(31 nodes) Negative regulation of smooth muscle cell migration network (Cricetulus griseus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Gna13	Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
	Cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
	Serpine1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (270 aa)
	I79_007297	Plasminogen activator inhibitor 1; Belongs to the serpin family. (108 aa)
	Mef2c	Myocyte-specific enhancer factor 2C. (465 aa)
	I79_011934	Semaphorin-6D. (150 aa)
	I79_025170	Slit-like 2 protein. (345 aa)
	I79_011935	Semaphorin-6D; Belongs to the semaphorin family. (780 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Lrp1	Prolow-density lipoprotein receptor-related protein 1. (2217 aa)
	Ppargc1a	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
	Adipoq	Adiponectin. (248 aa)
	Aif1	Allograft inflammatory factor 1. (80 aa)
	Drd4	D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
	I79_024807	Protein FAM19A5. (87 aa)
	I79_024593	Uncharacterized protein. (194 aa)
	Coro1b	Coronin; Belongs to the WD repeat coronin family. (484 aa)
	APE	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (317 aa)
	Trib1	Tribbles-like 1. (286 aa)
	Abhd2	Abhydrolase domain-containing protein 2. (425 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	I79_001046	Neurofibromin. (2164 aa)
	Gna12	Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
	I79_003100	Myocardin. (371 aa)
	Nfe2l2	Nuclear factor erythroid 2-related factor 2. (588 aa)
	Igfbp5	Insulin-like growth factor-binding protein 5. (271 aa)
	I79_005379	Tropomyosin alpha-1 chain; Belongs to the tropomyosin family. (158 aa)
	S1pr2	Sphingosine 1-phosphate receptor 2. (352 aa)
	MED4	Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
	I79_006462	cGMP-dependent protein kinase 1, beta isozyme; Belongs to the protein kinase superfamily. (227 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adipoq	I79_007297	G3HYG0	G3HA55	Adiponectin.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.612
Adipoq	PPARG	G3HYG0	G3HVG0	Adiponectin.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.885
Adipoq	Ppargc1a	G3HYG0	G3HWZ1	Adiponectin.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha.	0.706
Adipoq	Serpine1	G3HYG0	G3HA54	Adiponectin.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.584
Cav1	PPARG	G3H9I8	G3HVG0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.526
Gna12	Gna13	G3GVE4	G3H860	Guanine nucleotide-binding protein subunit alpha-12.	Guanine nucleotide-binding protein subunit alpha-13.	0.986
Gna12	S1pr2	G3GVE4	G3H6D8	Guanine nucleotide-binding protein subunit alpha-12.	Sphingosine 1-phosphate receptor 2.	0.978
Gna13	Gna12	G3H860	G3GVE4	Guanine nucleotide-binding protein subunit alpha-13.	Guanine nucleotide-binding protein subunit alpha-12.	0.986
Gna13	S1pr2	G3H860	G3H6D8	Guanine nucleotide-binding protein subunit alpha-13.	Sphingosine 1-phosphate receptor 2.	0.990
I79_003100	Mef2c	G3GZ48	G3HAW1	Myocardin.	Myocyte-specific enhancer factor 2C.	0.564
I79_006462	MED4	G3H7W7	G3H7W4	cGMP-dependent protein kinase 1, beta isozyme; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.868
I79_007297	Adipoq	G3HA55	G3HYG0	Plasminogen activator inhibitor 1; Belongs to the serpin family.	Adiponectin.	0.612
I79_007297	Lrp1	G3HA55	G3HW34	Plasminogen activator inhibitor 1; Belongs to the serpin family.	Prolow-density lipoprotein receptor-related protein 1.	0.439
I79_007297	PPARG	G3HA55	G3HVG0	Plasminogen activator inhibitor 1; Belongs to the serpin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.476
I79_011934	I79_011935	G3HMH1	G3HMH2	Semaphorin-6D.	Semaphorin-6D; Belongs to the semaphorin family.	0.915
I79_011935	I79_011934	G3HMH2	G3HMH1	Semaphorin-6D; Belongs to the semaphorin family.	Semaphorin-6D.	0.915
I79_024593	I79_025170	G3IL32	G3IMN0	Uncharacterized protein.	Slit-like 2 protein.	0.894
I79_025170	I79_024593	G3IMN0	G3IL32	Slit-like 2 protein.	Uncharacterized protein.	0.894
Lrp1	I79_007297	G3HW34	G3HA55	Prolow-density lipoprotein receptor-related protein 1.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.439
Lrp1	Serpine1	G3HW34	G3HA54	Prolow-density lipoprotein receptor-related protein 1.	Plasminogen activator inhibitor 1; Belongs to the serpin family.	0.439