STRINGSTRING
I79_024415 I79_024415 Patl1 Patl1 Eif3e Eif3e I79_001756 I79_001756 I79_001733 I79_001733 Top3a Top3a Sp3 Sp3 I79_000932 I79_000932 I79_000761 I79_000761 Rnf111 Rnf111 Casp8ap2 Casp8ap2 Nfe2 Nfe2 I79_022868 I79_022868 Blm Blm I79_022532 I79_022532 Mtor Mtor Isg20 Isg20 I79_021076 I79_021076 I79_020166 I79_020166 Rere Rere Trim8 Trim8 Daxx Daxx I79_018974 I79_018974 Lrch4 Lrch4 Wdfy3 Wdfy3 CgPICR_012539 CgPICR_012539 I79_018592 I79_018592 I79_018586 I79_018586 Rfwd3 Rfwd3 I79_017872 I79_017872 I79_017450 I79_017450 Zbtb16 Zbtb16 Ski Ski Rnf4 Rnf4 Rad51 Rad51 N4bp1 N4bp1 Ppargc1a Ppargc1a I79_015395 I79_015395 I79_015356 I79_015356 Cdk9 Cdk9 Mre11 Mre11 Dapk3 Dapk3 Rb1 Rb1 Topors Topors I79_013082 I79_013082 I79_012926 I79_012926 I79_012607 I79_012607 Sqstm1 Sqstm1 Magt1 Magt1 Shkbp1 Shkbp1 I79_011258 I79_011258 I79_010700 I79_010700 Mlip Mlip Tp53inp1 Tp53inp1 I79_010245 I79_010245 Smc6 Smc6 Kat6a Kat6a Hipk2 Hipk2 I79_009832 I79_009832 I79_009767 I79_009767 Pml Pml Trim16 Trim16 Max Max I79_008145 I79_008145 Chek2 Chek2 Ube2i Ube2i Nr2c1 Nr2c1 Ikbke Ikbke I79_007550 I79_007550 Tp53inp2 Tp53inp2 I79_007385 I79_007385 Pias2 Pias2 Sirt1 Sirt1 Zmym2 Zmym2 I79_004964 I79_004964 Rpa2 Rpa2 Thap1 Thap1 Rgs14 Rgs14 H671_3g8832 H671_3g8832 I79_003898 I79_003898 Hoga1 Hoga1 Topbp1 Topbp1 Hipk3 Hipk3 I79_003024 I79_003024 Rpain Rpain Tp53 Tp53 Chd3 Chd3 I79_002131 I79_002131 Rnf6 Rnf6 I79_001964 I79_001964 Usp7 Usp7 Cbx5 Cbx5 I79_026101 I79_026101 Tert Tert Smc5 Smc5 Rpa1 Rpa1 I79_025454 I79_025454 CgPICR_012325 CgPICR_012325 I79_023244 I79_023244
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I79_024415Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (755 aa)
Patl1Protein PAT1-like 1. (695 aa)
Eif3eEukaryotic translation initiation factor 3 subunit E. (84 aa)
I79_001756Tripartite motif-containing protein 16. (197 aa)
I79_001733Mitogen-activated protein kinase. (1186 aa)
Top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1004 aa)
Sp3Transcription factor Sp3. (338 aa)
I79_000932Small ubiquitin-related modifier 2. (52 aa)
I79_000761Non-specific serine/threonine protein kinase; Belongs to the PI3/PI4-kinase family. (1026 aa)
Rnf111E3 ubiquitin-protein ligase Arkadia. (990 aa)
Casp8ap2CASP8-associated protein 2. (1413 aa)
Nfe2Transcription factor NF-E2 45 kDa subunit. (374 aa)
I79_022868G/T mismatch-specific thymine DNA glycosylase. (212 aa)
BlmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (464 aa)
I79_022532Structural maintenance of chromosomes protein 5. (861 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
Isg20Interferon-stimulated gene 20 kDa protein. (174 aa)
I79_021076Calcium-binding and coiled-coil domain-containing protein 2. (104 aa)
I79_020166Arginine-glutamic acid dipeptide repeats protein. (1473 aa)
RereArginine-glutamic acid dipeptide repeats protein. (173 aa)
Trim8Tripartite motif-containing protein 8. (551 aa)
DaxxDeath domain-associated protein 6. (708 aa)
I79_018974Leucine-rich repeat and calponin-likey domain-containing protein 4. (253 aa)
Lrch4Leucine-rich repeat and calponin-likey domain-containing protein 4. (423 aa)
Wdfy3WD repeat and FYVE domain-containing protein 3. (1924 aa)
CgPICR_012539Small ubiquitin-related modifier. (112 aa)
I79_018592Calcium-binding and coiled-coil domain-containing protein 2. (151 aa)
I79_018586Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN. (345 aa)
Rfwd3RING finger and WD repeat domain-containing protein 3. (641 aa)
I79_017872RING finger and WD repeat domain-containing protein 3. (105 aa)
I79_017450Zinc finger and BTB domain-containing protein 16. (236 aa)
Zbtb16Zinc finger and BTB domain-containing protein 16. (423 aa)
SkiSki oncogene. (636 aa)
