STRINGSTRING
Ptgs2 Ptgs2 Pla2g4a Pla2g4a I79_001744 I79_001744 Ncor1 Ncor1 Pdk1 Pdk1 Ppara Ppara ELOVL5 ELOVL5 Abcd2 Abcd2 I79_001236 I79_001236 SIRT4 SIRT4 I79_025689 I79_025689 I79_018654 I79_018654 Fabp5 Fabp5 Erfe Erfe Pla2g3 Pla2g3 Dbi Dbi Insig2 Insig2 I79_005488 I79_005488 I79_005015 I79_005015 Rgn Rgn Akt1 Akt1 Fabp3 Fabp3 Erlin2 Erlin2 Ppargc1a Ppargc1a Gk Gk I79_000677 I79_000677 I79_010352 I79_010352 I79_010620 I79_010620 I79_010839 I79_010839 Fabp1 Fabp1 I79_010883 I79_010883 Nr1h3 Nr1h3 I79_016547 I79_016547 I79_016201 I79_016201 Pdk2 Pdk2 Trex1 Trex1 Scap Scap I79_015806 I79_015806 Adipoq Adipoq Wdtc1 Wdtc1 Mid1ip1 Mid1ip1 Mlycd Mlycd Nfe2l1 Nfe2l1 Ghsr Ghsr Acadvl Acadvl I79_010155 I79_010155 C1qtnf2 C1qtnf2 Cyp7a1 Cyp7a1 I79_008173 I79_008173 I79_022786 I79_022786 Irs2 Irs2 Cav1 Cav1 Avpr1a Avpr1a I79_007247 I79_007247 Ankrd30a Ankrd30a Brca1 Brca1 Mfsd2a Mfsd2a Akt2 Akt2 Mapk9 Mapk9 Apoc2 Apoc2 Etfbkmt Etfbkmt I79_012733 I79_012733 Fmo4 Fmo4 Fmo2 Fmo2 Sirt1 Sirt1 EIF6 EIF6 I79_000973 I79_000973 Prkag2 Prkag2 Pdk3 Pdk3 I79_013437 I79_013437 I79_013531 I79_013531 Ppard Ppard Cd74 Cd74 I79_013971 I79_013971 I79_014045 I79_014045 I79_014111 I79_014111 Pdk4 Pdk4 CgPICR_002342 CgPICR_002342 Dgat2 Dgat2 PPARG PPARG I79_024997 I79_024997 Cpt1a Cpt1a Dgat1 Dgat1 Anxa1 Anxa1 Lpgat1 Lpgat1 Nr1h2 Nr1h2 Hnf4a Hnf4a IL1B IL1B Apoc3 Apoc3 CgPICR_005982 CgPICR_005982 Apoa5 Apoa5 Trib3 Trib3 I79_020433 I79_020433 H671_3g10030 H671_3g10030 Irs1 Irs1 Mtor Mtor I79_022367 I79_022367 I79_022390 I79_022390 Agt Agt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Pla2g4aPhospholipase A2. (749 aa)
I79_001744Nuclear receptor corepressor 1. (680 aa)
Ncor1Nuclear receptor corepressor 1. (1591 aa)
Pdk1Protein-serine/threonine kinase. (344 aa)
PparaPeroxisome proliferator-activated receptor alpha. (393 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
Abcd2ATP-binding cassette sub-family D member 2. (741 aa)
I79_001236Bile salt export pump. (1096 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (255 aa)
I79_025689Epididymal-specific lipocalin-13; Belongs to the calycin superfamily. Lipocalin family. (158 aa)
I79_018654Carnitine O-palmitoyltransferase 1, liver isoform. (467 aa)
Fabp5Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (101 aa)
ErfeProtein FAM132B. (344 aa)
Pla2g3Group 3 secretory phospholipase A2. (398 aa)
DbiAcyl-CoA-binding protein. (119 aa)
Insig2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
I79_005488Progesterone-induced-blocking factor 1. (757 aa)
I79_005015Pantothenate kinase 2, mitochondrial. (251 aa)
RgnRegucalcin. (265 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Fabp3Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (121 aa)
Erlin2Erlin-2. (339 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
GkGlycerol kinase. (273 aa)
I79_000677Cannabinoid receptor 1; Belongs to the G-protein coupled receptor 1 family. (415 aa)
I79_010352Acetyl-CoA carboxylase 2. (2287 aa)
I79_010620Alpha-synuclein; Belongs to the synuclein family. (166 aa)
I79_010839Eukaryotic translation initiation factor 2-alpha kinase 3. (783 aa)
Fabp1Fatty acid-binding protein, liver. (149 aa)
I79_010883Gastric inhibitory polypeptide. (205 aa)
Nr1h3Oxysterols receptor LXR-alpha. (402 aa)
I79_016547DCC-interacting protein 13-beta. (634 aa)
I79_016201Peroxisomal Lon protease-like 2. (758 aa)
Pdk2Protein-serine/threonine kinase. (407 aa)
Trex1Three prime repair exonuclease 1. (320 aa)
