(78 nodes) Fatty acid oxidation network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CgPICR_016246	Leukotriene-B(4) omega-hydroxylase 2; Belongs to the cytochrome P450 family. (522 aa)
	Acad10	Acyl-CoA dehydrogenase family member 10. (1069 aa)
	Sesn2	Sestrin-2. (480 aa)
	I79_003501	Very long-chain acyl-CoA synthetase. (491 aa)
	Mlycd	Malonyl-CoA decarboxylase, mitochondrial. (190 aa)
	Hao1	Hydroxyacid oxidase 1. (373 aa)
	Cpt2	Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
	Eci2	Peroxisomal 3,2-trans-enoyl-CoA isomerase. (358 aa)
	Pex5	Peroxisomal targeting signal 1 receptor. (640 aa)
	Phyh	Phytanoyl-CoA dioxygenase, peroxisomal. (338 aa)
	Lep	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	Acad11	Acyl-CoA dehydrogenase family member 11. (779 aa)
	Acoxl	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (597 aa)
	Hadh	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (116 aa)
	Bdh2	3-hydroxybutyrate dehydrogenase type 2. (83 aa)
	Cpt1a	Carnitine O-palmitoyltransferase 1, liver isoform. (127 aa)
	Adh5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (326 aa)
	I79_025013	Carnitine O-palmitoyltransferase 1, muscle isoform. (265 aa)
	Cpt1b	Carnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (417 aa)
	Adh7	Alcohol dehydrogenase class 4 mu/sigma chain. (362 aa)
	Crat	Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
	I79_024352	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (271 aa)
	I79_023932	ATP-binding cassette sub-family D member 3. (572 aa)
	Abcd4	ATP-binding cassette sub-family D member 4. (113 aa)
	I79_023401	Cytochrome P450 4V3. (209 aa)
	I79_023215	Carnitine O-palmitoyltransferase 1, brain isoform. (165 aa)
	Cpt1c	Carnitine O-palmitoyltransferase 1, brain isoform. (212 aa)
	Slc25a17	Peroxisomal membrane protein PMP34; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	Abcd2	ATP-binding cassette sub-family D member 2. (741 aa)
	Echdc1	Enoyl-CoA hydratase domain-containing protein 1; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	Etfb	Electron transfer flavoprotein subunit beta. (255 aa)
	I79_021396	Isovaleryl-CoA dehydrogenase, mitochondrial. (422 aa)
	Pex13	Peroxisomal membrane protein PEX13. (376 aa)
	Acadsb	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial. (389 aa)
	I79_018654	Carnitine O-palmitoyltransferase 1, liver isoform. (467 aa)
	Acox2	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (668 aa)
	I79_017834	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial. (273 aa)
	Acadm	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (96 aa)
	I79_001918	Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa)
	Scp2	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
	Acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
	Hadha	Trifunctional enzyme subunit alpha, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	Hadhb	Trifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (367 aa)
	Acadvl	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial. (652 aa)
	Alox12	Arachidonate 12-lipoxygenase, 12S-type. (553 aa)
	Eci1	3,2-trans-enoyl-CoA isomerase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (243 aa)
	Acat1	Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa)
	Mapk14	Mitogen-activated protein kinase. (349 aa)
	I79_016549	10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. (855 aa)
	Adipoq	Adiponectin. (248 aa)
	Auh	Methylglutaconyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (230 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (402 aa)
	Acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (556 aa)
	I79_013971	ATP-binding cassette sub-family D member 1. (694 aa)
	CgPICR_013006	Transmembrane protein HSPC323-like. (122 aa)
	Ppard	Peroxisome proliferator-activated receptor delta. (440 aa)
	Crot	Peroxisomal carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (335 aa)
	Pex2	Peroxisome assembly factor 1. (334 aa)
