STRINGSTRING
Gja1 Gja1 ICAM1 ICAM1 Ptgs2 Ptgs2 Asic2 Asic2 I79_001070 I79_001070 Nos1 Nos1 Kcna5 Kcna5 I79_001488 I79_001488 Dock5 Dock5 I79_002035 I79_002035 Trpm4 Trpm4 I79_002251 I79_002251 Hrh1 Hrh1 Uts2r Uts2r Faah Faah Bmpr2 Bmpr2 Lep Lep Adra2b Adra2b Edn1 Edn1 Tacr1 Tacr1 Mmp2 Mmp2 Oxtr Oxtr Hrh2 Hrh2 Drd1 Drd1 Gja5 Gja5 F2r F2r Akt1 Akt1 Adra1d Adra1d Fga Fga Fgb Fgb I79_006005 I79_006005 CgPICR_019210 CgPICR_019210 I79_006450 I79_006450 Atp1a2 Atp1a2 I79_006562 I79_006562 Cav1 Cav1 Avpr1a Avpr1a I79_007478 I79_007478 Shc1 Shc1 Zdhhc21 Zdhhc21 I79_008250 I79_008250 I79_008579 I79_008579 Adra1b Adra1b I79_008941 I79_008941 I79_009728 I79_009728 Cx3cl1 Cx3cl1 Atp2b1 Atp2b1 I79_011367 I79_011367 Adra1a Adra1a I79_013454 I79_013454 I79_013721 I79_013721 Smtnl2 Smtnl2 Tbxa2r Tbxa2r Avpr2 Avpr2 Ahr Ahr Chga Chga Adm Adm Hif1a Hif1a Edn3 Edn3 I79_016797 I79_016797 Htr2c Htr2c Agtr1 Agtr1 Htr1a Htr1a Per2 Per2 Chrm3 Chrm3 I79_018131 I79_018131 Htr2a Htr2a Npy1r Npy1r Adra2a Adra2a I79_020009 I79_020009 I79_020258 I79_020258 Ptgs1 Ptgs1 Dusp5 Dusp5 Alox5 Alox5 I79_022685 I79_022685 I79_025174 I79_025174 Map2k1 Map2k1 Dbh Dbh
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gja1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
ICAM1Intercellular adhesion molecule 1. (527 aa)
Ptgs2Prostaglandin G/H synthase 2. (604 aa)
Asic2Amiloride-sensitive cation channel 1, neuronal; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (219 aa)
I79_001070Amiloride-sensitive cation channel 1, neuronal; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (104 aa)
Nos1Nitric oxide synthase; Produces nitric oxide (NO). (1413 aa)
Kcna5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (603 aa)
I79_001488Rho GTPase-activating protein 10-like. (439 aa)
Dock5Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (1446 aa)
I79_002035Alpha-2C adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (230 aa)
Trpm4Transient receptor potential cation channel subfamily M member 4. (315 aa)
I79_002251Type-1 angiotensin II receptor. (117 aa)
Hrh1Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (489 aa)
Uts2rUrotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
FaahFatty-acid amide hydrolase 1. (579 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LepLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Adra2bAlpha-2B adrenergic receptor. (449 aa)
Edn1Endothelin-1. (202 aa)
Tacr1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
Mmp272 kDa type IV collagenase. (662 aa)
OxtrOxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (353 aa)
Hrh2Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (358 aa)
Drd1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (448 aa)
Gja5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
F2rProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (396 aa)
Akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Adra1dAlpha-1D adrenergic receptor. (485 aa)
FgaFibrinogen alpha chain. (1209 aa)
FgbFibrinogen beta chain. (407 aa)
I79_006005Melatonin receptor type 1B; Belongs to the G-protein coupled receptor 1 family. (240 aa)
CgPICR_019210Melatonin receptor type 1B. (112 aa)
I79_006450Monoglyceride lipase. (328 aa)
Atp1a2Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1194 aa)
I79_006562Voltage-dependent L-type calcium channel subunit alpha-1C. (1112 aa)
Cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (147 aa)
Avpr1aVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (423 aa)
I79_007478Alpha-1-syntrophin. (344 aa)
Shc1SHC-transforming protein 1. (579 aa)
Zdhhc21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
I79_008250Endothelin-2. (137 aa)
I79_008579WD repeat-containing protein 35. (1083 aa)
Adra1bAlpha-1B adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (291 aa)
I79_008941Receptor protein-tyrosine kinase. (962 aa)
I79_009728Thromboxane-A synthase; Belongs to the cytochrome P450 family. (453 aa)
Cx3cl1Fractalkine. (335 aa)
Atp2b1Plasma membrane calcium-transporting ATPase 1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (384 aa)
I79_011367Plasma membrane calcium-transporting ATPase 1. (327 aa)
Adra1aAlpha-1A adrenergic receptor. (465 aa)
I79_013454Smoothelin-like protein 1. (461 aa)
I79_013721P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (360 aa)
Smtnl2Smoothelin-like protein 2. (139 aa)
Tbxa2rThromboxane A2 receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
Avpr2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. (298 aa)
AhrAryl hydrocarbon receptor. (247 aa)
ChgaChromogranin-A. (434 aa)
AdmProcalcitonin/adrenomedullin containing protein. (184 aa)
Hif1aHypoxia-inducible factor 1 alpha. (820 aa)
Edn3Endothelin-3. (274 aa)
I79_016797Dual specificity mitogen-activated protein kinase kinase 1. (129 aa)
Htr2c5-hydroxytryptamine receptor 2C. (317 aa)
Agtr1Type-1A angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Htr1a5-hydroxytryptamine receptor 1A. (422 aa)
Per2Period circadian protein-like 2. (1262 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (589 aa)
I79_0181315-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (237 aa)
Htr2a5-hydroxytryptamine receptor 2A. (264 aa)
Npy1rNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
Adra2aAlpha-2A adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (418 aa)
I79_020009Phosphodiesterase. (597 aa)
I79_020258Dedicator of cytokinesis protein 4; Belongs to the DOCK family. (1853 aa)
Ptgs1Prostaglandin G/H synthase 1. (589 aa)
Dusp5Dual specificity protein phosphatase 5. (110 aa)
Alox5Arachidonate 5-lipoxygenase. (674 aa)
I79_022685Dopamine beta-hydroxylase. (534 aa)
I79_025174Gamma-adducin. (560 aa)
Map2k1Dual specificity mitogen-activated protein kinase kinase 1. (101 aa)
DbhDopamine beta-hydroxylase. (117 aa)
Your Current Organism:
Cricetulus griseus
NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.