ScapSterol regulatory element-binding protein cleavage-activating protein. (1276 aa)
I79_015806Acyl-CoA-binding protein. (87 aa)
AdipoqAdiponectin. (248 aa)
Wdtc1WD and tetratricopeptide repeats protein 1. (675 aa)
Mid1ip1Mid1-interacting protein 1. (183 aa)
MlycdMalonyl-CoA decarboxylase, mitochondrial. (190 aa)
Nfe2l1Nuclear factor erythroid 2-related factor 1. (740 aa)
GhsrGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
AcadvlVery long-chain specific acyl-CoA dehydrogenase, mitochondrial. (652 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
C1qtnf2Complement C1q tumor necrosis factor-related protein 2. (285 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (360 aa)
I79_008173Perilipin; Belongs to the perilipin family. (419 aa)
I79_022786Ankyrin repeat domain-containing protein 26. (249 aa)
Irs2Insulin receptor substrate 2. (465 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
I79_007247Williams-Beuren syndrome chromosomal region 14 protein-like. (709 aa)
Ankrd30aAnkyrin repeat domain-containing protein 26. (1699 aa)
Brca1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1790 aa)
Mfsd2aMajor facilitator superfamily domain-containing protein 2. (527 aa)
Akt2Non-specific serine/threonine protein kinase. (200 aa)
Mapk9Mitogen-activated protein kinase 9. (303 aa)
Apoc2Apolipoprotein C-II. (100 aa)
EtfbkmtUPF0516 protein C12orf72-like. (126 aa)
I79_012733Flavin-containing monooxygenase. (88 aa)
Fmo4Flavin-containing monooxygenase. (367 aa)
Fmo2Flavin-containing monooxygenase. (129 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
I79_000973Transcription factor SOX-10. (360 aa)
Prkag25'-AMP-activated protein kinase subunit gamma-2. (305 aa)
Pdk3Protein-serine/threonine kinase. (415 aa)
I79_013437Nuclear receptor subfamily 4 group A member 3. (598 aa)
I79_013531Ankyrin repeat domain-containing protein 26. (390 aa)
PpardPeroxisome proliferator-activated receptor delta. (440 aa)
Cd74H-2 class II histocompatibility antigen gamma chain. (329 aa)
I79_013971ATP-binding cassette sub-family D member 1. (694 aa)
I79_014045Ankyrin repeat domain-containing protein 26. (102 aa)
I79_014111Protein-serine/threonine kinase. (60 aa)
Pdk4Protein-serine/threonine kinase. (178 aa)
CgPICR_002342Acyl-CoA-binding protein. (87 aa)
Dgat2Diacylglycerol O-acyltransferase 2. (388 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
I79_024997Ankyrin repeat domain-containing protein 26. (238 aa)
Cpt1aCarnitine O-palmitoyltransferase 1, liver isoform. (127 aa)
Dgat1Diacylglycerol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family. (327 aa)
Anxa1Annexin. (346 aa)
Lpgat1Acyl-CoA:lysophosphatidylglycerol acyltransferase 1. (351 aa)
Nr1h2Oxysterols receptor LXR-beta. (445 aa)
Hnf4aHepatocyte nuclear factor 4-alpha. (464 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (237 aa)
Apoc3Apolipoprotein C-III. (76 aa)
CgPICR_005982Apolipoprotein A-IV. (230 aa)
Apoa5Apolipoprotein A-V. (363 aa)
Trib3Tribbles-like 3. (353 aa)
I79_020433Carcinoembryonic antigen-related cell adhesion molecule 1. (155 aa)
H671_3g10030Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (204 aa)
Irs1Insulin receptor substrate 1. (1233 aa)
MtorSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2520 aa)
I79_022367Nucleobindin-2. (420 aa)
I79_022390Peroxisome proliferator-activated receptor alpha. (110 aa)
AgtAngiotensinogen; Belongs to the serpin family. (477 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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