (1546 aa)
	I79_009115	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (441 aa)
	I79_009116	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (311 aa)
	I79_009584	Platelet endothelial aggregation receptor 1. (821 aa)
	I79_001030	Myosin-XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1503 aa)
	Gata3	Trans-acting T-cell-specific transcription factor GATA-3. (443 aa)
	I79_010083	Putative tyrosine-protein phosphatase TPTE. (212 aa)
	Pik3c2a	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide; Belongs to the PI3/PI4-kinase family. (637 aa)
	Kbtbd2	Kelch repeat and BTB domain-containing protein 2. (623 aa)
	Pik3c2b	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide; Belongs to the PI3/PI4-kinase family. (1633 aa)
	Ikzf4	Receptor protein-tyrosine kinase. (1902 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	Pik3c2g	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; Belongs to the PI3/PI4-kinase family. (493 aa)
	Pik3ca	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (86 aa)
	Serpina12	Serpin A12; Belongs to the serpin family. (414 aa)
	I79_018131	5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
	Htr2a	5-hydroxytryptamine receptor 2A. (264 aa)
	I79_018586	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
	I79_018966	Uncharacterized protein C7orf51-like. (628 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (910 aa)
	H671_5g14804	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1012 aa)
	I79_021668	Uncharacterized protein KIAA1486. (682 aa)
	Irs1	Insulin receptor substrate 1. (1233 aa)
	Prr5	Protor-1. (343 aa)
	I79_024744	5-hydroxytryptamine receptor 2B. (407 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Akt1	Edn1	G3H397	G3H0G9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Endothelin-1.	0.412
Akt1	H671_5g14804	G3H397	G3I9B2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.755
Akt1	I79_005111	G3H397	G3H4B1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.585
Akt1	I79_009115	G3H397	G3HEW7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.644
Akt1	I79_009116	G3H397	G3HEW9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.644
Akt1	I79_010083	G3H397	G3HHJ6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Putative tyrosine-protein phosphatase TPTE.	0.616
Akt1	I79_018586	G3H397	G3I540	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN.	0.767
Akt1	Igf1	G3H397	G3H672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I.	0.710
Akt1	Ikzf4	G3H397	G3HRK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.514
Akt1	Irs1	G3H397	G3IDC4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.724
Akt1	Pik3ca	G3H397	G3I1C5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family.	0.985
Akt1	Pik3cd	G3H397	G3I7G5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.961
Akt1	Pik3r1	G3H397	G3H4N4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.974
Akt1	Tsc2	G3H397	G3HBQ8	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tuberin.	0.976
Akt1	Zfp36l1	G3H397	G3H1L0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Butyrate response factor 1.	0.531
Edn1	Akt1	G3H0G9	G3H397	Endothelin-1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.412
Edn1	I79_003820	G3H0G9	G3H100	Endothelin-1.	Tyrosine-protein kinase receptor.	0.408
H671_5g14804	Akt1	G3I9B2	G3H397	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.755
H671_5g14804	I79_003820	G3I9B2	G3H100	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Tyrosine-protein kinase receptor.	0.444
H671_5g14804	I79_005111	G3I9B2	G3H4B1	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.894