	I79_013210	3-ketoacyl-CoA thiolase B, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. (372 aa)
	I79_013205	3-ketoacyl-CoA thiolase B, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. (279 aa)
	I79_012608	2,4-dienoyl-CoA reductase, mitochondrial. (215 aa)
	Ilvbl	Acetolactate synthase-like protein; Belongs to the TPP enzyme family. (632 aa)
	I79_011644	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial. (177 aa)
	I79_011643	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (246 aa)
	Ehhadh	Peroxisomal bifunctional enzyme. (701 aa)
	Ech1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial. (97 aa)
	Acads	Short-chain specific acyl-CoA dehydrogenase, mitochondrial. (412 aa)
	I79_010243	Peroxisomal multifunctional enzyme type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (461 aa)
	Prkaa1	Non-specific serine/threonine protein kinase. (477 aa)
	I79_009783	Acetyl-CoA acetyltransferase, cytosolic. (88 aa)
	CgPICR_011488	Acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	Gcdh	Glutaryl-CoA dehydrogenase, mitochondrial. (430 aa)
	I79_007261	NADPH--cytochrome P450 reductase. (522 aa)
	I79_006775	Complement C1q tumor necrosis factor-related protein 9. (125 aa)
	I79_006440	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (380 aa)
	Hsd17b10	3-hydroxyacyl-CoA dehydrogenase type-2-like protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	I79_005339	Alcohol dehydrogenase class-3. (160 aa)
	Adipor1	Adiponectin receptor protein 1. (375 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Abcd2	Abcd4	G3IFZ6	G3IHZ5	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 4.	0.962
Abcd2	Ech1	G3IFZ6	G3HJB5	ATP-binding cassette sub-family D member 2.	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial.	0.472
Abcd2	Eci2	G3IFZ6	G3GZ21	ATP-binding cassette sub-family D member 2.	Peroxisomal 3,2-trans-enoyl-CoA isomerase.	0.594
Abcd2	I79_003501	G3IFZ6	G3H053	ATP-binding cassette sub-family D member 2.	Very long-chain acyl-CoA synthetase.	0.478
Abcd2	I79_010243	G3IFZ6	G3HHY2	ATP-binding cassette sub-family D member 2.	Peroxisomal multifunctional enzyme type 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.629
Abcd2	I79_013971	G3IFZ6	G3HSX2	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 1.	0.712
Abcd2	I79_023932	G3IFZ6	G3IJ99	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 3.	0.766
Abcd2	Pex13	G3IFZ6	G3I8D7	ATP-binding cassette sub-family D member 2.	Peroxisomal membrane protein PEX13.	0.767
Abcd2	Pex2	G3IFZ6	G3HQY9	ATP-binding cassette sub-family D member 2.	Peroxisome assembly factor 1.	0.610
Abcd2	Scp2	G3IFZ6	G3GW11	ATP-binding cassette sub-family D member 2.	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.695
Abcd2	Slc25a17	G3IFZ6	G3IGY2	ATP-binding cassette sub-family D member 2.	Peroxisomal membrane protein PMP34; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.677
Abcd4	Abcd2	G3IHZ5	G3IFZ6	ATP-binding cassette sub-family D member 4.	ATP-binding cassette sub-family D member 2.	0.962
Abcd4	Acox2	G3IHZ5	G3I4W0	ATP-binding cassette sub-family D member 4.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.483
Abcd4	Crat	G3IHZ5	G3IL47	ATP-binding cassette sub-family D member 4.	Carnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family.	0.453
Abcd4	Eci2	G3IHZ5	G3GZ21	ATP-binding cassette sub-family D member 4.	Peroxisomal 3,2-trans-enoyl-CoA isomerase.	0.465
Abcd4	Hao1	G3IHZ5	G3GSC1	ATP-binding cassette sub-family D member 4.	Hydroxyacid oxidase 1.	0.448
Abcd4	I79_013210	G3IHZ5	G3HQV4	ATP-binding cassette sub-family D member 4.	3-ketoacyl-CoA thiolase B, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family.	0.506
Abcd4	I79_013971	G3IHZ5	G3HSX2	ATP-binding cassette sub-family D member 4.	ATP-binding cassette sub-family D member 1.	0.706
Abcd4	Pex13	G3IHZ5	G3I8D7	ATP-binding cassette sub-family D member 4.	Peroxisomal membrane protein PEX13.	0.715
Abcd4	Pex2	G3IHZ5	G3HQY9	ATP-binding cassette sub-family D member 4.	Peroxisome assembly factor 1.	0.545