STRINGSTRING
FSHB FSHB LDLR LDLR I79_025745 I79_025745 Nfkb1 Nfkb1 I79_025482 I79_025482 Kit Kit Armc5 Armc5 Asah1 Asah1 Lep Lep Acadvl Acadvl Abca2 Abca2 H671_3g8566 H671_3g8566 Rora Rora I79_021840 I79_021840 H671_3g10030 H671_3g10030 I79_021093 I79_021093 Ddx20 Ddx20 I79_021004 I79_021004 Rest Rest I79_019630 I79_019630 I79_019629 I79_019629 I79_019626 I79_019626 I79_019625 I79_019625 Apoa5 Apoa5 CgPICR_005982 CgPICR_005982 Apoa1 Apoa1 H6pd H6pd Sf1 Sf1 Nr1d1 Nr1d1 I79_018763 I79_018763 I79_018762 I79_018762 I79_018761 I79_018761 I79_018655 I79_018655 Fgf19 Fgf19 Clcn2 Clcn2 Serpina12 Serpina12 I79_017093 I79_017093 Hrh1 Hrh1 I79_002195 I79_002195 Kcnma1 Kcnma1 Scp2 Scp2 Ttc39a Ttc39a I79_001429 I79_001429 Gnb3 Gnb3 I79_001236 I79_001236 I79_000120 I79_000120 H671_1g2878 H671_1g2878 Dkkl1 Dkkl1 Tnf Tnf I79_015952 I79_015952 I79_015916 I79_015916 Foxa2 Foxa2 Tspo Tspo Nr0b1 Nr0b1 Ppargc1a Ppargc1a Dkk3 Dkk3 I79_015207 I79_015207 I79_015046 I79_015046 Dgat2 Dgat2 I79_013993 I79_013993 Pex2 Pex2 Snai2 Snai2 Dhcr7 Dhcr7 Apoe Apoe Fmo5 Fmo5 I79_012333 I79_012333 I79_011712 I79_011712 I79_011711 I79_011711 Abcg1 Abcg1 Scap Scap Igf1r Igf1r Cga Cga Wnt4 Wnt4 I79_010458 I79_010458 I79_010155 I79_010155 I79_009834 I79_009834 Egr1 Egr1 Snai1 Snai1 Fgf1 Fgf1 Nr3c1 Nr3c1 Dgkq Dgkq I79_008906 I79_008906 Bmp6 Bmp6 Cyp7a1 Cyp7a1 H671_2g5853 H671_2g5853 I79_007989 I79_007989 I79_007908 I79_007908 Lmf1 Lmf1 Stub1 Stub1 I79_007399 I79_007399 Sirt1 Sirt1 I79_007261 I79_007261 Atp1a1 Atp1a1 Igf1 Igf1 LHCGR LHCGR Insig2 Insig2 I79_005015 I79_005015 I79_004628 I79_004628 Star Star Erlin2 Erlin2 Thrb Thrb I79_003906 I79_003906 Apob Apob I79_003342 I79_003342 I79_000024 I79_000024 Prox1 Prox1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FSHBFollicle stimulating hormone beta-subunit protein. (129 aa)
LDLRLow-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family. (862 aa)
I79_025745Nuclear receptor subfamily 1 group D member 1. (226 aa)
Nfkb1Nuclear factor NF-kappa-B p105 subunit. (509 aa)
I79_025482Nuclear factor NF-kappa-B p105 subunit. (144 aa)
KitMast/stem cell growth factor receptor. (452 aa)
Armc5Armadillo repeat-containing protein 5. (926 aa)
Asah1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
AcadvlVery long-chain specific acyl-CoA dehydrogenase, mitochondrial. (652 aa)
Abca2ATP-binding cassette sub-family A member 2. (457 aa)
H671_3g8566Ragulator complex protein LAMTOR1-like protein. (236 aa)
RoraNuclear receptor ROR-alpha. (959 aa)
I79_021840Nuclear receptor ROR-gamma. (341 aa)
H671_3g10030Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (204 aa)
I79_021093Sterol regulatory element-binding protein 2. (2034 aa)
Ddx20Putative ATP-dependent RNA helicase DDX20. (484 aa)
I79_021004Putative ATP-dependent RNA helicase DDX20. (190 aa)
RestRE1-silencing transcription factor. (1047 aa)
I79_019630Liver carboxylesterase 1; Belongs to the type-B carboxylesterase/lipase family. (765 aa)
I79_019629Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (564 aa)
I79_019626Liver carboxylesterase 4. (105 aa)
I79_019625Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (514 aa)
Apoa5Apolipoprotein A-V. (363 aa)
CgPICR_005982Apolipoprotein A-IV. (230 aa)
Apoa1Apolipoprotein A-I. (264 aa)
H6pdGDH/6PGL endoplasmic bifunctional protein. (789 aa)
Sf1Splicing factor 1. (522 aa)
Nr1d1Nuclear receptor subfamily 1 group D member 1. (508 aa)
I79_018763Liver carboxylesterase 4. (393 aa)
I79_018762Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (370 aa)
I79_018761Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (448 aa)
I79_018655Galanin. (198 aa)
Fgf19Fibroblast growth factor 15; Belongs to the heparin-binding growth factors family. (115 aa)
Clcn2Chloride channel protein 2. (333 aa)
Serpina12Serpin A12; Belongs to the serpin family. (414 aa)
I79_017093SEC14-like protein 4. (356 aa)
