(92 nodes) Nerve development network (Cricetulus griseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (258 aa)
	Hoxb1	Homeobox protein Hox-B1. (297 aa)
	Hoxb2	Homeobox protein Hox-B2. (407 aa)
	I79_005672	Homeobox protein Hox-B3. (174 aa)
	Sall1	Sal-like protein 1. (1294 aa)
	I79_005534	Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1145 aa)
	Unc13a	Protein unc-13-like A. (1871 aa)
	Isl1	Insulin gene enhancer protein ISL-1. (257 aa)
	Tifab	TRAF-interacting protein with FHA domain-containing protein B. (191 aa)
	Neurog1	Neurogenin-1. (241 aa)
	Hes3	Transcription factor HES-3. (201 aa)
	I79_024097	Vascular cell adhesion protein 1. (225 aa)
	Testin-2	Testin-2; Belongs to the peptidase C1 family. (401 aa)
	I79_022161	Dystrophin. (655 aa)
	Six1	Homeobox protein SIX1. (284 aa)
	I79_022007	Homeobox protein SIX4. (673 aa)
	Vcam1	Vascular cell adhesion protein 1. (220 aa)
	I79_021577	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (248 aa)
	I79_021503	Paired mesoderm homeobox protein 2A. (139 aa)
	I79_021155	Paired box protein Pax-2. (503 aa)
	I79_021038	Plexin-A3. (334 aa)
	Plxna3	Plexin-A3. (656 aa)
	I79_021019	60S ribosomal protein L24. (203 aa)
	I79_020248	Gamma-aminobutyric acid receptor subunit beta-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (231 aa)
	Mnx1	Motor neuron and pancreas homeobox protein 1. (226 aa)
	Slc25a46	Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (289 aa)
	Kcna2	Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (434 aa)
	Col25a1	Collagen alpha-1(XXV) chain. (100 aa)
	I79_018218	Plexin-A4. (498 aa)
	Tcirg1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (835 aa)
	I79_018008	Cyclic nucleotide-gated cation channel beta-1. (897 aa)
	Cngb1	Cyclic nucleotide-gated cation channel beta-1. (141 aa)
	Prkcg	Protein kinase C gamma type. (730 aa)
	I79_017785	Gamma-aminobutyric acid receptor subunit beta-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (338 aa)
	I79_017780	Extracellular sulfatase Sulf-1. (787 aa)
	I79_017234	Sodium/potassium/calcium exchanger 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1206 aa)
	Dmd	Dystrophin. (617 aa)
	Dicer1	Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1907 aa)
	Nrp1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	I79_015503	Transcription factor HES-1. (92 aa)
	Gli3	Zinc finger protein GLI3. (1582 aa)
	Lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	Mafb	Transcription factor MafB. (317 aa)
	Rpl24	60S ribosomal protein L24. (110 aa)
	Gabra5	Gamma-aminobutyric acid receptor subunit alpha-5; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (465 aa)
	Ikzf4	Receptor protein-tyrosine kinase. (1902 aa)
	Chd7	Chromodomain-helicase-DNA-binding protein 7. (615 aa)
	Edn1	Endothelin-1. (202 aa)
	I79_002364	Neuronal pentraxin-1. (416 aa)
	I79_012815	Chromodomain-helicase-DNA-binding protein 7. (150 aa)
	I79_012814	Chromodomain-helicase-DNA-binding protein 7. (100 aa)
	I79_012231	Plexin-A4. (332 aa)
	Plxna4	Plexin-A4. (1078 aa)
	Sema3a	Semaphorin-3A-like protein; Belongs to the semaphorin family. (758 aa)
	Afg3l2	AFG3-like protein 2; Belongs to the AAA ATPase family. (506 aa)
	Ret	Proto-oncogene tyrosine-protein kinase receptor ret; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1432 aa)
	Fgfr3	Fibroblast growth factor receptor 3. (319 aa)
	Slc1a3	Amino acid transporter. (529 aa)
	Ngfr	Tumor necrosis factor receptor superfamily member 16. (429 aa)
	Ngf	Beta-nerve growth factor; Belongs to the NGF-beta family. (112 aa)
	Ephb2	Ephrin type-B receptor 2. (1018 aa)
	Slitrk6	SLIT and NTRK-like protein 6. (817 aa)
	I79_009585	Tyrosine-protein kinase receptor. (727 aa)
	I79_009364	Transcription factor AP-2 alpha. (411 aa)
	I79_009030	T-box transcription factor TBX1. (293 aa)
	Nav2	Neuron navigator 2. (2028 aa)
	I79_008752	Gamma-aminobutyric acid receptor subunit beta-2. (141 aa)
	I79_008633	Integrin alpha-4; Belongs to the integrin alpha chain family. (441 aa)
	Nrp2	Neuropilin; Belongs to the neuropilin family. (909 aa)
	Hoxa3	Homeobox protein Hox-A3. (286 aa)
	Hoxa1	Homeobox protein Hox-A1. (334 aa)
	Ephb1	Ephrin type-B receptor 1. (737 aa)
	Chrnb2	Neuronal acetylcholine receptor subunit beta-2. (495 aa)
	Rnf165	RING finger protein 165. (280 aa)
	I79_007350	Protein atonal-like 7. (65 aa)
	Ext1	Exostosin-1. (388 aa)
	H671_7g18749	60S ribosomal protein L24-like protein. (121 aa)
	Ednra	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	Ctnnb1	Catenin beta-1. (781 aa)
	Adarb1	Double-stranded RNA-specific editase 1. (701 aa)
	Sulf2	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (875 aa)
	Dag1	Dystroglycan. (893 aa)
	Sema3f	Semaphorin-3F; Belongs to the semaphorin family. (785 aa)
	I79_024202	Sal-like protein 1. (825 aa)
	I79_024203	Sal-like protein 1. (121 aa)
	I79_024341	Paired mesoderm homeobox protein 2B. (182 aa)
	Ackr3	C-X-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	Serpine2	Glia-derived nexin; Belongs to the serpin family. (189 aa)
	I79_025440	Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
	Egr2	Early growth response protein 2. (410 aa)
	ilk	Integrin-linked protein kinase. (452 aa)
	Fbxo45	F-box/SPRY domain-containing protein 1. (51 aa)

