STRINGSTRING
Crk Crk Pdgfd Pdgfd Hdac4 Hdac4 Ager Ager I79_016423 I79_016423 Aif1 Aif1 Tlr4 Tlr4 Pdgfb Pdgfb Drd4 Drd4 Adamts1 Adamts1 Coro1b Coro1b Ptk2 Ptk2 Foxo4 Foxo4 Ccl5 Ccl5 I79_019878 I79_019878 I79_020258 I79_020258 Nox4 Nox4 Abhd2 Abhd2 Postn Postn H671_2g5523 H671_2g5523 Arpc2 Arpc2 I79_022301 I79_022301 I79_022305 I79_022305 Iqgap1 Iqgap1 P2ry6 P2ry6 I79_023125 I79_023125 I79_023816 I79_023816 I79_023937 I79_023937 I79_024415 I79_024415 I79_024593 I79_024593 I79_024807 I79_024807 Pak1 Pak1 P2ry2 P2ry2 I79_025170 I79_025170 I79_025454 I79_025454 I79_025549 I79_025549 Sorl1 Sorl1 Trib1 Trib1 Myc Myc I79_025798 I79_025798 Has2 Has2 Tert Tert I79_000300 I79_000300 I79_000133 I79_000133 ilk ilk Cav1 Cav1 Serpine1 Serpine1 I79_007297 I79_007297 Mef2c Mef2c Egr1 Egr1 Itgb3 Itgb3 I79_010073 I79_010073 Il6st Il6st Ssh1 Ssh1 Rps6kb1 Rps6kb1 I79_011934 I79_011934 I79_011935 I79_011935 Atp7a Atp7a Ddr2 Ddr2 I79_013437 I79_013437 Ppard Ppard I79_013660 I79_013660 Pdgfrb Pdgfrb I79_013999 I79_013999 Adipoq Adipoq Lpar1 Lpar1 PPARG PPARG Lrp1 Lrp1 Ppargc1a Ppargc1a I79_006679 I79_006679 Gna13 Gna13 APE APE I79_026218 I79_026218 I79_025994 I79_025994 I79_025944 I79_025944 I79_006462 I79_006462 MED4 MED4 S1pr2 S1pr2 Igf1 Igf1 Fga Fga I79_005379 I79_005379 Igfbp5 Igfbp5 Il18 Il18 Nfe2l2 Nfe2l2 Tacr1 Tacr1 Dock7 Dock7 Smo Smo I79_003100 I79_003100 Mdk Mdk Src Src Agt Agt I79_002178 I79_002178 Gna12 Gna12 Pde4d Pde4d Dock5 Dock5 I79_001487 I79_001487 I79_001274 I79_001274 I79_001046 I79_001046 Vtn Vtn Plxna1 Plxna1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CrkProto-oncogene C-crk. (327 aa)
PdgfdPlatelet-derived growth factor D. (253 aa)
Hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (966 aa)
AgerAdvanced glycosylation end product-specific receptor. (334 aa)
I79_016423Advanced glycosylation end product-specific receptor. (65 aa)
Aif1Allograft inflammatory factor 1. (80 aa)
Tlr4Toll-like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
PdgfbPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (205 aa)
Drd4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
Adamts1A disintegrin and metalloproteinase with thrombospondin motifs 1. (705 aa)
Coro1bCoronin; Belongs to the WD repeat coronin family. (484 aa)
Ptk2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1027 aa)
Foxo4Forkhead box protein O4. (506 aa)
Ccl5C-C motif chemokine. (91 aa)
I79_019878Sortilin. (1038 aa)
I79_020258Dedicator of cytokinesis protein 4; Belongs to the DOCK family. (1853 aa)
Nox4NADPH oxidase 4. (130 aa)
Abhd2Abhydrolase domain-containing protein 2. (425 aa)
PostnPeriostin isoform 6. (785 aa)
H671_2g5523Rap guanine nucleotide exchange factor 3-like protein. (979 aa)
Arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
I79_022301Calcium/calmodulin-dependent protein kinase type II delta chain. (225 aa)
I79_022305Proprotein convertase subtilisin/kexin type 5. (170 aa)
Iqgap1Ras GTPase-activating-like protein IQGAP1. (1675 aa)
P2ry6p2Y purinoceptor 6. (328 aa)
I79_023125Proprotein convertase subtilisin/kexin type 5. (661 aa)
I79_023816Proprotein convertase subtilisin/kexin type 5. (306 aa)
I79_023937Sortilin-related receptor. (88 aa)
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
I79_024593Uncharacterized protein. (194 aa)
I79_024807Protein FAM19A5. (87 aa)
Pak1Serine/threonine-protein kinase PAK 1. (325 aa)
P2ry2p2Y purinoceptor 2; Belongs to the G-protein coupled receptor 1 family. (151 aa)
I79_025170Slit-like 2 protein. (345 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