Hrh1Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (489 aa)
I79_002195Calcium-activated potassium channel subunit alpha-1. (326 aa)
Kcnma1Uncharacterized protein. (462 aa)
Scp2Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
Ttc39aTetratricopeptide repeat protein 39A. (577 aa)
I79_001429Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (500 aa)
Gnb3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (227 aa)
I79_001236Bile salt export pump. (1096 aa)
I79_000120Bone morphogenetic protein 5. (260 aa)
H671_1g2878SEC14-like protein 3. (419 aa)
Dkkl1Dickkopf-like protein 1. (230 aa)
TnfTumor necrosis factor; Belongs to the tumor necrosis factor family. (234 aa)
I79_015952SEC14-like protein 5. (712 aa)
I79_015916Insulin-like growth factor II. (155 aa)
Foxa2Hepatocyte nuclear factor 3-beta. (430 aa)
TspoTranslocator protein. (169 aa)
Nr0b1Nuclear receptor subfamily 0 group B member 1. (470 aa)
Ppargc1aPeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (894 aa)
Dkk3Dickkopf-related protein 3. (348 aa)
I79_01520725-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (232 aa)
I79_015046Low-density lipoprotein receptor. (160 aa)
Dgat2Diacylglycerol O-acyltransferase 2. (388 aa)
I79_013993Tetratricopeptide repeat protein 39B. (658 aa)
Pex2Peroxisome assembly factor 1. (334 aa)
Snai2Zinc finger protein SNAI2-like protein. (268 aa)
Dhcr77-dehydrocholesterol reductase. (471 aa)
ApoeApolipoprotein E. (313 aa)
Fmo5Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
I79_012333Epoxide hydrolase 2. (464 aa)
I79_011712Signal transducer and activator of transcription. (793 aa)
I79_011711Signal transducer and activator of transcription 5B. (274 aa)
Abcg1ATP-binding cassette sub-family G member 1. (647 aa)
ScapSterol regulatory element-binding protein cleavage-activating protein. (1276 aa)
Igf1rInsulin-like growth factor 1 receptor. (191 aa)
CgaGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (160 aa)
Wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (288 aa)
I79_010458Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (451 aa)
I79_010155Sterol regulatory element-binding protein 1. (1050 aa)
I79_009834Disabled-like 2. (705 aa)
Egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
Snai1Zinc finger protein SNAI1-like protein. (264 aa)
Fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Nr3c1Glucocorticoid receptor. (748 aa)
DgkqDiacylglycerol kinase. (491 aa)
I79_008906Zinc finger protein Gfi-1. (333 aa)
Bmp6Bone morphogenetic protein 6. (296 aa)
Cyp7a1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (360 aa)
H671_2g5853Tetratricopeptide repeat protein 39B. (402 aa)
I79_007989Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (375 aa)
I79_007908Lipase maturation factor 1. (168 aa)
Lmf1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (355 aa)
Stub1STIP1-likey and U box-containing protein 1. (231 aa)
I79_007399MAM and LDL-receptor class A domain-containing protein C10orf112. (1182 aa)
Sirt1NAD-dependent deacetylase sirtuin-1. (554 aa)
I79_007261NADPH--cytochrome P450 reductase. (522 aa)
Atp1a1Sodium/potassium-transporting ATPase subunit alpha. (773 aa)
Igf1Insulin-like growth factor I. (75 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (688 aa)
Insig2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
I79_005015Pantothenate kinase 2, mitochondrial. (251 aa)
I79_004628Phosphodiesterase. (786 aa)
StarSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (279 aa)
Erlin2Erlin-2. (339 aa)
ThrbThyroid hormone receptor beta. (377 aa)
I79_003906Fibroblast growth factor receptor 4. (1040 aa)
ApobApolipoprotein B-100. (3537 aa)
I79_003342Apolipoprotein B-100. (946 aa)
I79_000024Aldo-keto reductase family 1 member C18. (219 aa)
Prox1Prospero homeobox protein 1. (738 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
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