Your Current Organism:

Cricetulus griseus

NCBI taxonomy Id: 10029
Other names: C. griseus, CHO cell lines, Chinese hamster, Chinese hamsters, Cricetulus aureus, Cricetulus barabensis griseus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chd7	Ctnnb1	G3HPU6	G3H996	Chromodomain-helicase-DNA-binding protein 7.	Catenin beta-1.	0.521
Chd7	I79_012814	G3HPU6	G3HPU4	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.886
Chd7	I79_012815	G3HPU6	G3HPU5	Chromodomain-helicase-DNA-binding protein 7.	Chromodomain-helicase-DNA-binding protein 7.	0.845
Chrnb2	Unc13a	G3HBZ0	G3H4D1	Neuronal acetylcholine receptor subunit beta-2.	Protein unc-13-like A.	0.761
Ctnnb1	Chd7	G3H996	G3HPU6	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	I79_009585	G3H996	G3HG66	Catenin beta-1.	Tyrosine-protein kinase receptor.	0.468
Ctnnb1	I79_012814	G3H996	G3HPU4	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	I79_012815	G3H996	G3HPU5	Catenin beta-1.	Chromodomain-helicase-DNA-binding protein 7.	0.521
Ctnnb1	Ikzf4	G3H996	G3HRK1	Catenin beta-1.	Receptor protein-tyrosine kinase.	0.407
Ctnnb1	ilk	G3H996	C0SSX9	Catenin beta-1.	Integrin-linked protein kinase.	0.452
Dag1	Dmd	G3H8F4	G3I0T8	Dystroglycan.	Dystrophin.	0.976
Dag1	I79_022161	G3H8F4	G3IEL2	Dystroglycan.	Dystrophin.	0.772
Dmd	Dag1	G3I0T8	G3H8F4	Dystrophin.	Dystroglycan.	0.976
Dmd	I79_022161	G3I0T8	G3IEL2	Dystrophin.	Dystrophin.	0.547
Edn1	Ednra	G3H0G9	G3H9A8	Endothelin-1.	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	0.999
Edn1	I79_021577	G3H0G9	G3ID16	Endothelin-1.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.404
Edn1	Ngf	G3H0G9	G3HJF3	Endothelin-1.	Beta-nerve growth factor; Belongs to the NGF-beta family.	0.400
Edn1	Vcam1	G3H0G9	G3ID63	Endothelin-1.	Vascular cell adhesion protein 1.	0.555
Ednra	Edn1	G3H9A8	G3H0G9	Endothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family.	Endothelin-1.	0.999
Ephb1	Ephb2	G3HD26	G3HIN4	Ephrin type-B receptor 1.	Ephrin type-B receptor 2.	0.920