I79_025549WNT1-inducible-signaling pathway protein 1. (274 aa)
Sorl1Sortilin-related receptor. (223 aa)
Trib1Tribbles-like 1. (286 aa)
MycMyc proto-oncogene protein. (281 aa)
I79_025798Vitronectin. (230 aa)
Has2Hyaluronan synthase 2. (337 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
I79_000300Plexin-A1. (457 aa)
I79_000133Myosin-Va; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1737 aa)
ilkIntegrin-linked protein kinase. (452 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Serpine1Plasminogen activator inhibitor 1; Belongs to the serpin family. (270 aa)
I79_007297Plasminogen activator inhibitor 1; Belongs to the serpin family. (108 aa)
Mef2cMyocyte-specific enhancer factor 2C. (465 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (975 aa)
I79_010073Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (511 aa)
Il6stInterleukin-6 receptor subunit beta. (914 aa)
Ssh1Protein phosphatase Slingshot-like 1. (1001 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa)
I79_011934Semaphorin-6D. (150 aa)
I79_011935Semaphorin-6D; Belongs to the semaphorin family. (780 aa)
Atp7aCopper-transporting ATPase 1. (1457 aa)
Ddr2Discoidin domain-containing receptor 2. (854 aa)
I79_013437Nuclear receptor subfamily 4 group A member 3. (598 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
I79_013660Beta-type platelet-derived growth factor receptor. (454 aa)
PdgfrbBeta-type platelet-derived growth factor receptor. (528 aa)
I79_013999Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (328 aa)
AdipoqAdiponectin. (248 aa)
Lpar1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
Lrp1Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
I79_006679Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
Gna13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
APEDNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
I79_026218Calcium/calmodulin-dependent protein kinase type II delta chain. (64 aa)
I79_025994WNT1-inducible-signaling pathway protein 1. (136 aa)
I79_025944Hyaluronan synthase 2. (151 aa)
I79_006462cGMP-dependent protein kinase 1, beta isozyme; Belongs to the protein kinase superfamily. (227 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
S1pr2Sphingosine 1-phosphate receptor 2. (352 aa)
Igf1Insulin-like growth factor I. (75 aa)
FgaFibrinogen alpha chain. (1209 aa)
I79_005379Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. (158 aa)
Igfbp5Insulin-like growth factor-binding protein 5. (271 aa)
Il18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (196 aa)
Nfe2l2Nuclear factor erythroid 2-related factor 2. (588 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
Dock7Dedicator of cytokinesis protein 7; Belongs to the DOCK family. (540 aa)
SmoSmoothened-like; Belongs to the G-protein coupled receptor Fz/Smo family. (984 aa)
I79_003100Myocardin. (371 aa)
MdkMidkine. (160 aa)
SrcTyrosine-protein kinase. (536 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
I79_002178Urokinase-type plasminogen activator; Belongs to the peptidase S1 family. (397 aa)
Gna12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
Pde4dPhosphodiesterase. (507 aa)
Dock5Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (1446 aa)
I79_001487Progesterone receptor. (741 aa)
I79_001274Rap guanine nucleotide exchange factor 4. (761 aa)
I79_001046Neurofibromin. (2164 aa)
VtnVitronectin. (876 aa)
Plxna1Plexin-A1. (777 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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