Rnf4RING finger protein 4. (128 aa)
Rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
N4bp1NEDD4-binding protein 1. (811 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
I79_015395Replication protein A 30 kDa subunit. (333 aa)
I79_015356Heat shock factor protein 1. (524 aa)
Cdk9Cell division protein kinase 9; Belongs to the protein kinase superfamily. (372 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (705 aa)
Dapk3Death-associated protein kinase 3. (530 aa)
Rb1Retinoblastoma-associated protein. (302 aa)
ToporsE3 ubiquitin-protein ligase Topors. (964 aa)
I79_013082Homeodomain-interacting protein kinase 1. (1249 aa)
I79_012926Death domain-associated protein 6. (393 aa)
I79_012607Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (568 aa)
Sqstm1Sequestosome-1. (358 aa)
Magt1Transcriptional regulator ATRX. (2344 aa)
Shkbp1SH3KBP1-binding protein 1. (1696 aa)
I79_011258Sentrin-specific protease 2. (314 aa)
I79_010700Transcription factor Sp3. (441 aa)
MlipUncharacterized protein C6orf142. (202 aa)
Tp53inp1Tumor protein p53-inducible nuclear protein 1. (239 aa)
I79_010245Structural maintenance of chromosomes protein 6. (141 aa)
Smc6Structural maintenance of chromosomes protein 6. (54 aa)
Kat6aHistone acetyltransferase MYST3. (200 aa)
Hipk2Homeodomain-interacting protein kinase 2. (1189 aa)
I79_009832G/T mismatch-specific thymine DNA glycosylase. (327 aa)
I79_009767Structural maintenance of chromosomes protein 6. (818 aa)
PmlPutative transcription factor PML. (540 aa)
Trim16Tripartite motif-containing protein 16. (274 aa)
MaxProtein max. (87 aa)
I79_008145Zinc finger protein 605. (769 aa)
Chek2Serine/threonine-protein kinase Chk2. (539 aa)
Ube2iSUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
Nr2c1Nuclear receptor subfamily 2 group C member 1. (590 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon. (640 aa)
I79_007550Eukaryotic translation initiation factor 3 subunit E; Belongs to the eIF-3 subunit E family. (263 aa)
Tp53inp2Tumor protein p53-inducible nuclear protein 2. (222 aa)
I79_007385E3 SUMO-protein ligase PIAS2. (116 aa)
Pias2E3 SUMO-protein ligase PIAS2. (157 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
Zmym2Zinc finger MYM-type protein 2. (1352 aa)
I79_004964ETS-related transcription factor Elf-4. (716 aa)
Rpa2Replication protein A 32 kDa subunit. (248 aa)
Thap1THAP domain-containing protein 1. (94 aa)
Rgs14Regulator of G-protein signaling 14. (817 aa)
H671_3g8832E3 ubiquitin-protein ligase. (169 aa)
I79_003898RING finger protein 6. (477 aa)
Hoga1Dihydrodipicolinate synthase-like, mitochondrial. (804 aa)
Topbp1DNA topoisomerase II-binding protein 1. (1517 aa)
Hipk3Homeodomain-interacting protein kinase 3. (513 aa)
I79_003024Homeodomain-interacting protein kinase 3; Belongs to the protein kinase superfamily. (366 aa)
RpainRPA-interacting protein. (187 aa)
Tp53Cellular tumor antigen p53. (148 aa)
Chd3Chromodomain-helicase-DNA-binding protein 3. (126 aa)
I79_002131MHC class II transactivator. (1168 aa)
Rnf6E3 ubiquitin-protein ligase. (666 aa)
I79_001964Teneurin-2. (107 aa)
Usp7Ubiquitin carboxyl-terminal hydrolase 7. (82 aa)
Cbx5Heterochromatin protein 1 alpha. (191 aa)
I79_026101E3 SUMO-protein ligase NSE2. (68 aa)
TertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (138 aa)
Smc5Structural maintenance of chromosomes protein 5. (80 aa)
Rpa1Replication protein A 70 kDa DNA-binding subunit. (209 aa)
I79_025454Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (182 aa)
CgPICR_012325Small ubiquitin-related modifier. (95 aa)
I79_023244Bloom syndrome protein-like. (721 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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