(30 nodes) Striated muscle cell proliferation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I79_025459	Mothers against decapentaplegic-like 1. (117 aa)
	I79_000092	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Tbx5	T-box transcription factor TBX5. (518 aa)
	Jarid2	Protein Jumonji. (1221 aa)
	I79_003941	Multiple epidermal growth factor-like domains 10. (800 aa)
	Cxadr	Coxsackievirus and adenovirus receptor-like. (394 aa)
	I79_006225	Sonic hedgehog protein. (226 aa)
	Prkar1a	cAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
	Smad1	Mothers against decapentaplegic-like 1. (232 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	Wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (321 aa)
	I79_007135	Homeobox protein Nkx-2.5. (223 aa)
	Tgfbr3	TGF-beta receptor type III. (849 aa)
	Bmp10	Bone morphogenetic protein 10. (399 aa)
	Hgf	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
	Rxrb	Retinoic acid receptor RXR-beta. (101 aa)
	Rtl5	Retrotransposon gag domain-containing protein 4. (197 aa)
	I79_017749	Mitogen-activated protein kinase 11. (413 aa)
	Rtl1	Retrotransposon-like protein 1. (634 aa)
	I79_019031	Teneurin-4. (3477 aa)
	Arid2	AT-rich interactive domain-containing protein 2. (1284 aa)
	Hey2	Hairy/enhancer-of-split related with YRPW motif protein 2. (276 aa)
	Sav1	Protein salvador-like 1. (210 aa)
	Rxra	Retinoic acid receptor RXR-alpha. (439 aa)
	I79_021938	Mothers against decapentaplegic-like 1. (122 aa)
	I79_024248	Importin subunit alpha; Functions in nuclear protein import. (538 aa)
	I79_024959	Mothers against decapentaplegic-like 1. (161 aa)
	I79_025316	Mothers against decapentaplegic-like 1. (104 aa)
	I79_025783	Mothers against decapentaplegic-like 1. (97 aa)
	I79_025513	Mothers against decapentaplegic-like 1. (151 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp10	I79_007135	G3HIB8	G3H9Q5	Bone morphogenetic protein 10.	Homeobox protein Nkx-2.5.	0.410
Hey2	Jarid2	G3IB43	G3GUE6	Hairy/enhancer-of-split related with YRPW motif protein 2.	Protein Jumonji.	0.449
Hey2	Tbx5	G3IB43	G3GU42	Hairy/enhancer-of-split related with YRPW motif protein 2.	T-box transcription factor TBX5.	0.461
Hgf	Wnt2	G3HPQ5	G3H9J2	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
I79_000092	Tgfbr3	G3GRE7	G3HEB6	Transforming growth factor beta; Belongs to the TGF-beta family.	TGF-beta receptor type III.	0.707
I79_006225	Wnt2	G3H796	G3H9J2	Sonic hedgehog protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.598
I79_007135	Bmp10	G3H9Q5	G3HIB8	Homeobox protein Nkx-2.5.	Bone morphogenetic protein 10.	0.410
I79_007135	Tbx5	G3H9Q5	G3GU42	Homeobox protein Nkx-2.5.	T-box transcription factor TBX5.	0.955
I79_021938	I79_025316	G3IDZ7	G3IN07	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.638
I79_021938	I79_025459	G3IDZ7	G3INE2	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.893
I79_021938	I79_025783	G3IDZ7	G3IP79	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.563
I79_024959	I79_025316	G3IM29	G3IN07	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.611
I79_024959	I79_025459	G3IM29	G3INE2	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.900
I79_024959	I79_025783	G3IM29	G3IP79	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.545
I79_025316	I79_021938	G3IN07	G3IDZ7	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.638
I79_025316	I79_024959	G3IN07	G3IM29	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.611
I79_025316	I79_025459	G3IN07	G3INE2	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.764
I79_025316	I79_025513	G3IN07	G3INI8	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.627
I79_025459	I79_021938	G3INE2	G3IDZ7	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.893
I79_025459	I79_024959	G3INE2	G3IM29	Mothers against decapentaplegic-like 1.	Mothers against decapentaplegic-like 1.	0.900